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DNA software and consultancy: The DNA Alignment software and Network software is used by biologists, anthropologists, medical researchers and students world wide. We carry out phylogeographic consultancy for US, UK and German clients, including legal medical work. We were involved in the tv projects The Real Eve (Discovery Channel) and Motherland (BBC). Our biotechnological director Dr Peter Forster is on the editorial board of the International Journal of Legal Medicine since 1999. Technology and sales consultancy: Clients include multinational corporations, research institutions, and medium to small businesses. Client quotes: Vorbildlicher Einsatz (Dr Stephan Hitzel, EADS, in CADplus 1/2003 journal, Cover Story). We have had an effective business relationship with Fluxus Technology since 1999, and their experience of the German market has proved to be invaluable as part of our operations supplying high end engineering software and consultancy services right across the engineering supply chain (Andy Chinn, Business Development Manager, ITI TranscenData, February 2006). Abstract. Indo-European is the largest and best-documented language family in the world, yet the reconstruction of the Indo-European tree, first proposed in 1863, has remained controversial. Complications may include ascertainment bias when choosing the linguistic data, and disregard for the wave model of 1872 when attempting to reconstruct the tree. Essentially analogous problems were solved in evolutionary genetics by DNA sequencing and phylogenetic network methods, respectively. We now adapt these tools to linguistics, and analyze Indo-European language data, focusing on Celtic and in particular on the ancient Celtic language of Gaul (modern France), by using bilingual GaulishLatin inscriptions. Our phylogenetic network reveals an early split of Celtic within Indo-European. Interestingly, the next branching event separates Gaulish (Continental Celtic) from the British (Insular Celtic) languages, with Insular Celtic subsequently splitting into Brythonic (Welsh, Breton) and Goidelic (Irish and Scottish Gaelic). Taken together, the network thus suggests that the Celtic language arrived in the British Isles as a single wave (and then differentiated locally), rather than in the traditional two-wave scenario (P-Celtic to Britain and Q-Celtic to Ireland). The phylogenetic network furthermore permits the estimation of time in analogy to genetics, and we obtain tentative dates for Indo-European at 8100 BC 1,900 years, and for the arrival of Celtic in Britain at 3200 BC 1,500 years. The phylogenetic method is easily executed by hand and promises to be an informative approach for many problems in historical linguistics.

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• SciCrunch
• 17 years ago - by Anonymous

Flavornet is a compilation of aroma compounds found in human odor space. A seemingly infinite number of perceptions are invoked by less than 1000 odorants that make up this space. These chemicals with mass less than 300 Daltons bind to proteins on the olfactory receptor neurons (ORNs) at the surface of the olfactory epithelium. Excitation of ORNs generates a topographic map of sensory information in the brain that is a representation of the stimulating chemical features of the external world. The Flavornet lists only those odorants that have been found in a human odor space at supra-threshold levels i.e. at levels likely to stimulate ORNs. In Flavornet odorants are arranged by chromatographic and sensory properties. Except for indexing standards the data have been taken from published research using GCO. They are listed by retention indices both Kovats n-paraffin and ethyl ester on four different substrates. A link to a summary page containing chemical properties, sensory descriptors, bibliographies and pdb (protein data bank) files of MM2 minimized structures is provided for each ligand. To be included in Flavornet an odorant must have been detected in a natural product or real environment by some form of quantitative GCO method e.g. dilution analysis (Aroma Extraction Dilution Analysis or CharmAnalysis) perceived intensity analysis (e.g. Osme) or detection frequency analysis (e.g. SNIFF). Therefore, the Flavornet lists only those volatiles that humans use in their chemical ecology. Once on the list, missing data about an odorant was filled in with estimates (shown in square brackets). These estimates will be replaced with experimental measurements as they become available. In every case data from the first report of a GCO detection will be used unless a more accurate report is subsequently made, then, the new data will be included along with the original. The present data was collected from articles published since 1984 using GCO to detect odorants in natural products. In the summers of 2003 and 2004 Hannah E. Collins, Yale University, read over 100 of these articles and checked the chemical data for the odorants against the Chemical Abstract Service databases. Sponsor. Sponsored by DATU Inc.

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• SciCrunch
• 17 years ago - by Anonymous

A graphical viewer of phylogenetic trees and a program for producing publication-ready figures. It is designed to display summarized and annotated trees produced by BEAST.

