Curator Dashboard

TRACK-HD is a multi-centermulti-national prospective, observational biomarker study of premanifest and early stage HD with no experimental treatment. Objectives: - determine what combination of measures is the most sensitive for detecting change over the natural course of premanifest and early HD - to validate these as potential outcome measures for use in future therapeutic trials Design: - focused on intensive battery of novel assessments - extensive annual assessments - dynamic and fluid protocol - robust evidence-based measures TRACK-HD is a major new international study of Huntingtons disease. It aims to be the most comprehensive study of premanifest and early HD, and will define the best combination of assessments to be used in clinical trials of disease-modifying treatments in HD. TRACK-HD began in January 2008 and involves 360 subjects at 4 sites internationally. Sponsors: This resource is supported by The UK Medical Research Council (MRC), CHDI Foundation, Inc., The Euro-HD Network, The Wellcome Trust, The Department of Health, The Huntingtons Disease Association, and The Brain Research Trust. Keywords: Biomarker, Experimental, Treatment, Research, Therapeutic, Trail, Hunginton''s, Disease, Health,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Affymetrix Gene Expression Service Lab, AGESL was established by IPMB, IMB and IBS, Academia Sinica and opened for service in June 2004. The lab provides a full service from quality control of customer-provided RNA samples to raw data acquisition, including Affymetrix recommended QC procedures, cDNA synthesis, in vitro transcription, fragmentation, hybridization, washing, staining and scanning. Sponsors: This resource is supported by Affymetrix, Inc. Keywords: Gene, Expression, Service, Laboratory, RNA, Data, Synthesis, cDNA, In vitro, Transcription, Fragmentation, Hybrdization, Washing, Staining, Scanning,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Software tool as Program for Comparative Protein Structure Modelling by Satisfaction of Spatial Restraints. Used for homology or comparative modeling of protein three dimensional structures. User provides alignment of sequence to be modeled with known related structures and MODELLER automatically calculates model containing all non hydrogen atoms.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Programming language for all operating systems that lets users work more quickly and integrate their systems more effectively. Often compared to Tcl, Perl, Ruby, Scheme or Java. Some of its key distinguishing features include very clear and readable syntax, strong introspection capabilities, intuitive object orientation, natural expression of procedural code, full modularity, exception-based error handling, high level dynamic data types, extensive standard libraries and third party modules for virtually every task, extensions and modules easily written in C, C (or Java for Python, or .NET languages for IronPython), and embeddable within applications as a scripting interface.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Antibody supplier.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

Company offering a broad range of instrument systems and diagnostic tests for hospitals, reference labs, blood banks, physician offices and clinics to aid in the diagnosis of a range of serious health issues such as infectious diseases, cancer, and diabetes, as well as monitor other important indicators of health.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

The aim of this resource is to facilitate and promote, even through fund-raising, the scientific research for the treatment of Friederich''s Ataxia. The mission of this portal is to: - To distribute information to the people affected by the disease and to make the general population aware. - Promote, fund and support the diagnosis, research, cure and potential treatments. - Promote the cooperation with other voluntary associations both national and international. Sponsors: This resource is supported by the RUDI Committee. Keywords: Research, Diagnosis, Cure, Treatment, Disease, Scientific, Friederich''s Ataxia,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

The ARCHER project is built upon the prototype software developed by the DART (http://dart.edu.au) and ARROW (http://arrow.edu.au) projects to produce a robust set of software tools. These tools: - may be customised to suit the needs of diverse research areas - automate the collection and management of instrument generated data - enable the repository storage of research data and associated metadata - enable collection and tagging of research data in a collaborative environment, and - provide these capabilities in a secure end-to-end proces. :ARCHER developed a ''production-ready'' software tools, operating in a secure environment, to assist researchers to: - collect, capture and retain large data sets from a range of different sources including scientific instruments - deposit data files and data sets to eResearch storage repositories - populate these eResearch data repositories with associated metadata - permit data set annotation and discussion in a collaborative environment, and - support next-generation methods for research publication, dissemination and access.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

