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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Specification URL Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
DEMI
 
Resource Report
Resource Website
1+ mentions
DEMI (RRID:SCR_002291) software resource R package for estimating differential expression from multiple indicators that capitalizes on the high number of concurrent measurements. It extends to various experimental designs and target categories (transcripts, genes, genomic regions) as well as small sample sizes. standalone software, affymetrix, mac os x, unix/linux, windows, r is listed by: OMICtools
has parent organization: CRAN
PMID:24586062 Free, Available for download, Freely available, Acknowledgement requested OMICS_03438 http://cran.r-project.org/web/packages/demi/ SCR_002291 demi: Differential Expression from Multiple Indicators, Differential Expression from Multiple Indicators 2026-09-12 12:55:39 6
flowCore
 
Resource Report
Resource Website
100+ mentions
flowCore (RRID:SCR_002205) software resource A Bioconductor software package for high throughput flow cytometry that provides S4 data structures and basic functions. software package, mac os x, unix/linux, windows, r, cell based assay, flow cytometry, infrastructure is used by: flowBeads
is listed by: OMICtools
has parent organization: Bioconductor
PMID:19358741 Artistic License, v2 OMICS_05596 SCR_002205 flowCore: Basic structures for flow cytometry data 2026-09-12 12:55:38 376
NPTK
 
Resource Report
Resource Website
NPTK (RRID:SCR_002496) NPTK data processing software, image analysis software, registration software, software application, software resource Non-rigid registration / distortion correction tools for enhanced functional localization through the registration of EPI fMRI to high-resolution anatomical MRI. analyze, artifact removal, c++, image-to-image, intermodal, linux, macos, microsoft, magnetic resonance, nifti, nonlinear warp, posix/unix-like, registration, spatial transformation, warping, windows, windows xp, fmri, mri is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC) Free, Available for download, Freely available nlx_155893 SCR_002496 2026-09-12 12:55:41 0
PaleoVu
 
Resource Report
Resource Website
PaleoVu (RRID:SCR_002411) PaleoVu data processing software, data visualization software, software application, software resource A complete browse and visualization tool for all types of paleoclimate and paleoecological data (Version 1.0 for Windows 3.1 and the Macintosh). Point and click to create queries, list site information, display or plot variables and data, or export the data for further processing and analysis. Note: PaleoVu is no longer maintained or supported. Data content is not being updated, and compatibility problems may exist with newer operating systems. PaleoVu is still suitable as a teaching tool, but our internet-based browsing tools are the most up to date source for paleoclimatic data. browse, visualization, paleo, paleoclimatology, ecology, paleoclimate, climate, query, windows, macintosh, paleoecological is listed by: CINERGI
has parent organization: World Data Center for Paleoclimatology
Free SciRes_000130 SCR_002411 2026-09-12 12:55:40 0
flowBeads
 
Resource Report
Resource Website
flowBeads (RRID:SCR_002440) software resource Software package for the analysis of flow cytometry bead data. It extends flowCore to provide functionality specific to bead data. One of the goals of this package is to automate analysis of bead data for the purpose of normalization. software package, mac os x, unix/linux, windows, r, cell based assay, flow cytometry, infrastructure uses: flowCore
is listed by: OMICtools
has parent organization: Bioconductor
Free, Freely available OMICS_05592 SCR_002440 flowBeads: Analysis of flow bead data 2026-09-12 12:55:41 0
flowCyBar
 
Resource Report
Resource Website
1+ mentions
flowCyBar (RRID:SCR_002319) software resource A software package to analyze flow cytometric data using gate information to follow population / community dynamics. software package, mac os x, unix/linux, windows, r, cell based assay, flow cytometry, clustering, visualization is listed by: OMICtools
has parent organization: Bioconductor
GNU General Public License, v2 OMICS_05597 SCR_002319 flowCyBar - Analyze flow cytometric data using gate information 2026-09-12 12:55:39 7
GLIRT
 