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• SciCrunch
• 17 years ago - by Anonymous

This document defines the processes and standards that all FLTK developers must follow when developing and documenting FLTK, and how trouble reports are handled and releases are generated. The purpose of defining formal processes and standards is to organize and focus our development efforts, ensure that all developers communicate and develop software with a common vocabulary/style, and make it possible for us to generate and release a high-quality GUI toolkit which can be used with a high degree of confidence. Much of this file describes the existing practices that have been used up through FLTK 1.1.x, however I have also added some new processes/standards to use for future code and releases. The fltk-dev mailing list and fltk.development newsgroup are the primary means of communication between developers. All major design changes must be discussed prior to implementation. Specific Goals The specific goals of the FLTK are as follows: Develop a C++ GUI toolkit based upon sound object-oriented design principles and experience. (*) Minimize CPU usage (fast). (*) Minimize memory usage (light). (*) Support multiple operating systems and windowing environments, including UNIX/Linux, MacOS X, Microsoft Windows, and X11, using the native graphics interfaces. (*) Support OpenGL rendering in environments that provide it. (*) Provide a graphical development environment for designing GUI interfaces, classes, and simple programs. (*) Support UTF-8 text. Support printer rendering in environments that provide it. Support schemes, styles, themes, skinning, etc. to alter the appearance of widgets in the toolkit easily and efficiently. The purpose is to allow applications to tailor their appearance to the underlying OS or based upon personal/user preferences. Support newer C++ language features, such as templating via the Standard Template Library (STL), and certain Standard C++ library interfaces, such as streams. However, FLTK will not depend upon such features and interfaces to minimize portability issues. Support intelligent layout of widgets. Many of these goals are satisfied by FLTK 1.1.x (*), and many complex applications have been written using FLTK on a wide range of platforms and devices. Development of the remaining features is proceding for FLTK 2.0 with a new, namespace-based API. While 2.0 offers some limited 1.x source compatibility, the changes to the underlying widget classes are significant enough to prevent full compatibility. Software Development Practices Documentation All widgets are documented using the Doxygen software; Doxygen comments are placed in the header file for the class comments and any inline methods, while non-inline methods should have their comments placed in the corresponding source file. The purpose of this separation is to place the comments near the implementation to reduce the possibility of the documentation getting out of sync with the code. All widgets must have a corresponding test program which exercises all widget functionality and can be used to generate image(s) for the documentation. Complex widgets must have a written tutorial, either as full text or an outline for later publication The final manuals are formatted using the HTMLDOC software. Sponsor. Easy Software Products

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• SciCrunch
• 17 years ago - by Anonymous

Family members connect with our Family Tree application. We have over 178,385,793 relatives added and growing! Familybuilder, the top family destination on social networks, today announced that it has been chosen by AlwaysOn as one of the AlwaysOn East Top 100 winners. Inclusion in the AlwaysOn East 100 signifies leadership amongst its peers and game-changing approaches and technologies that are likely to disrupt existing markets and entrenched players. Familybuilder was specially selected by the AlwaysOn editorial team and industry experts spanning the globe based on a set of five criteria: innovation, market potential, commercialization, stakeholder value, and media buzz. Familybuilder and the AlwaysOn East Top 100 companies will be honored at AlwaysOn''s Venture Summit East event on June 21st, 2010, at Harvard Business School in Boston, MCA. This two-day executive event features CEO presentations and high-level debates that highlight the significant economic, political, and technology trends impacting the global growth investor on the East Coast. Now more than ever, staying abreast of market conditions and innovations is crucial to financial success. After examining the companies that are on the AOE100 list, it''s obvious that innovation is not only alive and well on the East Coast, it''s accelerating in economic power and scope. says Tony Perkins, founder and editor of AlwaysOn. The companies certainly represent some of the highest-growth opportunities in the private company marketplace. The AlwaysOn East 100 winners were selected from among hundreds of other technology companies nominated by investors, bankers, journalists, and industry insiders. The AlwaysOn editorial team conducted a rigorous three-month selection process to finalize the 2010 list. Familybuilder is the first company to offer applications for communicating and staying in touch with family members on social networks including Facebook, MySpace, and others. The Company, with over 26 million users and over 160 million family members added, is quickly becoming one of the most used family services online. The Company''s flagship application on Facebook, Family Tree, is one of the top 15 non-gaming applications on the platform. With its substantial base of customers, Familybuilder is now expanding into new lines of businesses including a newsletter http://familybuilder.com/newsletter as well as subscription functionality. About AlwaysOn AlwaysOn is the leading business media brand networking the Global Silicon Valley. AlwaysOn helped ignite the social media revolution in early 2003 when it launched the AlwaysOn network. In 2004, it became the first media brand to socially network its online readers and event attendees. AlwaysOn''s preeminent executive event series includes the Summit at Stanford, OnMedia, OnHollywood, Venture Summit Mid-Atlantic, OnDemand, Venture Summit Silicon Valley, Venture Summit East, GoingGreen Silicon Valley, GoingGreen East, and GoingGreen Europe. The AlwaysOn network and live event series continue to lead the industry by empowering its readers, event participants, sponsors, and advertisers like no other media brand.

