Monoclonal antibodies (mAbs) against a preparation of intermediate filaments from trophoblastoma cells were studied for their reactivity pattern during embryonic development and on adult tissue cells. Up to day 12 of embryonic development, epithelial cells of the three germ layers reacted with these mAbs. Later during development and in adult tissues, positive reactions could be observed only with epithelial cells derived from mesoderm and endoderm. Because of their tissue distribution, the proteins reacting with these mAbs might belong to the keratin family of intermediate filaments or they might represent a new group of intermediate filaments.
Pubmed ID: 6171607 RIS Download
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This monoclonal targets Keratin, type I; cytokeratin 19
View all literature mentionsThis monoclonal targets Keratin, type II; cytokeratin 8/18; EndoA
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