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A stereotaxic probabilistic white matter atlas that fuses DTI-based white matter information with an anatomical template (ICBM-152). This atlas is based on probabilistic tensor maps obtained from 81 normal subjects acquired under an initiative of the International Consortium of Brain Mapping (ICBM). The subjects were normal right-handed adults ranging from 18 to 59 years of age. A hand-segmented white matter parcellation map was created from this averaged map. This map can be used for automated white matter parcellation. The precision of the affine-based image normalization and automated parcellation was measured for a group of normal subjects using manually defined anatomical landmarks. The raw diffusion-weighted images (DWIs) were first co-registered to one of the least diffusion-weighted images and corrected for subject motion with 6-mode rigid transformation with Automated Image Registgration (AIR). The average of all DWIs (aDWI) was calculated and used for a DTI-based anatomic image. For anatomical images to drive the normalization process, aDWIs were used. These images were normalized to the template (ICBM-152) using a 12-mode affine or 4th order polynomial non-linear transformation of AIR. The transformation matrix was then applied to the calculated diffusion tensor field. In the white matter parcellation map (WMPM), deep white matter regions were manually segmented into various anatomic structures based on fiber orientation information.

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• SciCrunch
• 17 years ago - by Anonymous

Two-dimensional images of gene expression for 20,000 genes in a coronal slice of the mouse brain at the level of the striatum by using microarrays in combination with voxelation at a resolution of 1 cubic mm gene expression patterns in the brain obtained through voxelation. Voxelation employs high-throughput analysis of spatially registered voxels (cubes) to produce multiple volumetric maps of gene expression analogous to the images reconstructed in biomedical imaging systems.

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• SciCrunch
• 14 years ago - by Anonymous

The long-term goals of my research are to understand the relationship between neuronal structure and function, and to elucidate the factors that affect neuronal morphology and function over the lifespan of the mammal. Currently we are examining 1) the effects of synaptic activity on neuronal development; 2) the effects of estrogen on neuronal morphology and on learning and memory; and, 3) the effects of aging on neuronal structure and function. We have focused our efforts on single neurons in the hippocampal formation, a region that is critical for certain forms of learning and memory in rodents and humans. From the portal, you may click on a cell in your region of interest to see the complete database of cells from that region. You may also explore the Neuron Database: * Comparative Electrotonic Analysis of Three Classes of Rat Hippocampal Neurons. (Raw data available) * Quantitative, three-dimensional analysis of granule cell dendrites in the rat dentate gyrus. * Dendritic Growth and Regression in Rat Dentate Granule Cells During Late Postnatal Development.(Raw data available) * A light and electron microscopic analysis of the mossy fibers of the rat dentate gyrus.

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• SciCrunch
• 15 years ago - by Anonymous

It is an interdisciplinary research group dedicated to tackling the ethical, legal, policy and social implications of frontier technological developments in the neurosciences. Our objective is to align innovations in the brain sciences with societal, cultural and individual human values through high impact research, education and outreach. The Core''s major research projects are focused on high impact, high visibility areas including the use of drugs and devices for neuroenhancement, ethics in neurodegenerative disease and regenerative medicine research, international and cross-cultural challenges in brain research, neuroimaging in the private sector, and the ethics of personalized medicine, among others. Members of the Core also lead initiatives aside from their research projects. Sponsors: This Core is supported by the University of Brititsh Columbia.

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. A hardware and software package with which a scientist could trace the structure of neurons and other neuroscientific features directly from tissue sections or from a stack of their images into a computer. Then it also could edit, merge, filter, display in 3D, and make realistic plots of the structures. The NTS also includes a substantial statistical package that provided many, now standardized, mathematical and statistical summaries that described each neuron and compared one population to another. Additionally, NTS also provided an embryonic electrotonic modeler that simulates and displayes the electrical functioning of a cell. The NTS uses a special purpose graphics display processor called the VDP3 whose output is presented on a very high resolution CRT. During tracing, the VDP3 presents a variable-diameter cursor and other information directly in the microscope and enables tracing at a high spatial resolution and with measurement of process diameters limited only by the microscope''s optics. Control of tracing is done with a 3D joystick that allows easy control of five input variables: X,Y,Z position, cursor diameter, and a numeric tag. Finally, superb 3D interactive displays of completed cells are provided on the VDP3.