A unique, academic, basic research institute elucidating the key aspects of microbial pathogens and the hosts they infect. Focusing on diseases of importance to Australian Primary Industry, the Centre is developing new veterinary vaccines and identifying novel antimicrobial targets. The ARC Centre of Excellence in Structural and Functional Microbial Genomics has brought together a team of leading Australian researchers in the fields of bacterial genomics, bioinformatics, microbial genetics, biochemistry, cell biology, proteomics, structural biology and vaccine immunology. Sponsors: The Centers based at Monash University, Clayton, Victoria and works in partnership with the veterinary faculties of The University of Sydney and The University of Queensland, the CSIRO through its Division of Livestock Industries, the Victorian Bioinformatics Consortium (VBC), the Victorian Partnership for Advanced Computing (VPAC), The State of Victoria through the Department of Primary Industries, the Australian Genome Research Facility (AGRF) and Pfizer Australia. The Centre commenced operations in 2006 and evolved from the ARC Centre for Structural and Functional Microbial Genomics- an earlier ARC initiative. The Centre is also supported by the Victorian State Government through The Department of Innovation, Industry and Regional Development.

• Resource
• SciCrunch
• 14 years ago - by Anonymous

The Australian Research Council (ARC) Centre of Excellence in Bioinformatics (ACB) is a multi-nodal interdisciplinary Center that uniquely brings together genomic and post-genomic bioinformatics, mathematics, statistics, systems analysis and experimental phenomics to produce a deep understanding of how information in the genome is transformed into structure and function in the mammalian cell. ACB is committed to: - Research excellence providing insights into genome-phenome biology. - An advanced education and training program that fosters excellence, exposes students from diverse disciplines to new perspectives in bioinformatics, and generates human capital. - Improved access to skills, tools and facilities at the interface among genomic and post-genomic biology, molecular cell biology, mathematics, statistics, and computing and information sciences. - Critical mass and a national focus for genome-phenome bioinformatics in Australia. Sponsors: This resource is supported by the following: Institute for Molecular Bioscience Newcastle Bioinformatics Initiative QosCosGrid University of Newcastle Centre for Bioinformatics, Biomarker Discovery and Information-based Medicine Keywords: Research, Bioinformatics, Multi-nodal, Interdisciplinary, Genomic, Mathematics, Statistics, System, Analysis, Experimental, Phenomics, Deep, Structure, Function, Mammalian, Cell, Biology, Education, Training, Program, Molecular, Cell biology, Mathematics, Statistics, Computation, Information, Science, Phenome,

• Resource
• SciCrunch
• 17 years ago - by Anonymous

APBS is a software package for modeling biomolecular solvation through solution of the Poisson-Boltzmann equation (PBE), one of the most popular continuum models for describing electrostatic interactions between molecular solutes in salty, aqueous media. APBS was designed to efficiently evaluate electrostatic properties for such simulations for a wide range of length scales to enable the investigation of molecules with tens to millions of atoms. It also provides implicit solvent models of nonpolar solvation which accurately account for both repulsive and attractive solute-solvent interactions. APBS uses FEtk (the Finite Element ToolKit) to solve the Poisson-Boltzmann equation numerically. FEtk is a portable collection of finite element modeling class libraries written in an object-oriented version of C. It is designed to solve general coupled systems of nonlinear partial differential equations using adaptive finite element methods, inexact Newton methods, and algebraic multilevel methods.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