Resource Report
Resource Website
GLIRT (RRID:SCR_002390) GLIRT data processing software, image analysis software, registration software, software application, software resource Software for both groupwise registration and longitudinal registration, which are the necessary steps for many brain-related applications. Specifically, groupwise registration is important for unbiased analysis of a large set of MR brain images. Therefore, in this software package, they have included two of their recently-developed groupwise registration algorithms: 1) Improved unbiased groupwise registration guided with the sharp group-mean image, and 2) Hierarchical feature-based groupwise registration with implicit template (Groupwise-HAMMER for short). On the other hand, they also included their recently-developed groupwise longitudinal registration algorithm that aligns not only the longitudinal image sequence for each subject, but also align all longitudinal image sequences of all subjects to the common space simultaneously. analyze, application, c++, image-to-image, intersubject, linux, microsoft, motion analysis, magnetic resonance, posix/unix-like, registration, software, spatial transformation, temporal transformation, win32 (ms windows), windows is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
has parent organization: University of North Carolina at Chapel Hill School of Medicine; North Carolina; USA
Free nlx_155763 http://www.nitrc.org/projects/glirt SCR_002390 Groupwise and Longitudinal Image Registration Toolbox 2026-09-12 12:55:40 0
BRAINSFit
 
Resource Report
Resource Website
10+ mentions
BRAINSFit (RRID:SCR_002340) BRAINSFit data processing software, image analysis software, registration software, software application, software resource A program for registering images with with mutual information based metric. Several registration options are given for 3,6, 9,12,16 parameter (i.e. translate, rigid, scale, scale/skew, full affine) based constraints for the registration. The program uses the Slicer3 execution model framework to define the command line arguments and can be fully integrated with Slicer3 using the module discovery capabilities of Slicer3 affine warp, analyze, c++, console (text based), dicom, image-to-image, intermodal, intersubject, linear warp, macos, microsoft, magnetic resonance, nifti, os independent, posix/unix-like, registration, spatial transformation, warping, windows is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC) BSD License nlx_155701 http://www.nitrc.org/projects/multimodereg SCR_002340 2026-09-12 12:55:39 20
MBASED
 
Resource Report
Resource Website
10+ mentions
MBASED (RRID:SCR_002584) software resource Software package containing functions for allele-specific gene expression (ASE) analysis using meta-analysis based allele-specific expression detection. software package, unix/linux, mac os x, windows, r, gene expression, sequencing, transcription is listed by: OMICtools
has parent organization: Bioconductor
PMID:25315065 Free, Available for download, Freely available OMICS_05502 http://www.bioconductor.org/packages/release/bioc/html/MBASED.html SCR_002584 Meta-analysis Based Allele-Specific Expression Detection, MBASED - Package containing functions for ASE analysis using Meta-analysis Based Allele-Specific Expression Detection 2026-09-12 12:55:43 17
WFU Biological Parametric Mapping Toolbox
 
Resource Report
Resource Website
1+ mentions
WFU Biological Parametric Mapping Toolbox (RRID:SCR_002613) WFU_BPM, WFU BPM data processing software, image analysis software, software application, software resource, software toolkit Software toolbox that performs SPM analysis with voxel-wise imaging covariates. The BPM toolbox incorporates information obtained from other modalities as regressors in a voxel-wise analysis, thereby permitting investigation of more sophisticated hypotheses. The BPM toolbox has been developed in Matlab with a user-friendly interface for performing analyses, including voxel-wise multimodal correlation, ANCOVA, and multiple regression. It has a high degree of integration with the SPM (statistical parametric mapping) software relying on it for visualization and statistical inference. Furthermore, statistical inference for a correlation field, rather than a widely used T-field, has been implemented in the correlation analysis for more accurate results. Requirements: * SPM2 or SPM5 * MATLAB version 6.5 or higher analyze, matlab, microsoft, magnetic resonance, nifti, posix/unix-like, statistical operation, win32 (ms windows), windows is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is related to: SPM
has parent organization: Wake Forest School of Medicine; North Carolina; USA
Human Brain Project ;
NIBIB 1R01EB004673
PMID:17070709 Free, Available for download, Freely available nlx_156016 http://www.nitrc.org/projects/wfu_bpm SCR_002613 BPM - Integrated Tool for Biological Parametric Mapping, WFU Biological Parametric Mapping, BPM toolbox, BPM 2026-09-12 12:55:43 4
Vaa3D
 