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• SciCrunch
• 14 years ago - by Anonymous

The CellML language is an open standard based on the XML markup language. The purpose of CellML is to store and exchange computer-based mathematical models. CellML allows scientists to share models even if they are using different model-building software. It also enables them to reuse components from one model in another, thus accelerating model building. Although CellML was originally intended for the description of biological models; CellML includes information about model structure (how the parts of a model are organizationally related to one another), mathematics (equations describing the underlying processes) and metadata (additional information about the model that allows scientists to search for specific models or model components in a database or other repository). The CellML team is committed to providing freely available tools for creating, editing, and using CellML models. We provide information regarding tools we are developing internally and links to external projects developing tools which utilize the CellML format. Please let us know if you have an open source CellML tool looking for a home on the internet, as we are able to offer limited hosting services on cellml.org.

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• SciCrunch
• 15 years ago - by Anonymous

The Beckman Institute BNMC brings together researchers from many disciplines at Caltech to address problems in the mechanistic modeling of coupled genomic, intercellular and intracellular processes. It represents an attempt to encourage closer interaction and collaboration between groups in Biology, Control and Dynamical Systems, and the Center for Advanced Computing Research. The focus of BNMC is biochemical phenomena occurring within and between cells, in particular the mechanistic modeling of molecular networks of all kinds (e.g., transcriptional, regulatory, metabolic, signal transduction, mechanical, etc.) with and without spatial variation and intercellular communication. BNMC is formed as a coordinated effort aimed at (1) applying existing capabilities to collaboratively solve biological modeling problems that arise in answering scientific questions in Caltech laboratories, (2) exploring a diversity of novel approaches in order to achieve fundamental advances necessary to address the classes of modeling problems biologists want to solve, and (3) organizing projects to better share human experience as well as common infrastructure to avoid duplication and maximize solution interoperability.

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• SciCrunch
• 17 years ago - by Anonymous

An open source framework for systems biology connecting heterogeneous software applications written in diverse programming languages and running on different platforms-to communicate and use each others'' capabilities via a fast binary encoded-message system. It uses a broker-based, distributed, message-passing architecture, supports many languages including Java, C++, Perl & Python, and runs under Linux,OSX & Win32. Many biological modeling and simulation tools are a part of SBW, including JDesigner and Jarnac.

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• SciCrunch
• 17 years ago - by Anonymous

A Python-based environment of open-source software for mathematics, science, and engineering. The core packages of SciPy include: NumPy, a base N-dimensional array package; SciPy Library, a fundamental library for scientific computing; and IPython, an enhanced interactive console.

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• SciCrunch
• 13 years ago - by Anonymous

An algorithm for detecting chimeric sequences.

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• SciCrunch
• 13 years ago - by Anonymous

Founded in 1905, the University of Sheffield is one of the UK''s leading Russell Group universities with an outstanding record in both teaching and research.

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• SciCrunch
• 16 years ago - submitted by Christie Wang

This resource contains to MATLAB code to make and show videos that can be acquired for free. Data for the movies came from a Macaque attention task. Data on this page came from the multiple-object tracking attention task in a Macaque: The monkeys fixated the white dot at the center of the computer monitor, and four striped stimuli appeared. Their eye position was monitored using an IR camera. The red cross shows where the eyes were pointing throughout each trial. The circle shows the location of the receptive field of the neuron under study during the recording. At the beginning of each trial, either one or two of the stimuli were highlighted, indicating to the monkey that they were the targets of attention. The stimuli then moved to new locations and paused, with one stimulus in the receptive field. After a brief pause, they moved to new locations and the fixation point disappeared. The monkey was rewarded with juice if it then looked at the cued targets. Attention Dask Demo (Avi File) contains Matlab code to make and show movies. Publication from this Dataset: * Differential attention-dependent response modulation across cell classes in macaque visual area V4. JF Mitchell, KA Sundberg, JH Reynolds. Neuron, 2007, 55. 131-141. * Supplemental Material, Neuron, 2007, 55. 131-141. :A Subset of data can be downloaded with analysis routines (easiest to download whole set with full subdirectory structure). Additionally, neuron data files can also be downloaded. :* Routines for Fano Factor, Autocorrelation, and Power Spectra (poster above): :o Plots Spike Waveform and Tests if Significant Visual Response: basic_info.m :o Firing Rate and Fano Factor Analysis (Mitchell et. al, 2007): rate_fano_psth.m :* Routines for Spike-LFP Coherence: :o Spike-LFP Coherence with Rate Normalization (attempting Womelsdorf & Fries, Cosyne, 2008): rate_normalized_coherence.m Sponsors: This work was supported by a grant from the National Eye Institute (EY016161, J.F.M. and J.H.R.), a National Institutes of Health Training Fellowship (J.F.M.), and a National Science Foundation Graduate Research Fellowship (K.A.S.).

