TNF-α promotes cerebral pericyte remodeling in vitro, via a switch from α1 to α2 integrins.

There is increasing evidence to suggest that pericytes play a crucial role in regulating the remodeling state of blood vessels. As cerebral pericytes are embedded within the extracellular matrix (ECM) of the vascular basal lamina, it is important to understand how individual ECM components influence pericyte remodeling behavior, and how cytokines regulate these events.

Pubmed ID: 23448258 RIS Download