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• SciCrunch
• 17 years ago - by Anonymous

The database has now been updated to include ALL mutations found in HUS patients, including those in Factor I(FI) and Membrane (MCP). Homology models are available for the domains of FI and MCP and all analysis previously available for Factor H (FH) are now also available for FI and MCP. All SNP records for FH, FI and MCP are also now included in the database on the SNP pages. Only those SNPs within coding regions will be included in the full list of mutations and within the advanced search. For more information on the different versions of the database click here. We have also redesigned the site in order to display information more clearly. Please let us know what you think of the new design. Home Information Mutations Models References Links Submit Contact Us Help Collaborators NEWS !! SEP 2009 The database has now been recovered. Please report any bugs that you notice. NEWS !! MAY 2009 We have suffered from a complete server failure this month but these issues have been sorted out and work is being carried out to restore all the data within our FH-HUS database. Sorry for any inconvenience this may have caused. NEWS !! JAN 2007 Mutations within complement Factor B have also been associated with aHUS. (Goicoechea de Jorge et al., 2007) NEW !! Nov 2006 FH-HUS Database Version 2.1 The database has now been updated to include ALL mutations found in HUS patients, including those in Factor I(FI) and Membrane (MCP). Homology models are available for the domains of FI and MCP and all analysis previously available for Factor H (FH) are now also available for FI and MCP. All SNP records for FH, FI and MCP are also now included in the database on the SNP pages. Only those SNPs within coding regions will be included in the full list of mutations and within the advanced search. For more information on the different versions of the database click here. We have also redesigned the site in order to display information more clearly. Please let us know what you think of the new design. Quick Search Enter Codon No : Choose Protein : Advanced Search Have you or someone you know been diagnosed with aHUS? The information contained on this web site is provided for scientific research purposes only. We do not give medical advice or recommend any particular treatment for specific individuals. Here are several links for patient information on aHUS: http://renux.dmed.ed.ac.uk/ http://en.wikipedia.org/ http://kidney.niddk.nih.gov http://www.webmd.com HUS HUS (Haemolytic Uraemic Syndrome) is a disease associated with microangiopathic haemolytic anemia, thrombocytopenia and acute renal failure. A subgroup of the syndrome is strongly associated with abnormalities within the complement regulator factor H gene. To read information on HUS click here. To read information on Factor H (FH) click here. FH Mutations There are currently 74 Factor H mutations, 10 Factor I mutations and 25 MCP mutations linked with HUS patients within this database. There are also 5 mutations within FH that are associated with MPGN patients. . Following HGVS guidelines, mutations are numbered starting from the ATG initiation codon and include the 18-residue signal peptide. The number of the codon with respect to the mature FH protein and consistent with the RSCB PDB entry for secreted FH (1haq.pdb) is shown alongside in parenthesis. Type I and Type II Phenotype Type I indicates that the mutant protein is either absent from the plasma or present in lower amounts. This indicates the mutation has a structural effect on the mutant protein - ie reducing the stability Type II indicates that the mutant protein is present in normal amounts in plasma. This indicates that the mutation has a functional effect on the protein ie affecting substrate binding References There are three references you can use to reference this database Saunders et al, 2007. The interactive Factor H-atypical hemolytic uremic syndrome mutation database and website: update and integration of membrane cofactor protein and Factor I mutations with structural models. Hum Mutat. 2007 28:222-234. Saunders et al, 2006. An interactive web database of factor H-associated hemolytic uremic syndrome mutations: insights into the structural consequences of disease-associated mutations. Hum Mutat. 2006 27:21-30. Saunders & Perkins, 2006. A user''s guide to the interactive Web database of factor H-associated hemolytic uremic syndrome. Semin Thromb Hemost. 2006 32:160-8. Abstract. BACKGROUND: cblC disease is a cause of hemolytic uremic syndrome (HUS), which has been primarily described in neonates and infants with severe renal and neurological lesions. PATIENTS: Two sisters aged 6 and 8.5 years presented with a latent hemolytic process characterized by undetectable or low plasma haptoglobin, respectively, associated with renal failure and gross proteinuria. Renal biopsies performed in both patients found typical findings of thrombotic microangiopathy suggesting the diagnosis of HUS. Both patients were free of neurologic signs. RESULTS: Biochemical investigations found a cobalamin processing deficiency of the cblC type. Search for additional factors susceptible to worsen endothelial damage revealed homozygosity 677C--> T mutation in the methylenetetrahydrofolate reductase gene as well as heterozygosity for a 3254T--> C mutation in factor H in the patient with the most severe clinical presentation. Long-term subcutaneous administration of hydroxocobalamin in combination with oral betaine and folic acid resulted in clinical and biological improvement in both patients. CONCLUSION: cblC disease may be a cause of chronic HUS with delayed onset in childhood. Superimposed mutation of factor H gene might influence clinical severity.

