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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
http://www.wormbase.org/db/get?name=WBStrain00003782
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: crgSi2081 II; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:BCN2081, CGC_BCN2081
Notes: crgSi2081 [rpl-28p::PuroR + myo-2p::GFP + Cbr-unc-119(+)] II. Superficially wild-type. Puromycin resistant. ttTi5605 transposon in EG4322 has been replaced by a single copy insertion crgSi2081. Reference: Semple JI, et al., Nat Methods. 2010 Sep;7(9):725-7.
Proper citation: RRID:WB-STRAIN:WBStrain00003782 Copy
http://www.wormbase.org/db/get?name=WBStrain00003871
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; bqSi711 IV.
Alternate IDs: WB-STRAIN:BN711, CGC_BN711
Notes: bqSi711 [mex-5p::FLP::SL2::mNG + unc-119(+)] IV. Constitutive co-expression of codon-optimised FLP and fluorescent mNeonGreen in the germ line. Reference: Macias-Leon J & Askjaer P. (2018): Efficient FLP-mediated germ-line recombination in C. elegans. Micropublication:biology. Dataset. https:|"Made_by: Javier Macas-Len"
Proper citation: RRID:WB-STRAIN:WBStrain00003871 Copy
http://www.wormbase.org/db/get?name=WBStrain00004055
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: PMID:32550513, PMID:32550493, PMID:33300872, PMID:34505574, PMID:34663906, PMID:34865044, PMID:37507441, PMID:38282418, PMID:38878287
Synonyms: ieSi57 [eft-3p::TIR1::mRuby::unc-54 3'UTR + Cbr-unc-119(+)] II.
Alternate IDs: WB-STRAIN:CA1200, CGC_CA1200
Notes: ieSi57 [eft-3p::TIR1::mRuby::unc-54 3'UTR + Cbr-unc-119(+)] II. Single copy transgene inserted into chromosome II (oxTi179) expressing modified Arabidopsis thaliana TIR1 tagged with mRuby in the soma. This strain can be used for auxin-inducible degradation (AID) in somatic tissues. Reference: Zhang L, et al. Development. 2015 Nov 9. pii: dev.129635.|"WBStrain provided so WBPaper00060223 paper added based on AFP_Strain data."|"WBStrain provided so WBPaper00060754 paper added based on AFP_Strain data."|"WBStrain provided so WBPaper00061869 paper added based on AFP_Strain data."|"WBStrain provided so WBPaper00062146 paper added based on AFP_Strain data."
Proper citation: RRID:WB-STRAIN:WBStrain00004055 Copy
http://www.wormbase.org/db/get?name=WBStrain00004063
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: PMID:37507441
Synonyms: ieSi61 II; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:CA1209, CGC_CA1209
Notes: ieSi61 [ges-1p::TIR1::mRuby::unc-54 3'UTR + Cbr-unc-119(+)] II. Single copy transgene inserted into chromosome II (oxTi179) expressing modified Arabidopsis thaliana TIR1 tagged with mRuby in the intestine. This strain can be used for auxin-inducible degradation (AID) in the intestine. Reference: Zhang L, et al. Development. 2015 Nov 9. pii: dev.129635.
Proper citation: RRID:WB-STRAIN:WBStrain00004063 Copy
http://www.wormbase.org/db/get?name=WBStrain00004073
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: PMID:37708895
Synonyms: ieSi68 II; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:CA1472, CGC_CA1472
Notes: ieSi68 [sun-1p::TIR1::mRuby::htp-1 3'UTR + Cbr-unc-119(+)] II. Single copy transgene inserted into chromosome II (oxTi179) expressing a modified Arabidopsis thaliana TIR1 tagged with mRuby in the germ line and early embryos. This strain can be used for auxin-inducible degradation (AID) in germ line and early embryos. Reference: Zhang L, et al. Development. 2015 Nov 9. pii: dev.129635.|"Supplementary_genotype ieSi68[sun-1p::TIR1::mRuby::htp-1 3'UTR + Cbr-unc-119(+)] II; unc-119(ed3) III"
Proper citation: RRID:WB-STRAIN:WBStrain00004073 Copy
http://www.wormbase.org/db/get?name=WBStrain00004072
Source Database: WormBase (WB)
Affected Genes: WBGene00006311(sun-1)|WBGene00006843(unc-119)
Genomic Alteration: WBGene00006311(sun-1), WBGene00006843(unc-119)
Availability: available
Source References: PMID:37436986
Synonyms: ieSi65 II; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:CA1353, CGC_CA1353
Notes: ieSi65 [sun-1p::TIR1::sun-1 3UTR + Cbr-unc-119(+)] II. Single copy transgene inserted into chromosome II (oxTi179) expressing a modified Arabidopsis thaliana TIR1 in germ line and early embryos. This strain can be used for auxin-inducible degradation (AID) in germ line and early embryos. Reference: Zhang L, et al. Development. 2015 Nov 9. pii: dev.129635.
