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In this fMRI study, we investigated the convergence of underlying neural networks in thinking about a scenario involving one's own intentional action and its consequences and setting up and holding in mind an intention to act. A factorial design was employed comprising two factors: i. Causality (intentional or physical events) and ii. Prospective Memory (present or absent). In each condition, subjects answered questions about various hypothetical scenarios, which related either to the link between the subject's own intentions and consequential actions (Intentional Causality) or to the link between a natural, physical event and its consequences (Physical Causality). A prospective memory task was embedded in half the blocks. In this task, subjects were required to keep in mind an intention (to press a key on seeing a red stimulus background) whilst carrying out the ongoing Causality task. Answering questions about intentional causality versus physical causality activated a network of regions that have traditionally been associated with Theory of Mind, including the medial prefrontal cortex (mPFC), the superior temporal sulcus and the temporal poles bilaterally. In addition, the precuneus bordering with posterior cingulate cortex, an area involved in self-awareness and self-related processing, was activated more when thinking about intentional causality. In the prospective memory task, activations were found in the right parietal cortex, frontopolar cortex (BA 10) and precuneus. Different subregions within the precuneus/posterior cingulate cortex were activated in both main effects of intentional causality and prospective memory. Therefore, the precuneus/posterior cingulate cortex subserves separately thinking about one's own intentions and consequent actions and bearing in mind an intention to make an action. Previous studies have shown that prospective memory, requiring the formation of an intention and the execution of a corresponding action, is associated with decreased activation in the dorsal mPFC, close to the region activated in Theory of Mind tasks. Here, we found that holding in mind an intention to act and at the same time thinking about an intentional action led to reduced activity in a dorsal section of the mPFC. This was a different region from a more anterior, inferior dorsal mPFC region that responded to intentional causality. This suggests that different regions of mPFC play different roles in thinking about intentions.
Recent neuroimaging studies have identified a set of brain regions that are metabolically active during wakeful rest and consistently deactivate in a variety the performance of demanding tasks. This "default network" has been functionally linked to the stream of thoughts occurring automatically in the absence of goal-directed activity and which constitutes an aspect of mental behavior specifically addressed by many meditative practices. Zen meditation, in particular, is traditionally associated with a mental state of full awareness but reduced conceptual content, to be attained via a disciplined regulation of attention and bodily posture. Using fMRI and a simplified meditative condition interspersed with a lexical decision task, we investigated the neural correlates of conceptual processing during meditation in regular Zen practitioners and matched control subjects. While behavioral performance did not differ between groups, Zen practitioners displayed a reduced duration of the neural response linked to conceptual processing in regions of the default network, suggesting that meditative training may foster the ability to control the automatic cascade of semantic associations triggered by a stimulus and, by extension, to voluntarily regulate the flow of spontaneous mentation.
Many theories of communication claim that perspective-taking is a fundamental component of the successful design of utterances for a specific audience. In three experiments, we investigated perspective-taking in a constrained communication situation: Participants played a word guessing game where each trial required them to select a clue word to communicate a single target word to their partner. In many cases, the task requires participants to take the perspective of their partner when generating, evaluating, and selecting potential clue words. For example, if the target word was 'heart', the first word that came to mind might be 'love', but this would not in fact be a very useful clue word. Instead, a word like 'cardiovascular' is much more likely than 'love' to make the partner guess 'heart'. Pairs of participants took turns giving and receiving clues to guess target words, receiving feedback after each trial. In Experiment 1, participants appeared unable to improve their perspective-taking over repeated interactions, despite a baseline performance that suggested strong perspective-taking abilities. In Experiment 2, which included extensive feedback after each trial and only target words for which good clues existed and which required perspective-taking, some measures of perspective-taking showed modest improvements. In Experiment 3, which was conducted online, we used Experiment 2 feedback with Experiment 1 target words. As in Experiment 1, participants did not improve over the course of the game in Experiment 3. The results of these three experiments show quite strong limits on people's ability to adapt and improve perspective-taking without the context provided by interaction history and growing common ground.