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• SciCrunch
• 17 years ago - by Anonymous

EyesWeb refers both to the research projects of InfoMus Lab on multimodal interactive systems and expressive gesture, and to the open software platform to support the development of real-time multimodal distributed interactive applications. The EyesWeb project started in 1997, as a natural evolution of the HARP Project (see www.infomus.org). The current release of the open software platform is EyesWeb XMI (eXtended Multimodal Interaction). The EyesWeb software platform has been developed in EU IST projects in the 5th (MEGA, www.megaproject.org) and 6th Framework Programme (TAI-CHI, Tangible Acoustic Interfaces for Computer Human Interaction). EyesWeb has been adopted in several other EU projects, has been licensed to more than 15,000 individual users, companies, and institutions. EyesWeb is also used in University courses and summer schools (e.g. the New York University Summer Program on Music, dance and new technologies). Software tools EyesWeb open software platform FreeFrame SDK Harp Petri Net Visual Editor and Simulation Software (Linux Version) Petri Net Visual Editor and Simulation Software (Win32 Version) Hardware tools Wireless On-Body-Sensors-to-Midi Box Long-distances MIDI tx/rx Video Multiplexer for connecting and synchronizing two videocameras to the same frame grabber Multimedia interfaces for robot-human interaction DanceWeb ultrasound sensor system

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• SciCrunch
• 17 years ago - by Anonymous

Solvers, or optimizers, are software tools that help users find the best way to allocate scarce resources. The resources may be raw materials, machine time or people time, money, or anything else in limited supply. The best or optimal solution may mean maximizing profits, minimizing costs, or achieving the best possible quality. An almost infinite variety of problems can be tackled this way, but here are some typical examples: Finance and Investment Working capital management involves allocating cash to different purposes (accounts receivable, inventory, etc.) across multiple time periods, to maximize interest earnings. Capital budgeting involves allocating funds to projects that initially consume cash but later generate cash, to maximize a firm''s return on capital. Portfolio optimization -- creating efficient portfolios -- involves allocating funds to stocks or bonds to maximize return for a given level of risk, or to minimize risk for a target rate of return. Manufacturing Job shop scheduling involves allocating time for work orders on different types of production equipment, to minimize delivery time or maximize equipment utilization. Blending (of petroleum products, ores, animal feed, etc.) involves allocating and combining raw materials of different types and grades, to meet demand while minimizing costs. Cutting stock (for lumber, paper, etc.) involves allocating space on large sheets or timbers to be cut into smaller pieces, to meet demand while minimizing waste. Distribution and Networks Routing (of goods, natural gas, electricity, digital data, etc.) involves allocating something to different paths through which it can move to various destinations, to minimize costs or maximize throughput. Loading (of trucks, rail cars, etc.) involves allocating space in vehicles to items of different sizes so as to minimize wasted or unused space. Scheduling of everything from workers to vehicles and meeting rooms involves allocating capacity to various tasks in order to meet demand while minimizing overall costs.

