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In C. elegans , dhc-1 ( or283 ); mel-28 ( t1684 ) double mutants have a severely reduced brood size compared with each single mutant and compared to the wild type. To determine if this synthetic low-fecundity phenotype is due to reduced potential to produce gametes, we studied gonad length and distal gonad mitotic activity in dhc-1 ( or283 ) mutants, mel-28 ( t1684 ) mutants, wild-type animals, and dhc-1 ( or283 ); mel-28 ( t1684 ) double mutants. Gonad length in dhc-1 ; mel-28 double mutants was the same as the wild type. Using an antibody against phosphorylated histone H3 (PH3), we tracked mitotic activity in mutant and wild-type gonads. We found no significant difference in mitotic activity between the double mutant and the wild-type. These observations suggest that the reduced brood size in dhc-1 ; mel-28 double mutants is not caused by a mitotically-inactive gonad and instead has a different and yet-to-be-determined basis.
Pubmed ID: 39911910
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View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsCenter that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name dhc-1(or283ts) from WB.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name unc-119(ed3) III; ltIs37 IV; ltIs38. from WB.
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The data sets included in this resource are published in Kravitz et al, 2012. Distinct roles for direct and indirect pathway striatal neurons in reinforcement (Nat. Neurosci).
