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URL: http://www.k4dd.eu/

Proper Citation: Kinetics for Drug Discovery (RRID:SCR_003868)

Description: Project whose goal is to improve understanding of how potential drugs bind with their target, and develop methods and tools to allow researchers to study drug-target interactions with greater ease. These tools would help researchers to determine whether a drug candidate is likely to be safe and effective much earlier in the drug development process. The first goal of the team is to enhance understanding of binding kinetics; exactly how do small molecules interact with their targets? Ultimately, the project aims to develop a range of robust techniques, methods and models that could be easily incorporated into the drug development pathway and enable scientists and drug designers worldwide to reliably predict a molecule's kinetic properties (its "kinotype"). This information will allow drug developers to more easily determine the safety and efficacy of a molecule and will weed out ineffective or unsafe molecules earlier in the drug development process. Eventually, the project also hopes to raise awareness of the importance of considering the kinetic aspects of drug-target interactions throughout drug development.

Abbreviations: K4DD

Resource Type: data or information resource, organization portal, portal, consortium

Keywords: drug-target interaction, drug, drug development, tool development, binding kinetics, small molecule, target, kinotype, kinetics, bind