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• SciCrunch
• 16 years ago - by Anonymous

The PPI view displays H-InvDB human protein-protein interaction (PPI) information. It is constructed by assigning interaction data to H-InvDB proteins which were originally predicted from transcriptional products generated by the H-Invitational project. The PPI view is now providing 32,198 human PPIs comprised of 9,268 H-InvDB proteins. H-Invitational Database (H-InvDB) is an integrated database of human genes and transcripts. By extensive analyses of all human transcripts, we provide curated annotations of human genes and transcripts that include gene structures, alternative splicing isoforms, non-coding functional RNAs, protein functions, functional domains, sub-cellular localizations, metabolic pathways, protein 3D structure, genetic polymorphisms (SNPs, indels and microsatellite repeats) , relation with diseases, gene expression profiling, molecular evolutionary features, protein-protein interactions (PPIs) and gene families/groups. Sponsors: This research is financially supported by the Ministry of Economy, Trade and Industry of Japan (METI), the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) and the Japan Biological Informatics Consortium (JBIC). Also, this work is partly supported by the Research Grant for the RIKEN Genome Exploration Research Project from MEXT to Y.H. and the Grant for the RIKEN Frontier Research System, Functional RNA research program.

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• SciCrunch
• 17 years ago - by Anonymous

OpenWetWare is an effort to promote the sharing of information, know-how, and wisdom among researchers and groups who are working in biology & biological engineering. OWW provides a place for labs, individuals, and groups to organize their own information and collaborate with others easily and efficiently. In the process, the hope is that OWW will not only lead to greater collaboration between member groups, but also provide a useful information portal to our colleagues, and ultimately the rest of the world. OWW''s approaches to achieve their goals: # Lower the technical barriers to sharing and dissemination of knowledge in biological research # Build a community of researchers in biology and biological engineering that values, practices, and innovates the open sharing of information # Integrate OpenWetWare into existing and future reward structures in research

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• SciCrunch
• 17 years ago - by Anonymous

This site contains the NeSys archive on structure and structure-function data about brain map transformations in the cerebellar system of the rat. This archive presents data not illustrated in the original publications, downloadable original data sets, interactive illustration sequences, including 3-D models. The repository is based on 5 original publications. The publications deal with: - organization of projections to the pontine nuclei from three cortical areas: primary and secondary somatosensory areas (SI and SII), and the primary motor cortex (MI) - organization of pontine neurons projecting to somatosensory representations in the posterior cerebellum The data are also included in the FACCS application, a relational database application with embedded analytical tools, available via the The Rodent Brain Workbench (www.rbwb.org). Sponsors: NeSys Research and Database development is supported by The Research Council of Norway, The European Community (grants QLRT-2000-02256 and QLG3-CT 1999-00763), The Norwegian Consortium for High Performance Computing, and The Jahre Foundation.

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• SciCrunch
• 17 years ago - by Anonymous

A nationwide public health clinical trial conducted to determine the effectiveness of different treatments for people with major depression, in both primary and specialty care settings, who have not responded to initial treatment with an antidepressant. This is the largest and longest study ever done to evaluate depression treatment. The study is completed and no longer recruiting participants. Each of the four levels of the study tested a different medication or medication combination. The primary goal of each level was to determine if the treatment used during that level could adequately treat participants����?? major depressive disorder (MDD). Those who did not become symptom-free could proceed to the next level of treatment. The design of the STAR*D study reflects what is done in clinical practice because it allowed study participants to choose certain treatment strategies most acceptable to them and limited the randomization of each participant only to his/her range of acceptable treatment strategies. No prior studies have evaluated the different treatment strategies in broadly defined participant groups treated in diverse care settings. Over a seven-year period, the study enrolled 4,041 outpatients, ages 18-75 years, from 41 clinical sites around the country, which included both specialty care settings and primary medical care settings. Participants represented a broad range of ethnic and socioeconomic groups. All participants were diagnosed with MDD, were already seeking care at one of these sites, and were referred to the trial by their doctors. * STAR*D Study Medications: Citalopram (Celexa), Sertraline (Zoloft), Bupropion SR (Wellbutrin SR), Venlafaxine XR (Effexor XR), Buspirone (BuSpar), Mirtazapine (Remeron), Triiodothyronine (T3) (Cytomel), Nortriptyline (Pamelor, Aventyl), Tranylcypromine (Parnate), Lithium (Eskalith, Lithobid) *STAR*D Talk Therapy:Cognitive Therapy