Proper citation: RRID:WB-STRAIN:WBStrain00004072 Copy
http://www.wormbase.org/db/get?name=WBStrain00004068
Source Database: WormBase (WB)
Affected Genes: WBGene00006377(syp-3)|WBGene00006843(unc-119)
Genomic Alteration: WBGene00006377(syp-3), WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: syp-3(ok758) I; ieSi11 II; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:CA1218, CGC_CA1218
Notes: ieSi11 [syp-3p::EmeraldGFP::syp-3::syp-3 3'UTR + Cbr-unc-119(+)] II. ieSi11 was inserted into ttTi5605 II using MosSCI. Expression of GFP::SYP-3 largely complements syp-3(ok758), but some meiotic nondisjunction is detected above the N2 background (85% embryonic viability; ~1% male self-progeny;). GFP::SYP-3 expression is readily detected in spermatocytes and oocytes in the germline, and localizes to the interface between paired homologous chromosomes during most of meiotic prophase. Reference: Rog O, Dernburg AF. Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00178-3.
Proper citation: RRID:WB-STRAIN:WBStrain00004068 Copy
http://www.wormbase.org/db/get?name=WBStrain00000127
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; niDf199 IV; armEx58.
Alternate IDs: WB-STRAIN:AGK233, CGC_AGK233
Notes: armEx58 [WRM0611aH08-Del8mer + unc-119(+)]. Pick non-Unc to maintain. This strain contains a transgenic array that expresses a derivative WRM0611aH08 fosmid. The WRM0611aH08 fosmid contains the niDF199 locus (around 4 kb) that is deleted in the natural C. elegans isolate strain JU258. JU258 worms lack specific 21U-RNAs normally present in N2 worms due to this deletion of the niDF199 locus. This derivative fosmid construct lacks the upstream 8-mer motif (CTGTTTCA) next to 21U-3372. The expression of this individual 21U-RNA is lost in transgenic animals. unc-119(ed3) was crossed into JU258, the niDf199IV deletion was confirmed by PCR, and these Unc worms were used for bombardment. Reference: Cecere G, et al. Mol Cell. 2012 Sep 14;47(5):734-45.|"Made_by: Cecere & Mansisidore"
Proper citation: RRID:WB-STRAIN:WBStrain00000127 Copy
http://www.wormbase.org/db/get?name=WBStrain00000129
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)|WBGene00006975(zfp-1)
Genomic Alteration: WBGene00006843(unc-119), WBGene00006975(zfp-1)
Availability: available
Source References: EMPTY
Synonyms: zfp-1(ok554) unc-119(ed3) III; armEx14.
Alternate IDs: WB-STRAIN:AGK280, CGC_AGK280
Notes: armEx14 [PHD1-PHD2::FLAG + zfp-1(short isoform) + unc-119(+)]. Pick non-Unc animals to maintain. The fosmid-based armEx14 transgene rescues zfp-1(ok554)/nDf17 lethality. Reference: Avgousti DC, et al. Mol Cell Biol. 2013 Mar;33(5):999-1015.|"Made_by: Cecere & Mansisidore"
Proper citation: RRID:WB-STRAIN:WBStrain00000129 Copy
http://www.wormbase.org/db/get?name=WBStrain00000167
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; bafIs63.