ARTS are new methods for finding transcription start sites (TSS) of RNA Polymerase II binding genes in genomic DNA sequences. Employing Support Vector Machines with advanced sequence kernels, we achieve drastically higher prediction accuracies than state-of-the-art methods. While ARTS'' predictions are point-wise, resolution has been decreased to 1/50 and 1/500 respectively to reduce traffic. Also note that these scores are real-valued, i.e. no artificial cut-off value has been set. This has the advantage that one may choose the cut-off threshold based on ones own cost function and that the relative promoter activity is visible. Finally, note that non ACGT bases have been randomly substituted, therefore especially long N-sleds may completely screw up results on not yet reliably annotated chromosome parts. Sponsors: This resource is partially supported by the PASCAL Network of Excellence (EU #506778), DFG grants JA 379/13-2 and MU 987/2-1. :Keywords: Transcription, Human, RNA polymerase II, binding, Gene, Genomic, DNA, Sequence, :

• Resource
• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented September 6, 2016. AMBeR's aim is to bring together Australia's unique resources for genetic epidemiology and genomics with high level expertise in bioinformatics and statistical science, conduct advanced methodological research, develop new research capacity and competitiveness in cutting-edge techniques, bring them to bear on important medical research problems, train young Australians in bioinformatics and advanced biostatistics, and transfer this expertise to the medical research community.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

This is an open-source Mouse Exonic Evidence-Based Oligonucleotide Chip (MEEBOChip), and are in the process of building the human counterpart, HEEBOChip. The set of 70mers for MEEBOChip is already available from Illumina, Inc., with synthesis of HEEBOChip 70mers in progress. Both arrays are based on a novel selection of exonic long-oligonucleotides (70-mers) from a genomic annotation of the corresponding complete genome sequences, using a transcriptome-based annotation of exon structure for each genomic locus. Using a combination of existing and custom-tailored tools and datasets (including millions of mRNA and EST sequences), we built and performed a systematic examination of transcript-supported exon structure for each genomic locus at the base-pair level (i.e., exonic evidence). This strategy allowed them to select both constitutive and in many cases alternative exons for nearly every gene in the corresponding genome (e.g., protocadherin locus), allowing an unprecedented exploration of human and mouse biology. Furthermore, they used experimentally derived data to hone the selection of these 70mers, helping maximize their performance under typical fluorescent labeling and hybridization conditions. Specifically, they applied and refined the ArrayOligoSelector algorithm from Joe DeRisis laboratory to select 70mers, considering not only their uniqueness (i.e., hybridization specificity) within the content of the entire genome, but also to overcome the known biases of labeling and hybridization methods (e.g., 3-biased reverse transcription and in vitro transcription reactions).

• Resource
• SciCrunch
• 17 years ago - by Anonymous

At the Australian Centre for Plant Functional Genomics (ACPFG), scientists are improving wheat and barley''s tolerance to environmental stresses such as drought, heat, salinity and nutrient toxicities. These stresses known as abiotic stresses, are a major cause of yield and quality loss throughout the world and cause significant problems for cereal growers. These scientists are developing the technologies and resources needed to produce new cereal varieties that allow sustainable farming to generate economic, social and environmental benefits to Australia. ACPFG research is helping to ensure Australia maintains its competitive position in cereal production. - Identify the genetic mechanisms that control tolerance to specific stresses and compare these with those controlling broad range tolerance to abiotic stresses - Use genome-wide analyses to define key cellular processes that enable adapted plants to withstand abiotic stress, and to apply that understanding to the genetic improvement of crops such as wheat and barley - Unravel regulatory networks that control plant growth under abiotic stress - Identify ways of manipulating these networks, through existing genetic diversity or through functional genomics technologies, to deliver tangible industry outcomes, namely cereal varieties better tailored to hostile environments