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• SciCrunch
• 16 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. The Movement Disorder Virtual University is the healthcare professional's source for movement disorder news, resources and educational activities. MDVU is brought to you by WE MOVE, a not-for-profit organization that has been educating and informing the movement disorder community for over a decade. WE MOVE believes that increased knowledge and understanding promote timely, accurate diagnosis and up-to-date treatment, resulting in a better quality of life for individuals affected by movement disorders. Educational Programs and Resources for Professionals WE MOVE's mission is to facilitate the communication of emerging clinical advances and therapeutic approaches to the management and treatment of movement disorders. Through its award-winning, HON-compliant Web site and as an accredited provider of continuing medical education (CME), WE MOVE strives to meet the educational needs of providers. WE MOVE develops up-to-date training programs and comprehensive, interactive teaching materials to assist professionals in deepening their understanding of neurologic movement disorders, their pathophysiology, etiology, differential diagnosis and state-of-the-art interventions. Case-based Learning (CBL) WE MOVE Case-based Learning (CBL) modules provide an environment that allows for participative learning a well-recognized tool to facilitate the adult learning experience. This self-paced, private learning environment encourages physicians to employ a problem-solving approach, walking step-by-step through the case history, family history, and symptomatology of the patient featured in the case. WE MOVE CBL modules illustrate the diagnostic process and varied approaches to treatment utilized by the thought leader who submitted the case, an invaluable experience for physicians looking to expand their expertise in the diagnosis and treatment of movement disorders. The depth of the WE MOVE CBL learning technology allows each case to highlight treatment of certain aspects of the condition or the efficacy of a given treatment regimen at different stages of disorder progression further enriching the physician's learning experience. For therapies requiring specific expertise in administration (e.g., injectable therapies), video footage of the therapeutic procedure itself enhances the depth of the experience. Co-location of WE MOVE CBL modules within the MDVU creates an unrivaled learning environment for physician education. WE MOVE CBL modules are available at no charge to physicians, 24 hours a day, seven days a week.

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• SciCrunch
• 17 years ago - by Anonymous

The Medical College of Georgia Animal Behavior Center has considerable experience testing the short-term memory and attention capabilities of non-human primates. Testing programs are available to MCG faculty on a collaborative basis, and they are available for contractual agreements with pharmaceutical companies and other external research programs. Delayed-response testing is a well-established means of examining neurochemical, neuroanatomical and therapeutic aspects of ATD, ADHD and schizophrenia. Behavioral paradigms at the Animal Behavior Center are designed around an automated delayed-response task assessing the function of mnemonic and attention processes. Particularly significant is the fact that each paradigm differs regarding the relative emphasis on these two different, yet interdependent, cognitive constructs. The Animal Behavior Center also is experienced in stereotaxic implantation of intracranial electrodes and cannulas in rodents and non-human primates. The basic approaches and procedures of the Animal Behavior Center include: - Delayed Matching-to-Sample (DMTS) - DMTS With a Distractor During the Delay Interval - DMTS With a Titrated Delay Interval

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• SciCrunch
• 17 years ago - by Anonymous

Merger of the Max Planck Institute of Neurobiology and the Max Planck Institute of Ornithology and has been renamed to Circuits - Computation – Models. Department devoted to the study of how the brain computes to understand neural information processing at the level of individual neurons and small neural circuits.

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• SciCrunch
• 17 years ago - by Anonymous

Imaging core offering multiple small animal imaging modalities including MicroSPECT, Optical imaging, MicroCT and Ultrasound have been centralized together with a unit for probe development and a vivarium for the housing of animals in one laboratory.

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• SciCrunch
• 17 years ago - by Anonymous