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Suppression of protein kinase C theta contributes to enhanced myogenesis in vitro via IRS1 and ERK1/2 phosphorylation.

BMC cell biology | 2013

Differentiation and fusion of skeletal muscle myoblasts into multi-nucleated myotubes is required for neonatal development and regeneration in adult skeletal muscle. Herein, we report novel findings that protein kinase C theta (PKCθ) regulates myoblast differentiation via phosphorylation of insulin receptor substrate-1 and ERK1/2.

Pubmed ID: 24053798 RIS Download

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK020572
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK070127

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C2C12 (tool)

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Cell line C2C12 is a Spontaneously immortalized cell line with a species of origin Mus musculus (Mouse)

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HEK293-FT (tool)

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