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In early mammalian embryos, it remains unclear how the first cell fate bias is initially triggered and amplified toward cell fate segregation. Here, we report that a long noncoding RNA, LincGET, is transiently and asymmetrically expressed in the nucleus of two- to four-cell mouse embryos. Overexpression of LincGET in one of the two-cell blastomeres biases its progeny predominantly toward the inner cell mass (ICM) fate. Mechanistically, LincGET physically binds to CARM1 and promotes the nuclear localization of CARM1, which can further increase the level of H3 methylation at Arginine 26 (H3R26me), activate ICM-specific gene expression, upregulate transposons, and increase global chromatin accessibility. Simultaneous overexpression of LincGET and depletion of Carm1 no longer biased embryonic fate, indicating that the effect of LincGET in directing ICM lineage depends on CARM1. Thus, our data identify LincGET as one of the earliest known lineage regulators to bias cell fate in mammalian 2-cell embryos.
Pubmed ID: 30550787 RIS Download
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Software tool that screens DNA sequences for interspersed repeats and low complexity DNA sequences. The output of the program is a detailed annotation of the repeats that are present in the query sequence as well as a modified version of the query sequence in which all the annotated repeats have been masked (default: replaced by Ns). Currently over 56% of human genomic sequence is identified and masked by the program. Sequence comparisons in RepeatMasker are performed by one of several popular search engines including nhmmer, cross_match, ABBlast/WUBlast, RMBlast and Decypher. RepeatMasker makes use of curated libraries of repeats and currently supports Dfam ( profile HMM library ) and RepBase ( consensus sequence library ).
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View all literature mentionsThis polyclonal targets gamma H2A.X (phospho S139)
View all literature mentionsThis polyclonal targets HA tag - ChIP Grade
View all literature mentionsThis monoclonal targets KMT2H / ASH1 antibody [ASH5H03]
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View all literature mentionsThis polyclonal targets SUZ12 - ChIP Grade
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View all literature mentionsThis polyclonal targets HDAC1 - ChIP Grade
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View all literature mentionsThis monoclonal targets YY1 antibody [EPR4652]
View all literature mentionsThis polyclonal targets EDR1 / PHC1 antibody
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View all literature mentionsThis polyclonal targets CDYL antibody - ChIP Grade
View all literature mentionsThis monoclonal targets Tubulin
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis polyclonal targets Oct-3/4
View all literature mentionsThis polyclonal targets SOX21
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis polyclonal targets KMT6
View all literature mentionsThis polyclonal targets Human cbx2
View all literature mentionsThis polyclonal targets HDAC1 - ChIP Grade
View all literature mentionsThis monoclonal targets KMT2H / ASH1 antibody [ASH5H03]
View all literature mentionsThis monoclonal targets Tubulin
View all literature mentionsThis polyclonal targets Sox-2 (D-17)
View all literature mentionsThis monoclonal targets CARM1
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets BRG1 - ChIP Grade
View all literature mentionsThis monoclonal targets KMT2A / MLL antibody [mmN4.4]
View all literature mentionsThis polyclonal targets Human KDM5C / Jarid1C / SMCX
View all literature mentionsThis monoclonal targets KDM3A / JHDM2A antibody [14F8]
View all literature mentionsThis polyclonal targets EDR1 / PHC1 antibody
View all literature mentionsThis polyclonal targets EED antibody
View all literature mentionsThis polyclonal targets KMT1C / G9a antibody - ChIP Grade
View all literature mentionsThis polyclonal targets CDYL antibody - ChIP Grade
View all literature mentionsThis polyclonal targets SUZ12 - ChIP Grade
View all literature mentionsThis polyclonal targets Biotin
View all literature mentionsThis polyclonal targets RING1
View all literature mentionsThis monoclonal targets YY1 antibody [EPR4652]
View all literature mentionsThis polyclonal targets Human REST / NRSF
View all literature mentionsThis polyclonal targets HA tag - ChIP Grade
View all literature mentionsThis polyclonal targets SOX21
View all literature mentionsThis polyclonal targets Oct-3/4
View all literature mentionsThis monoclonal targets Human CDX2
View all literature mentionsThis polyclonal targets H3R26me2
View all literature mentionsThis polyclonal targets gamma H2A.X (phospho S139)
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