There is a considerable need to identify those individuals with prostate cancer who have indolent disease. We propose that genes that control adult stem cell homeostasis in organs with slow turnover, such as the prostate, control cancer fate. One such gene, KLF4, overexpressed in murine prostate stem cells, regulates their homeostasis, blocks malignant transformation, and controls the self-renewal of tumor-initiating cells. KLF4 loss induces the molecular features of aggressive cancer and converts PIN lesions to invasive sarcomatoid carcinomas; its re-expression in vivo reverses this process. Bioinformatic analysis links these changes to human cancer. KLF4 and its downstream targets make up a gene signature that identifies indolent tumors and predicts recurrence-free survival. This approach may improve prognosis and identify therapeutic targets for advanced cancer.
Pubmed ID: 30540935 RIS Download
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View all literature mentionsMus musculus with name C57BL/6J from IMSR.
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View all literature mentionsThis unknown targets Rabbit IgG (H+L)
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View all literature mentionsThis unknown targets Mouse IgG (H+L)
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View all literature mentionsThis polyclonal targets Goat Mouse IgG HRP Affinity Purified PAb
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View all literature mentionsThis polyclonal targets Goat Mouse IgG HRP Affinity Purified PAb
View all literature mentionsThis polyclonal targets Mouse KLF4
View all literature mentionsThis monoclonal targets Snai1
View all literature mentionsThis recombinant monoclonal targets Ki67
View all literature mentionsThis monoclonal targets E-Cadherin (24E10) Rabbit mAb
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis monoclonal targets Human Cytokeratin-8 (HK-8)
View all literature mentionsThis monoclonal targets Ly-6A/E
View all literature mentionsThis polyclonal targets Keratin 5 Purified
View all literature mentionsThis monoclonal targets CD49f
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis polyclonal targets Rabbit IgG
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
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