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• SciCrunch
• 17 years ago - by Anonymous

Mission The Foundation for Informed Medical Decision Making is a non-profit organization dedicated to assuring that people understand their choices and have the information they need to make sound decisions affecting their health and well being. To accomplish our mission: We promote understanding and adoption of informed medical decision-making. We organize and frame medical evidence in an unbiased manner to help people evaluate their options, particularly in instances where differences in individual preferences and perspectives are likely to affect personal choice. We sponsor research to expand knowledge of how to improve decision quality in health care. Medical Evidence The science of medical care is advancing at a rate that makes the delivery of quality patient-focused care an enormous challenge. New information about disease biology and genetics, rapid development of new tests and treatments, and the shift in disease from largely acute to largely chronic are all important contributing factors. Patient Perspective Medical research on practice variation indicates that patient perspectives are often less important in treatment decisions than factors having little to do with patients or their illnesses, such as geography, economics or supplier-induced demands. The Foundation brings the patient perspective into focus by interviewing real patients who can talk about the choices they made and why. Without the perspective of the patient, we cannot achieve a quality medical decision. Informed Medical Decisions The Foundation believes that it is the convergence of the two concepts: medical evidence and patient perspectives that create a truly informed decision in medical care. Funding The Foundation has worked in a unique partnership with Health Dialog since 1997. Health Dialog delivers patient support services to employers and health plans that are committed to providing excellence to their members or employees. As of July 2006, Health Dialog served seventeen million people through its contracts with healthcare insurers and corporations. Access to the Foundation''s decision support materials is a key benefit that Health Dialog''s clients receive. Health Dialog produces the Foundation''s new programs and distributes decision support materials and services to patients. A portion of Health Dialog''s revenue goes to the Foundation in the form of royalties to support the development of new decision support materials and research on how best to support patient decisions. The Foundation does not accept funding from any source that has a financial interest in any particular approach to medical testing or treatment. Foundation employees and clinical content experts do not accept support from companies that commercially market any kind of treatment or device that might be relevant to a program.

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• SciCrunch
• 17 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE documented on June 4, 2013. Aldente is a tool to identify proteins from peptide mass fingerprinting data. This fast and powerful tool takes advantage of the Hough transform for spectra recalibration and outlier exclusion. The Aldente search form can be used in two modes: for a global view of all the search parameters on one page: click on the section tab All. This global view is useful to have a quick overview before sending the query. to have search parameters grouped into smaller logical sections: click on the corresponding section tab in the tabs banner. Note! Moving from one section to another keeps search parameter selections. For your convenience, you may view / hide the help during your search parameters selection. Use the Help or No help section tab accordingly.

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• SciCrunch
• 17 years ago - by Anonymous

This website is an invitation. an invitation to join scientists and stakeholders in an effort to review the scientific basis of traditional toxicological risk assessment, to provide the toxicological community with the tools it needs to efficiently and transparently judge risks of a diversifying nature and to make toxicology thus fit to meet the challenges of the 21st century. an invitation to participate in the inception and continuous implementation of a new movement in toxicology that aims at adopting an evidence-based approach. an invitation to help bridging the gap between modern toxicological science and risk assessment in order to exploit the wealth of information from new technologies in modern life sciences & toxicological research and to arrive at informed, transparent, judicious and conscientious decisions made on the basis of all evidence available. an invitation to develop a framework that allows combining precious expert insight grown over years of practical experience with structured approaches in basic science, in method assessment and in decision-making. Such evidence-based toxicology might help to make the best possible use of all sources of evidence in an efficient, productive, reliable, acceptable and transparent manner. Why do we need evidence-based toxicology (EBT)? Toxicology and the delivery of effective safety assessment critically relies on concepts and understanding generated by basic scientific research and must therefore adapt constantly to advances in knowledge. However, particularly from the perspective of regulatory toxicology, some of the assessment paradigms and methodologies were established decades ago and have changed little in response to scientific progress. At the same time, changes in our understanding of human disease, changes in the types of product now requiring safety assessment, and changes in the legislative landscape and public expectations pose significant challenges for industry, academia and regulators alike. It is necessary to challenge the status quo and ensure that as a matter of course best scientific practice and technical sophistication is reflected in safety assessment practices such that current and future challenges can be met. It is important therefore to ensure that structures are available that will encourage, facilitate and support a process of critical appraisal and renewal of the toxicological repertoire available for safety assessment. Part of this process is to embrace evidence-based toxicology such that the best possible scientific evidence is applied to judge product safety and likely risks to human health.