We describe BrainSync, an orthogonal transform that allows direct comparison of resting fMRI (rfMRI) time-series across subjects. For this purpose, we exploit the geometry of the rfMRI signal space to propose a novel orthogonal transformation that synchronizes rfMRI time-series across sessions and subjects. When synchronized, rfMRI signals become approximately equal at homologous locations across subjects. The method is based on the observation that rfMRI data exhibit similar connectivity patterns across subjects, as reflected in the pairwise correlations between different brain regions. We show that if the data for two subjects have similar correlation patterns then their time courses can be approximately synchronized by an orthogonal transformation. This transform is unique, invertible, efficient to compute, and preserves the connectivity structure of the original data for all subjects. Analogously to image registration, where we spatially align structural brain images, this temporal synchronization of brain signals across a population, or within-subject across sessions, facilitates cross-sectional and longitudinal studies of rfMRI data. The utility of the BrainSync transform is illustrated through demonstrative simulations and applications including quantification of rfMRI variability across subjects and sessions, cortical functional parcellation across a population, timing recovery in task fMRI data, comparison of task and resting state data, and an application to complex naturalistic stimuli for annotation prediction.
Repetitive negative thinking (RNT) is a transdiagnostic process involved in the onset and maintenance of many psychological disorders. The Perseverative Thinking Questionnaire (Ehring et al., 2011) is a content-independent scale composed of 15 items that assesses RNT from a transdiagnostic perspective in both clinical and general populations. The aim of the current research was to translate and validate the French version of the PTQ through two studies (total N = 1016) following the steps for the trans-cultural validation of psychometric instruments (Hambleton et al., 2006). An exploratory factor analysis conducted on a first community sample revealed a latent structure composed of 10 items distributed on one common factor, labeled RNT, and three subfactors that evaluated the repetitive characteristic of RNT, the intrusiveness of RNT and the effect of RNT on mental resources. This factorial structure was confirmed in two confirmatory factor analyses in community and clinical samples. Scale score reliability indices were good and confirmed the validity of the instrument. The French version of the PTQ is a good content-independent instrument to assess RNT in general and clinical populations of French speakers.
Torrance Test of Creative Thinking is the most widely used form of creativity test. Although creativity assessed using the figural form of Torrance Test of Creative Thinking has been considered non-unidimensional, the structural correlates for each separable dimension have yet to be explored. The present study investigated the underlying cortical structure of separable dimensions for creativity using the figural Torrance Test of Creative Thinking. To this end, we recruited healthy young adults and conducted a regression analysis of the figural Torrance Test of Creative Thinking scores of gray matter volume after factorizing the five subscales using exploratory factor analysis. As a result, two factors of the figural Torrance Test of Creative Thinking were identified: (1) 'FO' factor consisting of fluency and originality and (2) 'RAS' factor consisting resistance to premature closure, abstractness of titles, and sophistication/elaboration. Subsequently, the FO factor showed a positive association with cerebral volumes in the parieto-temporal regions of the left angular gyrus and the right inferior parietal lobule, inferior and middle temporal, and parahippocampal gyri, which overlapped the default network. The RAS factor showed a positive correlation with the fronto-temporal regions including the bilateral temporal area, the left inferior parietal, and the right dorsolateral prefrontal regions representing the semantic control network. Our findings revealed the morphological substrates for the figural Torrance Test of Creative Thinking depending on two creative dimensions. The implications of the results are discussed.
Metacognition supports reflection upon and control of other cognitive processes. Despite metacognition occupying a central role in human psychology, its neural substrates remain underdetermined, partly due to study-specific differences in task domain and type of metacognitive judgement under study. It is also unclear how metacognition relates to other apparently similar abilities that depend on recursive thought such as theory of mind or mentalising. Now that neuroimaging studies of metacognition are more prevalent, we have an opportunity to characterise consistencies in neural substrates identified across different analysis types and domains. Here we used quantitative activation likelihood estimation methods to synthesise findings from 47 neuroimaging studies on metacognition, divided into categories based on the target of metacognitive evaluation (memory and decision-making), analysis type (judgement-related activation, confidence-related activation, and predictors of metacognitive sensitivity), and, for metamemory judgements, temporal focus (prospective and retrospective). A domain-general network, including medial and lateral prefrontal cortex, precuneus, and insula was associated with the level of confidence in self-performance in both decision-making and memory tasks. We found preferential engagement of right anterior dorsolateral prefrontal cortex in metadecision experiments and bilateral parahippocampal cortex in metamemory experiments. Results on metacognitive sensitivity were inconclusive, likely due to fewer studies reporting this contrast. Finally, by comparing our results to meta-analyses of mentalising, we obtain evidence for common engagement of the ventromedial and anterior dorsomedial prefrontal cortex in both metacognition and mentalising, suggesting that these regions may support second-order representations for thinking about the thoughts of oneself and others.
