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PTEN inhibition improves muscle regeneration in mice fed a high-fat diet.

Zhaoyong Hu | Huiling Wang | In Hee Lee | Swati Modi | Xiaonan Wang | Jie Du | William E Mitch
Diabetes | 2010

Mechanisms impairing wound healing in diabetes are poorly understood. To identify mechanisms, we induced insulin resistance by chronically feeding mice a high-fat diet (HFD). We also examined the regulation of phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) during muscle regeneration because augmented IGF-1 signaling can improve muscle regeneration.

Pubmed ID: 20200318

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: P50 DK64233
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK062828
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK62828
  • Agency: NIDDK NIH HHS, United States
    Id: R37 DK37175
  • Agency: NIDDK NIH HHS, United States
    Id: P50 DK064233
  • Agency: NIDDK NIH HHS, United States
    Id: R37 DK037175

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