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URL: http://www.wormbase.org/db/get?name=WBStrain00063358
Proper Citation: RRID:WB-STRAIN:WBStrain00063358
Description: Caenorhabditis elegans with name ahcy-1(syb784 *syb646[ahcy-1(Y145C)::GFP]) I. from WB.
Species: Caenorhabditis elegans
Synonyms: ahcy-1(syb784 *syb646[ahcy-1(Y145C)::GFP]) I.
Notes: Engineered Y145C substitution mutation in endogenously GFP-tagged ahcy-1 locus. ahcy-1(Y145C) mutation mimics the pathogenic human mutation AHCY Y143C. ahcy-1(Y145C) mutants have a prolonged lifespan and are larger than control animals. ahcy-1(Y145C) mutants are fertile and produce a brood of laid and hatched eggs similar to control animals. ahcy-1(Y145C) mutants show a slight increase in SAH and a decrease in SAM levels, leading to an increased SAH to SAM ratio. See WOP122 for control strain. Derived by out-crossing parental strain PHX784 two times to N2. Reference: Thapa P, et al. NPJ Aging. 2023 Dec 5;9(1):27. doi: 10.1038/s41514-023-00125-1. PMID: 38052822.|"Made_by: SunyBiotech"
Affected Gene: WBGene00019322(ahcy-1)
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No rating or validation information has been found for ahcy-1(syb784 *syb646[ahcy-1(Y145C)::GFP]) I..
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Source: Integrated Animals
Source Database: WormBase (WB)
The data sets included in this resource are published in Kravitz et al, 2012. Distinct roles for direct and indirect pathway striatal neurons in reinforcement (Nat. Neurosci).
