FMRI was used to study the differences of cerebral processing of nociceptive input from the 2nd and the 3rd branches of the trigeminal nerve by electrical stimulation of the tooth pulps of the upper and lower canines. The focus of the study was an investigation of the different levels of the trigeminal system in brainstem, thalamus and in cortical regions which are known to be involved in pain processing. Increased blood oxygen level dependency (BOLD) signals were found ipsilaterally in the trigeminal ganglion and the spinal nucleus (SpV) of the trigeminal nerve. SpV-related activations showed some somatotopic organization. Bilateral activation was found in the structures of the antinociceptive system in the midbrain. Contralateral activations were encountered at the level of the pons. In the thalamus ipsilateral activations were found in the ventral parts. Bilateral activation occurred in the medial dorsal nuclei. At the cortical level BOLD activations were encountered bilaterally in the primary somatosensory cortex (S1, lateral pain system), the cingulate and insular cortex (medial pain system). In the cortex a small difference in the representation of the two trigeminal branches was detected only in S1 on both hemispheres. These findings demonstrate that trigeminal pain markedly activates the lateral and medial pain projection systems and the majority of the affected brain regions showed no difference regarding the input from lower or upper tooth. This lack of discrimination may explain why sometimes it is difficult for patients to locate the exact source of the intraoral clinical pain conditions.
Pubmed ID: 20382476 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Brain Innovation B.V. is developing scientific software in the field of human and animal brain imaging, neural network simulation and computer-based experimental control. Our current major product, BrainVoyager QX, is a commercially available cross-platform neuroimaging tool, which is used in hundreds of labs across the planet. Turbo-BrainVoyager is an easy to use program for real-time data analysis, which allows to observe a subject''s or patient''s brain activity during an ongoing functional MRI scanning session. TMS Neuronavigator provides the hard- and software to navigate a TMS coil to desired anatomical or functionally defined brain regions. We also provide free software products. BrainVoyager Brain Tutor allows to learn about brain areas by clicking on rotatable 3D brain models. StimulDX is a powerful stimulation software based on Microsofts DirectX API, which we will make available for free download in the near future.
View all literature mentions