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Small VCP Interacting Protein (SVIP) is essential for maintaining a unique form of tubular lysosomes (TLs) in Drosophila . Although Caenorhabditis elegans do not have an annotated SVIP ortholog, expression of Drosophila SVIP in the C. elegans intestine induces TLs constitutively, increases autophagic activity, and extends healthspan. Here, we find that expression of the human ortholog of SVIP in the C. elegans gut causes similar physiological and phenotypic effects as Drosophila SVIP , albeit some effects were less pronounced. These results demonstrate that human SVIP can induce functional TLs in C. elegans but may be a weaker allele compared to Drosophila SVIP .
Pubmed ID: 39554807
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Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsNIH is the nations medical research agency - making important medical discoveries that improve health and save lives. The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the primary Federal agency for conducting and supporting medical research. Helping to lead the way toward important medical discoveries that improve peoples health and save lives, NIH scientists investigate ways to prevent disease as well as the causes, treatments, and even cures for common and rare diseases. NIH research impacts: * child and teen health, * men's health, * minority health, * seniors' health, * women's health, and * wellness and lifestyle issues. Composed of 27 Institutes and Centers, the NIH provides leadership and financial support to researchers in every state and throughout the world.
View all literature mentionsMicrosoft system includes integrated digital inverted benchtop microscope for four-color fluorescence, transmitted-light, and color imaging. Provides interchangeable optics with autofocus, single-click multi-channel image acquisition.3.2 Megapixels, monochrome, CMOS camera. Offers software for acquisition, analysis, and automated cell counting.
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The data sets included in this resource are published in Kravitz et al, 2012. Distinct roles for direct and indirect pathway striatal neurons in reinforcement (Nat. Neurosci).
