Searching across hundreds of databases
Skin fibroblasts from a patient with intellectual disability and ring chromosome 22 were reprogrammed into induced pluripotent stem cells (iPSCs) to establish a clonal stem cell lines, IMGTi001-A (iTAF5-29) and IMGTi001-B (iTAF5-32). Because of ring chromosome mitotic instability these cell lines show mosaic karyotypes with 46,XX,r(22) in >83% cells, 45,XX,-22 as minor class and sporadically cells with other karyotypes. Differentiation in derivatives of all three germ layers was shown in teratoma assay for IMGTi001-A, and in embryoid bodies for both cell lines. To our knowledge, human iPSC lines with ring chromosome are described for the first time.
Pubmed ID: 30144655 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This polyclonal secondary targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets TRA-1-81 antibody [TRA-1-81] - Embryonic Stem Cell Marker
View all literature mentionsThis monoclonal targets Human TRA-1-60 (R)
View all literature mentionsThis monoclonal targets SSEA4 antibody [MC813] - Embryonic Stem Cell Marker
View all literature mentionsThis polyclonal targets Nanog
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