Resource Report
Resource Website
100+ mentions
Vaa3D (RRID:SCR_002609) Vaa3D, Vaa3D-Neuron data management software, data processing software, data visualization software, image analysis software, software application, software resource, software toolkit A handy, fast, and versatile 3D/4D/5D Image Visualization & Analysis System for Bioimages & Surface Objects. Vaa3D is a cross-platform (Mac, Linux, and Windows) tool for visualizing large-scale (gigabytes, and 64-bit data) 3D/4D/5D image stacks and various surface data. It is also a container of powerful modules for 3D image analysis (cell segmentation, neuron tracing, brain registration, annotation, quantitative measurement and statistics, etc) and data management. Vaa3D is very easy to be extended via a powerful plugin interface. For example, many ITK tools are being converted to Vaa3D Plugins. Vaa3D-Neuron is built upon Vaa3D to make 3D neuron reconstruction much easier. In a recent Nature Biotechnology paper (2010, 28(4), pp.348-353) about Vaa3D and Vaa3D-Neuron, an order of magnitude of performance improvement (both reconstruction accuracy and speed) was achieved compared to other tools. reusable library, atlas application, c, c++, cygwin, fiber tracking, gnome, image display, kde, linux, macos, microsoft, magnetic resonance, neuronal characterization, development environment, position, posix/unix-like, quantification, registration, rendering, resampling, segmentation, shape analysis, spatial transformation, surface analysis, tractography, visualization, volumetric analysis, warping, win32 (ms windows), windows, windows 95/98/2000, windows nt/2000, windows vista, windows xp, 3d neuron reconstruction, 3d, neuron, reconstruction, microscopy is used by: BICCN
is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is related to: Insight Segmentation and Registration Toolkit
has parent organization: Janelia Research
Howard Hughes Medical Institute PMID:20231818 Free, Available for download, Freely available nlx_156012 http://www.nitrc.org/projects/v3d SCR_002609 V3D, Vaa3D: A Swiss army knife for bioimage visualization & analysis, V3D-Neuron, Vaa3D: A Swiss army knife for bioimage visualization and analysis, 3D Visualization-Assisted Analysis, Vaa3D and Vaa3D-Neuron 2026-09-12 12:55:43 166
TurtleSeg
 
Resource Report
Resource Website
1+ mentions
TurtleSeg (RRID:SCR_002605) TurtleSeg data processing software, image analysis software, segmentation software, software application, software resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 14,2026. An interactive segmentation tool originally designed for 3D medical images. Accurate and automatic 3D medical image segmentation remains an elusive goal and manual intervention is often unavoidable. TurtleSeg implements techniques that allow the user to provide intuitive yet minimal interaction for guiding the 3D segmentation process. analyze, c++, computed tomography, dicom, intensity contour, microsoft, minc, magnetic resonance, nifti, segmentation, win32 (ms windows), windows, windows nt/2000, windows vista, windows xp is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC) THIS RESOURCE IS NO LONGER IN SERVICE nlx_156008 http://www.nitrc.org/projects/turtleseg SCR_002605 TurtleSeg - Interactive 3D Image Segmentation Software 2026-09-12 12:55:43 6
MetaQC
 
