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Impaired development of Th2 cells in IL-13-deficient mice.

We report that Th2 cell cultures generated using T cells or splenocytes from IL-13-deficient mice produce significantly reduced levels of IL-4, IL-5, and IL-10 compared with wild-type. In contrast, IL-4 and IL-5 production by mast cells stimulated in vitro with PMA, ionomycin, or IgE cross-linking are unaffected. In vitro Th2 cell differentiation cannot be rescued by the addition of exogenous factors, but in vivo antigen challenge and administration of IL-13 can increase Th2-like cytokine responses as can infection with the parasitic nematode Nippostrongylus brasiliensis. IL-13-deficient mice also have lower basal levels of serum IgE and biased antigen-specific immunoglobulin responses. Thus, IL-13 is an important regulator of Th2 commitment and may therefore play a central role in atopy and infectious diseases.

Pubmed ID: 9768762

Authors

  • McKenzie GJ
  • Emson CL
  • Bell SE
  • Anderson S
  • Fallon P
  • Zurawski G
  • Murray R
  • Grencis R
  • McKenzie AN

Journal

Immunity

Publication Data

September 28, 1998

Associated Grants

  • Agency: Wellcome Trust, Id:

Mesh Terms

  • Animals
  • B-Lymphocytes
  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • Drug Resistance
  • Gene Targeting
  • Immunization
  • Immunoglobulin E
  • Interleukin-13
  • Interleukin-4
  • Interleukin-5
  • Mast Cells
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mutagenesis, Insertional
  • Nematode Infections
  • Neomycin
  • Phosphoglycerate Kinase
  • Receptors, IgE
  • Recombinant Proteins
  • Spleen
  • Th2 Cells