Preparing your results

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.

Interferon-γ (IFN-γ) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii, a similar population emerged that limited T cell responses and was dependent on IFN-γ in the periphery but on IL-27 at mucosal sites. Transfer of Treg cells ameliorated the infection-induced pathology observed in Il27(-/-) mice, and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-γ or IL-27 have distinct transcriptional profiles. Thus, IFN-γ and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation.

Pubmed ID: 22981537


  • Hall AO
  • Beiting DP
  • Tato C
  • John B
  • Oldenhove G
  • Lombana CG
  • Pritchard GH
  • Silver JS
  • Bouladoux N
  • Stumhofer JS
  • Harris TH
  • Grainger J
  • Wojno ED
  • Wagage S
  • Roos DS
  • Scott P
  • Turka LA
  • Cherry S
  • Reiner SL
  • Cua D
  • Belkaid Y
  • Elloso MM
  • Hunter CA



Publication Data

September 21, 2012

Associated Grants

  • Agency: NIAID NIH HHS, Id: AI 071302
  • Agency: NIAID NIH HHS, Id: AI055428
  • Agency: NIAID NIH HHS, Id: AI084882
  • Agency: NIAID NIH HHS, Id: P01 AI043620
  • Agency: NIAID NIH HHS, Id: R01 AI042334
  • Agency: NIAID NIH HHS, Id: R21-AI090234-01
  • Agency: NIAID NIH HHS, Id: R37-AI28724
  • Agency: NIAID NIH HHS, Id: T32 AI007532
  • Agency: NIAID NIH HHS, Id: T32 AI055400
  • Agency: NIAID NIH HHS, Id: T32 AI055428

Mesh Terms

  • Animals
  • Cell Differentiation
  • Cells, Cultured
  • Female
  • Flow Cytometry
  • Forkhead Transcription Factors
  • Gene Expression Profiling
  • Interferon-gamma
  • Interleukin-17
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred CBA
  • Mice, Knockout
  • Mice, Transgenic
  • Oligonucleotide Array Sequence Analysis
  • Receptors, CXCR3
  • STAT1 Transcription Factor
  • Salmonella Infections, Animal
  • Salmonella typhimurium
  • T-Box Domain Proteins
  • T-Lymphocytes, Regulatory
  • Toxoplasma
  • Toxoplasmosis, Animal