Alternate IDs: WB-STRAIN:ALF63, CGC_ALF63
Notes: bafIs63 [lin-42p(mut)::GFP + unc-119(+)]. lin-42p(mut)::GFP reporter consists of 2 kb upstream of lin-42a isoform subcloned into modified pPD95.75 vector also carrying unc-119(+); all potential DAF-12 binding sites have been mutated. Reference: Hochbaum D, et al. PLoS Genet. 2011 Jul;7(7):e1002179.
Proper citation: RRID:WB-STRAIN:WBStrain00000167 Copy
http://www.wormbase.org/db/get?name=WBStrain00000168
Source Database: WormBase (WB)
Affected Genes: WBGene00000908(daf-12)|WBGene00006843(unc-119)
Genomic Alteration: WBGene00000908(daf-12), WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; daf-12(rh61rh411) X; bafIs62.
Alternate IDs: WB-STRAIN:ALF82, CGC_ALF82
Notes: bafIs62 [lin-42p::GFP + unc-119(+)]. lin-42p::GFP reporter consists of 2 kb upstream of lin-42a isoform subcloned into modified pPD95.75 vector also carrying unc-119(+). Array was crossed into strain ALF3 to create ALF82. Reference: Hochbaum D, et al. PLoS Genet. 2011 Jul;7(7):e1002179.
Proper citation: RRID:WB-STRAIN:WBStrain00000168 Copy
http://www.wormbase.org/db/get?name=WBStrain00000165
Source Database: WormBase (WB)
Affected Genes: WBGene00000908(daf-12)|WBGene00006843(unc-119)
Genomic Alteration: WBGene00000908(daf-12), WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; daf-12(rh61rh411) X; bafIs9.
Alternate IDs: WB-STRAIN:ALF9, CGC_ALF9
Notes: bafIs9 [daf-12::TAP (fosmid) + unc-119(+)]; rescues both daf-12 and unc-119. TAP tag inserted into daf-12 fosmid. Reference: Hochbaum D, et al. PLoS Genet. 2011 Jul;7(7):e1002179.
Proper citation: RRID:WB-STRAIN:WBStrain00000165 Copy
http://www.wormbase.org/db/get?name=WBStrain00000212
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: PMID:37565483
Synonyms: ljSi2 II; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:AQ3236, CGC_AQ3236
Notes: ljSi2 [mec-7::GCaMP6m::SL2::TagRFP + unc-119(+)] II. GCaMP6m (13.693) and RFP expressed in touch receptor neurons (ALML/R, AVM, PVM, PLML/R). Dual expression of GCamp6m and RFP allows for ratio-metric corrections of motion artifacts. Reference: Cho Y, et al. Lab Chip. 2017 Jul 25;17(15):2609-2618.|"Made_by: Dr. William Schafer"
Proper citation: RRID:WB-STRAIN:WBStrain00000212 Copy
http://www.wormbase.org/db/get?name=WBStrain00000239
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: wamSi3 II; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:ARM3, CGC_ARM3
Notes: wamSi3 [eft-3p::mNeptune::unc-54 3'UTR + Cbr-unc-119(+)] II. Expresses a single copy of mNeptune from eft-3 promoter; construct utilizes the unc-54 terminator and 3'UTR. Can be used as a standard for multicolor imaging and quantitative microscopy. Reference: Sands B, et al. 2018. Translational Medicine of Aging Volume 2, January 2018, Pages 110.
Proper citation: RRID:WB-STRAIN:WBStrain00000239 Copy
http://www.wormbase.org/db/get?name=WBStrain00000245
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: wamSi118 II; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:ARM118, CGC_ARM118
Notes: wamSi118 [eft-3p::mCerulean3::unc-54 3'UTR + Cbr-unc-119(+)] II. Expresses a single copy of mCerulean3 from eft-3 promoter; construct utilizes the unc-54 terminator and 3'UTR. Can be used as a standard for multicolor imaging and quantitative microscopy. Reference: Sands B, et al. 2018. Translational Medicine of Aging Volume 2, January 2018, Pages 110.