Resource Report
Resource Website
10+ mentions
MetaQC (RRID:SCR_006000) software resource Software for quality control and diagnosis for microarray meta-analysis. Quantitative quality control measures include: (1) internal homogeneity of co-expression structure among studies (internal quality control; IQC); (2) external consistency of co-expression structure correlating with pathway database (external quality control; EQC); (3) accuracy of differentially expressed gene detection (accuracy quality control; AQCg) or pathway identification (AQCp); (4) consistency of differential expression ranking in genes (consistency quality control; CQCg) or pathways (CQCp). For each quality control index, the p-values from statistical hypothesis testing are minus log transformed and PCA biplots were applied to assist visualization and decision. Results generate systematic suggestions to exclude problematic studies in microarray meta-analysis and potentially can be extended to GWAS or other types of genomic meta-analysis. The identified problematic studies can be scrutinized to identify technical and biological causes (e.g. sample size, platform, tissue collection, preprocessing etc) of their bad quality or irreproducibility for final inclusion / exclusion decision. standalone software, mac os x, unix/linux, windows, r, FASEB list is listed by: OMICtools
has parent organization: CRAN
PMID:22116060 GNU General Public License, v2 OMICS_04032 https://github.com/donkang34/MetaQC SCR_006000 MetaQC: Objective Quality Control and Inclusion/Exclusion Criteria for Genomic Meta-Analysis, MetaQC: Objective Quality Control and Inclusion / Exclusion Criteria for Genomic Meta-Analysis 2026-09-12 12:56:34 40
ABC (Atlas Based Classification)
 
Resource Report
Resource Website
1+ mentions
ABC (Atlas Based Classification) (RRID:SCR_005981) ABC data processing software, image analysis software, software application, software resource, workflow software A comprehensive processing pipeline developed and used at University of North Carolina and University of Utah for brain MRIs. The processing pipeline includes image registration, filtering, segmentation and inhomogeneity correction. The tool is cross-platform and can be run within 3D Slicer or as a stand-alone program. The image segmentation algorithm is based on the EMS software developed by Koen van Leemput. brain, image, image registration, filter, segmentation, inhomogeneity correction, beta, c++, linux, windows is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is related to: 3D Slicer
is related to: INCF Software Center
has parent organization: University of North Carolina at Chapel Hill; North Carolina; USA
has parent organization: University of Utah; Utah; USA
3D Slicer License nlx_151362 SCR_005981 2026-09-12 12:56:34 3
BrainImage Software
 
Resource Report
Resource Website
1+ mentions
BrainImage Software (RRID:SCR_006139) BrainImage data processing software, image analysis software, image processing software, software application, software resource A multiplatform, highly modular image processing and visualization application which is under development by the Center for Interdisciplinary Brain Sciences Research. The goal of this project is provide a framework application for neuroimaging which facilitates the interchange of software tools developed by researchers. BrainImageJava can: * Delineate ROIs in slices along X, Y, or Z axes, with 3D feedback in the other axes. * Create and display triangular mesh surfaces from MRI volumes. * Draw Surfaces-of-Interest (SOIs) in 3D, and edit them in a planar display. * Set Talairach grid on a volume, export an AC/PC stack, and measure the values within each grid unit. This 3D image processing and analysis program for the Apple Macintosh PowerPC is based on the public domain application, NIH Image. It includes interactive procedures for 3D MRI quantification including semi-automated procedures for removing non-brain tissues from images, fuzzy segmentation of tissue compartments, global or local parcellation (based on the Talairach atlas), region-growing, etc. The last version of the software included multiplatform capability, volume visualization and advanced image analysis tools. mri, segmentation, visualization, volume, neuroimaging, analyze, anatomic, application, artifact removal, image display, java, labeling, macos, mesh generation, microsoft, modeling, magnetic resonance, quantification, region of interest, rendering, spatial transformation, three dimensional display, volume measurement, volumetric analysis, volumetric analysis, windows, platform is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
is listed by: Biositemaps
is related to: NIH Image
has parent organization: Stanford University School of Medicine; California; USA
Human Brain Project GNU General Public License nif-0000-00272 http://spnl.stanford.edu/tools/brainimage.htm SCR_006139 Brain Image, BrainImageJ, BrainImageJava 2026-09-12 12:56:35 8
QCGWAS
 
Resource Report
Resource Website
1+ mentions
QCGWAS (RRID:SCR_006408) QCGWAS software resource Software tools for (automated and manual) quality control of the results of Genome Wide Association Studies. quality control, genome wide association study, windows, os x, r, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:24395754 GNU General Public License, v3 or later OMICS_02203, biotools:qcgwas https://bio.tools/qcgwas SCR_006408 QCGWAS: Quality Control of Genome Wide Association Study results, Quality Control of Genome Wide Association Study 2026-09-12 12:56:39 7
POLGUI - Matlab Polhemus Interface
 
