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Accumulation of the β-amyloid peptide (Aβ) is a major pathological hallmark of Alzheimer's disease (AD). Recent studies have shown that synaptic Aβ toxicity may directly impair synaptic function. However, proteins regulating Aβ generation at the synapse have not been characterized. Here, we sought to identify synaptic proteins that interact with the extracellular domain of APP and regulate Aβ generation.
Pubmed ID: 26202512 RIS Download
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Cell line PC12 is a Cancer cell line with a species of origin Rattus norvegicus
View all literature mentionsMus musculus with name Crl:CD1(ICR) from IMSR.
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