Theories of psychotherapy suggest that human mental problems associate with deficiencies in critical thinking. However, it currently remains unclear whether both critical thinking skill and critical thinking disposition relate to individual differences in mental health. This study explored whether and how the critical thinking ability and critical thinking disposition of university students associate with individual differences in mental health in considering impulsivity that has been revealed to be closely related to both critical thinking and mental health. Regression and structural equation modeling analyses based on a Chinese university student sample (N = 314, 198 females, M age = 18.65) revealed that critical thinking skill and disposition explained a unique variance of mental health after controlling for impulsivity. Furthermore, the relationship between critical thinking and mental health was mediated by motor impulsivity (acting on the spur of the moment) and non-planning impulsivity (making decisions without careful forethought). These findings provide a preliminary account of how human critical thinking associate with mental health. Practically, developing mental health promotion programs for university students is suggested to pay special attention to cultivating their critical thinking dispositions and enhancing their control over impulsive behavior.
Counterfactual thinking (CFT) refers to the generation of mental simulations of alternatives to past events, actions and outcomes. CFT is a pervasive cognitive feature in every-day life and is closely related to decision-making, planning and problem-solving - all of which are cognitive processes linked to unimpaired frontal lobe functioning. Huntington's Disease (HD) is a neurodegenerative disorder characterised by motor, behavioral and cognitive dysfunctions. Because an impairment in frontal and executive functions has been described in HD, we hypothesised that HD patients may have a CFT impairment.
The current study investigated the impact of worry and brooding as moderators of the tripartite model of depression and anxiety (TMDA). We hypothesized that both types of perseverative thinking would moderate the association between negative affectivity (NA) and both anxiety and depression. Complete data sets for this questionnaire survey were obtained from 537 students. Participants' ages ranged from 16 to 49 years with a mean age of 21.1 years (SD = 3.6). Overall, results from path analyses supported the assumptions of the TMDA, in that NA was a non-specific predictor for both depression and anxiety whilst lack of positive affectivity (PA) was related to depression only. Unexpectedly, perseverative thinking had an effect on the dependency of negative and positive affectivity. Worry was a significant moderator for the path NA-anxiety. All other hypothesized associations were only marginally significant. Alternative pathways as well as methodological implications regarding similarities and differences of the two types of perseverative thinking are discussed.
Some experiences linger in mind, spontaneously returning to our thoughts for minutes after their conclusion. Other experiences fall out of mind immediately. It remains unclear why. We hypothesize that an input is more likely to persist in our thoughts when it has been deeply processed: when we have extracted its situational meaning rather than its physical properties or low-level semantics. Here, participants read sequences of words with different levels of coherence (word-, sentence-, or narrative-level). We probe participants' spontaneous thoughts via free word association, before and after reading. By measuring lingering subjectively (via self-report) and objectively (via changes in free association content), we find that information lingers when it is coherent at the narrative level. Furthermore, and an individual's feeling of transportation into reading material predicts lingering better than the material's objective coherence. Thus, our thoughts in the present moment echo prior experiences that have been incorporated into deeper, narrative forms of thinking.
Currently there are definitions from many agencies and research societies defining "bioinformatics" as deriving knowledge from computational analysis of large volumes of biological and biomedical data. Should this be the bioinformatics research focus? We will discuss this issue in this review article. We would like to promote the idea of supporting human-infrastructure (HI) with no-boundary thinking (NT) in bioinformatics (HINT).
Resting-state functional connectivity (RSFC) has been proposed as a potential indicator of repetitive negative thinking (RNT) in depression, while inconsistent findings have been reported. This study utilized connectome-based predictive modeling (CPM) to investigate whether RSFC and negative-thinking-state functional connectivity (NTFC) could predict RNT in individuals with Major Depressive Disorder (MDD). Although RSFC distinguished between healthy and depressed individuals, it did not predict trait RNT (as assessed by the Ruminative Responses Scale-Brooding subscale) in depressed individuals. Conversely, NTFC predicted trait RNT in depressed individuals with significant accuracy, but could not differentiate between healthy and depressed individuals. Connectome-wide analysis revealed that negative thinking in depression was associated with higher FC between default mode and executive control regions, which was not observed in RSFC. Our findings suggest that RNT in depression is associated with an active mental process involving multiple brain regions across functional networks that is not represented in the resting state.
