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Developing organisms use fine-tuning mechanisms to adjust body growth to ever-changing nutritional conditions. In Drosophila, the secretory activity of insulin-producing cells (IPCs) is central to couple systemic growth with amino acids availability. Here, we identify a subpopulation of inhibitory neurons contacting the IPCs (IPC-connecting neurons or ICNs) that play a key role in this coupling. We show that ICNs respond to growth-blocking peptides (GBPs), a family of fat-body-derived signals produced upon availability of dietary amino acids. We demonstrate that GBPs are atypical ligands for the fly EGF receptor (EGFR). Upon activation of EGFR by adipose GBPs, ICN-mediated inhibition of IPC function is relieved, allowing insulin secretion. Our study reveals an unexpected role for EGF-like metabolic hormones and EGFR signaling as critical modulators of neural activity, coupling insulin secretion to the nutritional status.
Pubmed ID: 30555002 RIS Download
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This monoclonal targets p44/42 MAPK (Erk1/2)
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View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis monoclonal targets Phospho-Tyrosine (P-Tyr-1000)
View all literature mentionsThis monoclonal targets V5 Tag
View all literature mentionsDrosophila melanogaster with name w[1118]; Gcn5[E333st] P{w[+mW.hs]=FRT(w[hs])}2A e[1]/TM3, P{w[+mC]=ActGFP}JMR2, Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR22H11-lexA}attP40 from BDSC.
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View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=LexAop-CD8-GFP-2A-CD8-GFP}2; P{w[+mC]=UAS-mLexA-VP16-NFAT}H2, P{w[+mC]=lexAop-rCD2-GFP}3/TM6B, Tb[1] from BDSC.
View all literature mentionsCell line S2R+ is a Spontaneously immortalized cell line with a species of origin Drosophila melanogaster (Fruit fly)
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View all literature mentionsDrosophila melanogaster with name w[*]; P{y[+t7.7] w[+mC]=10XUAS-IVS-mCD8::GFP}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-hid.Z}2/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR22H11-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
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View all literature mentionsDrosophila melanogaster with name P{w[+mC]=GAL4-Eh.2.4}C21 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-mCD8.ChRFP}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Hsap\KCNJ2.EGFP}7 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=Ilp2-GAL4.R}2/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=UAS-NaChBac}2 from BDSC.
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View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=Lsp2-GAL4.H}3 from BDSC.
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsCell line S2R+ is a Spontaneously immortalized cell line with a species of origin Drosophila melanogaster (Fruit fly)
View all literature mentionsThis monoclonal targets V5 Tag
View all literature mentionsThis monoclonal targets p44/42 MAPK (Erk1/2)
View all literature mentionsThis monoclonal targets α-Tubulin
View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)
View all literature mentionsThis monoclonal targets Phospho-Tyrosine (P-Tyr-1000)
View all literature mentionsThis polyclonal targets DsRed
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=GAL4-Eh.2.4}C21 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=LexAop-CD8-GFP-2A-CD8-GFP}2; P{w[+mC]=UAS-mLexA-VP16-NFAT}H2, P{w[+mC]=lexAop-rCD2-GFP}3/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR22H11-lexA}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=Lsp2-GAL4.H}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR22H11-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=Ilp2-GAL4.R}2/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsDiscontinued
View all literature mentionsDrosophila melanogaster with name w[*]; P{y[+t7.7] w[+mC]=CoinFLP-LexA::GAD.GAL4}attP40 P{w[+mC]=lexAop-rCD2.RFP}2; P{w[+mC]=UAS-CD4-spGFP1-10}3, P{w[+mC]=lexAop-CD4-spGFP11}3/TM6C, Sb[1] from BDSC.
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View all literature mentionsDrosophila melanogaster with name w[*]; P{y[+t7.7] w[+mC]=10XUAS-IVS-mCD8::GFP}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; Gcn5[E333st] P{w[+mW.hs]=FRT(w[hs])}2A e[1]/TM3, P{w[+mC]=ActGFP}JMR2, Ser[1] from BDSC.
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View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=UAS-NaChBac}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-hid.Z}2/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Hsap\KCNJ2.EGFP}7 from BDSC.
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