Proper citation: RRID:WB-STRAIN:WBStrain00000245 Copy
http://www.wormbase.org/db/get?name=WBStrain00000241
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: wamSi7 II; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:ARM7, CGC_ARM7
Notes: wamSi7 [eft-3p::mTagRFP-T::unc-54 3'UTR + Cbr-unc-119(+)] II. Expresses a single copy of mTagRFP-T from eft-3 promoter; construct utilizes the unc-54 terminator and 3'UTR. Can be used as a standard for multicolor imaging and quantitative microscopy. Reference: Sands B, et al. 2018. Translational Medicine of Aging Volume 2, January 2018, Pages 110.
Proper citation: RRID:WB-STRAIN:WBStrain00000241 Copy
http://www.wormbase.org/db/get?name=WBStrain00000242
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: PMID:37857834
Synonyms: wamSi101 V; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:ARM101, CGC_ARM101
Notes: Supplementary_genotype wamSi101 (eft-3p::mTFP::unc-54 3'UTR + Cbr-unc-119 (+)) V unc-119(ed3) III|"wamSi101 [eft-3p::mTFP::unc-54 3'UTR + Cbr-unc-119(+)] V. Expresses a single copy of mTFP from eft-3 promoter; construct utilizes the unc-54 terminator and 3'UTR. Can be used as a standard for multicolor imaging and quantitative microscopy. Reference: Sands B, et al. 2018. Translational Medicine of Aging Volume 2, January 2018, Pages 110."
Proper citation: RRID:WB-STRAIN:WBStrain00000242 Copy
http://www.wormbase.org/db/get?name=WBStrain00000243
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: unc-119(ed3) III; wamSi103 V.
Alternate IDs: WB-STRAIN:ARM103, CGC_ARM103
Notes: wamSi103 [eft-3p::mKO2::unc-54 3'UTR + Cbr-unc-119(+)] V. Expresses a single copy of mKO2 from eft-3 promoter; construct utilizes the unc-54 terminator and 3'UTR. Can be used as a standard for multicolor imaging and quantitative microscopy. Reference: Sands B, et al. 2018. Translational Medicine of Aging Volume 2, January 2018, Pages 110.
Proper citation: RRID:WB-STRAIN:WBStrain00000243 Copy
http://www.wormbase.org/db/get?name=WBStrain00000255
Source Database: WormBase (WB)
Affected Genes: WBGene00003055(lon-1)|WBGene00003918(par-3)|WBGene00006843(unc-119)
Genomic Alteration: WBGene00003055(lon-1), WBGene00003918(par-3), WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: lon-1(e185) par-3(e2074) unc-119(ed3) III; zuIs45 V; sDp3(III;f)
Alternate IDs: WB-STRAIN:ATD3, CGC_ATD3
Notes: Made_by: Lawrence E. Small|"zuIs45 [nmy-2p::nmy-2::GFP + unc-119(+)] V. Pick wild-type to maintain. Worms carrying the sDp3 duplication are wild-type; animals that have lost the duplication are Lon Par (maternal effect lethal). Cross of JJ1473 and KK237. Unknown if unc-119(ed3) is still present or homozygous in background. Reference: Small LE & Dawes AT. Mol Biol Cell. 2017 Aug 1;28(16):2220-2231."
Proper citation: RRID:WB-STRAIN:WBStrain00000255 Copy
http://www.wormbase.org/db/get?name=WBStrain00000270
Source Database: WormBase (WB)
Affected Genes: WBGene00006843(unc-119)
Genomic Alteration: WBGene00006843(unc-119)
Availability: available
Source References: EMPTY
Synonyms: vizSi32 II; unc-119(ed3) III.
Alternate IDs: WB-STRAIN:AUM2071, CGC_AUM2071
Notes: Made_by: Tokyo Furuta|"vizSi32 [cdk-2p(intron)::GFP::tbb-2 3 UTR + unc-119(+)] II. vizSi32 was inserted into ttTi5605 on Chr II using MosSci. Intron 1 of cdk-2 drives drives GFP expression in this transgene. Reference: Furuta T, et al. Development. 2018 May 14;145(10). pii: dev161042. doi: 10.1242/dev.161042."
Proper citation: RRID:WB-STRAIN:WBStrain00000270 Copy
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The data sets included in this resource are published in Kravitz et al, 2012. Distinct roles for direct and indirect pathway striatal neurons in reinforcement (Nat. Neurosci).