Metacognition is defined as the ability to reflect on one's mental state and to govern thoughts and beliefs. Metacognitive dysfunctions are typical of several psychopathologic conditions, and also a feature of insomnia disorder, possibly playing a crucial role in its genesis and maintenance. In the context of insomnia, metacognition describes how individuals react to their own sleep-related thoughts and beliefs, boosting the hyperarousal state experienced by these patients. Up to now, no studies evaluated the effect of cognitive behavioral therapy for insomnia (CBT-I) on metacognitive functioning. Therefore, the aim of our study was to evaluate the effect of CBT-I administered in group format in patients with insomnia disorder. As expected, all patients showed significant improvements in both insomnia and sleep diary parameters after treatment. Furthermore, an improvement was observed also in dysfunctional metacognitive levels, assessed by means of the Metacognitions Questionnaire-Insomnia (MCQ-I). However, 63% of patients still showed a MCQ-I score above the clinical cutoff after treatment. Dividing the sample on the basis of MCQ-I questionnaire scores after CBT-I, we found that patients, who still presented metacognitive impairment, received significant beneficial effects from CBT-I both on insomnia symptoms and on dysfunctional beliefs, but not on dysfunctional metacognitive functioning. These findings suggest that metacognition should be carefully evaluated in insomnia patients and further studies are needed to evaluate long-term implications of this remaining dysfunction.
Calls for enabling 'critical thinking' are ubiquitous in health professional education. However, there is little agreement in the literature or in practice as to what this term means and efforts to generate a universal definition have found limited traction. Moreover, the variability observed might suggest that multiplicity has value that the quest for universal definitions has failed to capture. In this study, we sought to map the multiple conceptions of critical thinking in circulation in health professional education to understand the relationships and tensions between them.
With the aging of the world population, and improvements in medical and health technologies, there are increasing numbers of elderly patients undergoing anaesthesia and surgery. Perioperative neurocognitive dysfunction has gradually attracted increasing attention from academics. Very recently, 6 well-known journals jointly recommended that the term perioperative neurocognitive dysfunction (defined according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition) should be adopted to improve the quality and consistency of academic communications. Perioperative neurocognitive dysfunction currently includes preoperatively diagnosed cognitive decline, postoperative delirium, delayed neurocognitive recovery, and postoperative cognitive dysfunction. Increasing evidence shows that the gut microbiota plays a pivotal role in neuropsychiatric diseases, and in central nervous system functions via the microbiota-gut-brain axis. We recently reported that abnormalities in the composition of the gut microbiota might underlie the mechanisms of postoperative cognitive dysfunction and postoperative delirium, suggesting a critical role for the gut microbiota in perioperative neurocognitive dysfunction. This article therefore reviewed recent findings on the linkage between the gut microbiota and the underlying mechanisms of perioperative neurocognitive dysfunction.
Empirical studies indicate a link between creativity and schizotypal personality traits, where individuals who score highly on schizotypy measures also display greater levels of creative behaviour. However, the exact nature of this relationship is not yet clear, with only a few studies examining this association using neuroimaging methods. In the present study, the neural substrates of creative thinking were assessed with a drawing task paradigm in healthy individuals using fMRI. These regions were then statistically correlated with the participants' level of schizotypy as measured by the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE), which is a questionnaire consisting of four dimensions. Neural activations associated with the creativity task were observed in bilateral inferior temporal gyri, left insula, left parietal lobule, right angular gyrus, as well as regions in the prefrontal cortex. This widespread pattern of activation suggests that creative thinking utilises multiple neurocognitive networks, with creative production being the result of collaboration between these regions. Furthermore, the correlational analyses found the Unusual Experiences factor of the O-LIFE to be the most common dimension associated with these areas, followed by the Impulsive Nonconformity dimension. These correlations were negative, indicating that individuals who scored the highest in these factors displayed the least amount of activation when performing the creative task. This is in line with the idea that 'less is more' for creativity, where the deactivation of specific cortical areas may facilitate creativity. Thus, these findings contribute to the evidence of a common neural basis between creativity and schizotypy.
Artificial intelligence (AI) is poised to transform breast cancer care. However, most scientists, engineers, and clinicians are not prepared to contribute to the AI revolution in healthcare. In this paper, we describe our experiences teaching a new undergraduate course for American students that aims to prepare the next generation for cross-cultural designthinking, which we believe is crucial for AI to achieve its full potential in breast cancer care.
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