• Resource
• SciCrunch
• 17 years ago - by Anonymous

A clinical study linking childhood maltreatment and later-life health and well-being. As a collaboration between the Centers for Disease Control and Prevention and Kaiser Permanente''s Health Appraisal Clinic in San Diego, Health Maintenance Organization (HMO) members undergoing a comprehensive physical examination provided detailed information about their childhood experience of abuse, neglect, and family dysfunction. Over 17,000 members chose to participate. To date, over 50 scientific articles have been published and over 100 conference and workshop presentations have been made. Future Directions: The ACE study is now in its 10th year and the prospective phase is currently underway. In this ongoing stage of the study, data are being gathered from various sources including outpatient medical records, pharmacy utilization records, and hospital discharge records to track the subsequent health outcomes and health care use of ACE Study participants. In addition, an examination of National Death Index records will be conducted to establish the relationship between ACE and mortality among the ACE Study population. The ACE Study findings suggest that these experiences are major risk factors for the leading causes of illness and death as well as poor quality of life in the United States. Progress in preventing and recovering from the nation''s worst health and social problems is likely to benefit from the understanding that many of these problems arise as a consequence of adverse childhood experiences. :Sponsors: This resource is supported by the Centers for Disease Control and Prevention and the Kaiser Permanente''s Health Appraisal Clinic in San Diego.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Software for Bayesian analysis of CGH microarrays fitting Hidden Markov Chain models.

• Resource
• SciCrunch
• 13 years ago - by Anonymous

Chem Service, Inc. offers the convenience, cost savings and reliability of 1,000 Certified Standards Grade Organic Chemicals at your fingertips with our Organic Mini Stockroom Kit. Whether your lab is big or small, disposal fees are a concern. The Organic Mini-stockroom offers you the ability to have 1000 different chemicals at quantities ranging from 100mg to 10gm; thus, reducing disposal costs. Over 95% of their neat Standards Grade materials have a purity of 98.0% or greater, and have been analyzed by three or more (where feasible) independent methods of analysis. These do not require purity corrections when preparing a solution for use with EPA methods. Their more than 13,000 organic and inorganic standards, and solutions, support EPA Methods, ASTM Methods, State UST Methods, Air monitoring Methods, and International Methods. They offer explosive residue standards, PCB congeners, petroleum hydrocarbon standards for the petrochemical industry, pesticide standards, FAME, and vitamin standards for food analysis. Suited for identification of unknowns, product screening, optimal chemical selection and small scale chemical reactions, the O-1000A Organic Ministockroom Kit was designed for laboratories with broad chemical classification and indentification needs. Chem Service, Inc. is registered by ABS Quality Evaluations, Inc., to the internationally recognized requirements of ISO 9001 for design, development, production, distribution and servicing of organic neat and synthetic reference materials.

• Resource
• SciCrunch
• 17 years ago - by Anonymous

This program is an international Bioinformatics course at KMUTT designed for students who desire focused training in the elements of computer science, biology and biochemistry needed for a successful career in this exciting new discipline. Students in this program will receive comprehensive training in genomics, algorithms for sequence analysis, database design and management, software engineering and programming (including web-based development). Each student will apply their skills to a practical project, where they will design and implement a solution to a real-world problem under the guidance of an experienced mentor in industry or academia. In order to receive a Masters degree, students must demonstrate mastery of the core subject matter (expected to maintain a minimum grade of B in all core courses) and reach a minimum TOEFL test score of 500 (paper) or 173 (computer) or equivalent prior to or on completion of the course. In 24 monhs students gain the knowledge and skills necessary to enter a career with industry or a career in research as a bioinformatics or biocomputing specialist. The program offers fifteen scholarships each year include tuition and fees plus an additional to cover living expenses for 24 months. :Keywords: Bioinformatics, Computer Science, Biology, Biochemistry, Genomics, Algorithms, Sequence, Analysis, Database, Design, Management, Software, Engineering, Programing, Industry, Academia, Master''s, :

• Resource
• SciCrunch
• 17 years ago - by Anonymous

Blog about how leading-edge bio-science and technology is impacting individuals and society. This blog is an outgrowth of David Ewing Duncan''s new book, Experimental Man: What one mans body reveals about youy future, your health, and our toxic world. In the book he reports taking over 250 tests in the realms of genes, environment, brain and body and explore what these tests can tell us about one persons health, past, present, and future.

• Resource
• SciCrunch
• 14 years ago - by Anonymous