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URL: http://mayoresearch.mayo.edu/mayo/research/dickson_lab/
Proper Citation: Mayo Clinic Jacksonville: Neuropathology and Microscopy (RRID:SCR_008753)
Description: A brain bank and laboratory focused on memory and motor disorders. Brains are sent to the laboratory for diagnosis and research for the State of Florida Alzheimer Disease Initiative and for the Society for Progressive Supranuclear Palsy. As part of this brain banking function, fixed and frozen brain samples are obtained at autopsy and sent to the laboratory for diagnostic evaluation and for various types of research studies. The major types of analyses performed on the brain samples include neuro-histology, immunohistochemistry, confocal microscopy, electron microscopy and image analysis, as well as immunoassays. The latter are based upon Western blotting and enzyme linked immunoassays. The laboratory has a specific interest in the interface between normal aging and Alzheimer's disease, as well as in non-Alzheimer's degenerative disorders such as Lewy body dementia, corticobasal degeneration, progressive supranuclear palsy and frontotemporal dementia. The primary focus of research on aging is neuropathologic characterization of brains of individuals who had been prospectively and longitudinally evaluated during life. These studies aim to determine differences in a range of biologic parameters in brains of people with normal cognitive, mild cognitive impairment and dementia. Their focus on Parkinson's disease is to identify preclinical Parkinson's disease in order to develop means for early diagnosis.
Synonyms: Mayo Clinic Jacksonville: Neuropathology Microscopy, Mayo Clinic Florida: Neuropathology and Microscopy, Neuropathology and Microscopy - Dennis W. Dickson, Mayo Clinic Florida: Neuropathology and Microscopy - Dennis W. Dickson
Resource Type: biomaterial supply resource, brain bank, material resource, tissue bank
Keywords: tissue, brain, fixed, frozen, alzheimer's disease, normal aging, memory disorder, motor disorder, parkinson's disease, progressive supranuclear palsy, lewy body disease, corticobasal degeneration, frontotemporal dementia, dementia, mild cognitive impairment, mouse, neurofibrillary degeneration, postmortem, normal control, autopsy
Related Condition: Alzheimer's disease, Aging, Memory disorder, Motor disorder, Parkinson's disease, Progressive Supranuclear Palsy, Lewy Body Disease, Corticobasal Degeneration, Frontotemporal dementia, Dementia, Mild Cognitive Impairment
Funding: NIA P50-AG16574; NIA P50-AG25711; NINDS P50-40256
Resource Name: Mayo Clinic Jacksonville: Neuropathology and Microscopy
Resource ID: SCR_008753
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Source: SciCrunch Registry (RRID:SCR_005400)
Description: Interactive portal for finding and submitting biomedical resources. Resources within SciCrunch have assigned RRIDs which are used to cite resources in scientific manuscripts. SciCrunch Registry, formerly NIF Registry, provides resources catalog. Allows to add new resources. Allows edit existing resources after registration. Curators are tasked with identifying and registering resources, examining data, writing configuration files to index and display data and keeping contents current.
URL: https://rrid.site/rin/sources/SCR_005400
The data sets included in this resource are published in Kravitz et al, 2012. Distinct roles for direct and indirect pathway striatal neurons in reinforcement (Nat. Neurosci).
