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Pterostilbene prevents hepatocyte epithelial-mesenchymal transition in fructose-induced liver fibrosis through suppressing miR-34a/Sirt1/p53 and TGF-β1/Smads signalling.

British journal of pharmacology | 2019

Excessive fructose consumption is a risk factor for liver fibrosis. Pterostilbene protects against liver fibrosis. Here, we investigated the potential role and the mechanisms underlying the hepatocyte epithelial-mesenchymal transition (EMT) in fructose-induced liver fibrosis and protection by pterostilbene.

Pubmed ID: 30632134 RIS Download

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TGFbeta1 (V) (antibody)

RRID:AB_632486

This unknown targets ND

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E-Cadherin (4A2) (antibody)

RRID:AB_2728770

This monoclonal targets E-Cadherin

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goat anti-rabbit IgG-HRP (antibody)

RRID:AB_631746

This polyclonal targets goat anti-rabbit IgG-HRP

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Smad4 (B-8) (antibody)

RRID:AB_627905

This monoclonal targets Raised against amino acids 1-552 representing full length Smad4 of human origin

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Anti-Smad3 Antibody (38-Q) (antibody)

RRID:AB_1129525

This monoclonal targets Smad3

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GAPDH Antibody (FL-335) (antibody)

RRID:AB_10167668

This polyclonal targets GAPDH

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p53 antibody (antibody)

RRID:AB_11155283

This polyclonal targets p53 antibody

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Smad2 (S-20) (antibody)

RRID:AB_656619

This polyclonal targets SMAD2

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Anti-alpha smooth muscle Actin antibody (antibody)

RRID:AB_2223021

This polyclonal targets alpha smooth muscle Actin

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BRL-3A (cell line)

RRID:CVCL_0606

Cell line BRL-3A is a Spontaneously immortalized cell line with a species of origin Rattus norvegicus (Rat)

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GraphPad Prism (software resource)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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ImageJ (software resource)

RRID:SCR_003070

Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

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SD (organism)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

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Anti-alpha smooth muscle Actin antibody (antibody)

RRID:AB_2223021

This polyclonal targets alpha smooth muscle Actin

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Anti-alpha smooth muscle Actin antibody (antibody)

RRID:AB_2223021

This polyclonal targets alpha smooth muscle Actin

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BRL-3A (cell line)

RRID:CVCL_0606

Cell line BRL-3A is a Spontaneously immortalized cell line with a species of origin Rattus norvegicus (Rat)

View all literature mentions