Resource Report
Resource Website
1+ mentions
POLGUI - Matlab Polhemus Interface (RRID:SCR_006752) POLGUI software resource An interface between MATLAB and the Polhemus Fastrak digitizer used to digitize fiducial locations and scalp EEG electrode locations. There are 5 versions all of which work under MATLAB R14 (on both linux and windows platforms), # polgui_ver1_r14 : works with 1 receiver (stylus pen) # polgui_ver2_r14 : works with 2 receivers (including the pen) # polgui_ver3_r14 : works with 3 receivers(including the pen) # polgui_ver4_r14 : works with 4 receivers (including the pen) # polgui_ver5_r14 : Generic version which works with 1/2/3/4 receivers (WARNING: Ver 5 might be buggy; not fully tested) Requirements: MATLAB R14 (Linux/Windows) eeg, meg, electrocorticography, linux, matlab, microsoft, magnetic resonance, posix/unix-like, win32 (ms windows), windows is listed by: NeuroImaging Tools and Resources Collaboratory (NITRC)
has parent organization: SourceForge
BSD License nlx_155915 http://www.nitrc.org/projects/polgui SCR_006752 POLGUI - Matlab GUI for Polhemus Fastrak 2026-09-12 12:56:45 5
RCircos
 
Resource Report
Resource Website
100+ mentions
RCircos (RRID:SCR_003310) software resource Software package that provides a simple and flexible way to generate Circos 2D track plot images for genomic data visualization. The types of plots include: heatmap, histogram, lines, scatterplot, tiles and plot items for further decorations include connector, link (lines and ribbons), and text (gene) label. All functions require only R graphics package that comes with R base installation. standalone software, unix/linux, mac os x, windows, r is listed by: OMICtools
is related to: shinyCircoss
has parent organization: CRAN
has parent organization: Bitbucket
PMID:23937229 Free, Available for download, Freely available OMICS_04661 https://bitbucket.org/henryhzhang/rcircos/ SCR_003310 RCircos: Circos 2D Track Plot 2026-09-12 12:55:55 285
ggbio
 
Resource Report
Resource Website
10+ mentions
ggbio (RRID:SCR_003313) software resource An R package for extending the grammar of graphics for genomic data. The graphics are designed to answer common scientific questions, in particular those often asked of high throughput genomics data. All core Bioconductor data structures are supported, where appropriate. The package supports detailed views of particular genomic regions, as well as genome-wide overviews. Supported overviews include ideograms and grand linear views. High-level plots include sequence fragment length, edge-linked interval to data view, mismatch pileup, and several splicing summaries. standalone software, unix/linux, mac os x, windows, r, infrastructure, visualization, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
PMID:22937822 Free, Available for download, Freely available biotools:ggbio, OMICS_04660 http://www.tengfei.name/ggbio/, https://bio.tools/ggbio SCR_003313 ggbio - Visualization tools for genomic data 2026-09-12 12:55:55 16
PrimerSeq
 
Resource Report
Resource Website
1+ mentions
PrimerSeq (RRID:SCR_003295) PrimerSeq software resource Software that designs RT-PCR primers that evaluate alternative splicing events by incorporating RNA-Seq data. It is particularly advantageous for designing a large number of primers for validating alternative splicing events found in RNA-Seq data. It incorporates RNA-Seq data in the design process to weight exons by their read counts. Essentially, the RNA-Seq data allows primers to be placed using actually expressed transcripts. This could be for a particular cell line or experimental condition, rather than using annotations that incorporate transcripts that are not expressed for the data. Alternatively, you can design primers that are always on constitutive exons. PrimerSeq does not limit the use of gene annotations and can be used for a wide array of species. primer, rna-seq, rt-pcr, windows, mac os x, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: SourceForge
PMID:24747190 Free, Available for download, Freely available biotools:primerseq, OMICS_02328 https://bio.tools/primerseq SCR_003295 Primer Seek in RNA-Seq 2026-09-12 12:55:55 7

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