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URL: https://portal.brain-map.org/genetic-tools/genetic-tools-atlas
Proper Citation: Genetic Tools Atlas (RRID:SCR_025643)
Description: Searchable catalog of enhancer-adeno-associated viruses (AAVs) that have been developed and tested at the Allen Institute for Brain Science. We present a suite of enhancer AAVs that can provide access to specific cell types when delivered to the whole brain. Multiple epigenomic and transcriptomic datasets were interrogated to reveal candidate enhancers that are selectively accessible in particular cell populations. Enhancer AAVs were constructed and screened for desirable expression and a sizeable subset of enhancer AAVs were subjected to further characterization by single cell transcriptomics and/or brain-wide expression imaging in mouse. In the GTA, we present a large toolkit for selective gene expression in cell types of interest. Genetic Tools Atlas is part of the growing Brain Knowledge Platform.
Abbreviations: GTA
Synonyms: Allen Genetic Tools Atlas
Resource Type: atlas, catalog, data or information resource, database
Keywords: enhancer-adeno-associated viruses, enhancer AAVs, mouse transgenes, epifluorescence imaging, serial two-photon tomography, sc/snRNA-seq, genetic tools,
Funding: NIMH 1RF1 MH114126; NIMH 1RF1 MH121274; NIMH 1UF1 MH128339; NIMH 1UG3 MH120095; Paul G. Allen Foundation n/a
Availability: Free, Freely available
Resource Name: Genetic Tools Atlas
Resource ID: SCR_025643
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Source: SciCrunch Registry (RRID:SCR_005400)
Description: Interactive portal for finding and submitting biomedical resources. Resources within SciCrunch have assigned RRIDs which are used to cite resources in scientific manuscripts. SciCrunch Registry, formerly NIF Registry, provides resources catalog. Allows to add new resources. Allows edit existing resources after registration. Curators are tasked with identifying and registering resources, examining data, writing configuration files to index and display data and keeping contents current.
URL: https://rrid.site/rin/sources/SCR_005400
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