The process by which the somatotrope lineage emerges in the developing pituitary is regulated by the activity of specific signaling and transcription factors expressed during development. We set out to understand the contribution of FOXO1 to that process by using a mouse model in which FOXO1 is prematurely expressed in the pituitary primordium. Expression of FOXO1 in the oral ectoderm as early as embryonic day (e)9.5 resulted in pituitary gland hypoplasia and reduced expression of anterior lobe hormone transcripts at e18.5. Of note, the relative numbers of somatotropes and thyrotropes were also decreased at e18.5. LHX3 and PITX2, markers of pituitary identity, were present in a reduced number of cells during the formation of the Rathke pouch. Thus, premature expression of FOXO1 may affect adoption of pituitary identity during differentiation. Our results demonstrate that the timing of FOXO1 activation affects its role in pituitary gland organogenesis and somatotrope differentiation.
Pubmed ID: 29796621 RIS Download
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This unknown targets HA-tag
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View all literature mentionsThis polyclonal targets prolactin
View all literature mentionsThis polyclonal targets growth hormone
View all literature mentionsThis monoclonal targets Human PITX2
View all literature mentionsThis polyclonal targets PIT1/POU1F1
View all literature mentionsThis polyclonal targets FGFR1
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsThis unknown targets phospho-Histone H3 (Ser10)
View all literature mentionsThis polyclonal targets Mouse Sonic Hedgehog, N-Terminus
View all literature mentionsThis monoclonal targets Active-beta-Catenin
View all literature mentionsThis polyclonal targets TSHβ
View all literature mentionsThis monoclonal targets FoxO1 (C29H4) Rabbit mAb
View all literature mentionsThis polyclonal targets LHβ
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsThis polyclonal targets PIT1/POU1F1
View all literature mentionsThis polyclonal targets LHβ
View all literature mentionsThis polyclonal targets growth hormone
View all literature mentionsThis unknown targets phospho-Histone H3 (Ser10)
View all literature mentionsThis monoclonal targets Human PITX2
View all literature mentionsThis polyclonal targets prolactin
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets TSHβ
View all literature mentionsThis polyclonal targets Mouse Sonic Hedgehog, N-Terminus
View all literature mentionsThis polyclonal targets FGFR1
View all literature mentionsThis monoclonal targets Active-beta-Catenin
View all literature mentionsThis unknown targets HA-tag
View all literature mentionsThis monoclonal targets FoxO1 (C29H4) Rabbit mAb
View all literature mentions