gpDB - a database of GPCRs G-proteins Effectors and their interactions (RRID:SCR_007063)Copy Citation Copied
URL: http://biophysics.biol.uoa.gr/gpDB/
Proper Citation: gpDB - a database of GPCRs G-proteins Effectors and their interactions (RRID:SCR_007063)
Description: A publicly accessible, relational database of G-proteins and their interactions with GPCRs and effector molecules. The sequences are classified according to a hierarchy of different classes, families and sub-families, based on extensive literature search. There is full sequence information with cross-references to publicly available databases, and the user may submit advanced queries for text search. Furthermore there is an interface for running BLAST against the database and a pattern search tool. The main innovation besides the classification of both G-proteins and GPCRs is the relational model of the database, describing the known coupling specificity of the GPCRs to their respective alpha subunit of G-proteins and also the interaction between G-protein subfamilies and specific effector types, a unique feature not available in any other database. The database will be very useful for the study of G-protein/GPCR and G-protein/effector interactions and for future development of algorithms predicting this interaction.
Abbreviations: gpDB
Synonyms: gpDB: a database of GPCRs G-proteins Effectors and their interactions
Resource Type: analysis service resource, production service resource, database, data or information resource, service resource, data analysis service
Defining Citation: PMID:18441001, PMID:15619328
Keywords: g-protein coupled receptor, g-protein, effector, interaction, effector molecule, algorithm, signal transduction, blast
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University of Athens Biophysics and Bioinformatics Laboratory |
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