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The transcription factors TFE3 and TFEB cooperate to regulate autophagy induction and lysosome biogenesis in response to starvation. Here we demonstrate that DNA damage activates TFE3 and TFEB in a p53 and mTORC1 dependent manner. RNA-Seq analysis of TFEB/TFE3 double-knockout cells exposed to etoposide reveals a profound dysregulation of the DNA damage response, including upstream regulators and downstream p53 targets. TFE3 and TFEB contribute to sustain p53-dependent response by stabilizing p53 protein levels. In TFEB/TFE3 DKOs, p53 half-life is significantly decreased due to elevated Mdm2 levels. Transcriptional profiles of genes involved in lysosome membrane permeabilization and cell death pathways are dysregulated in TFEB/TFE3-depleted cells. Consequently, prolonged DNA damage results in impaired LMP and apoptosis induction. Finally, expression of multiple genes implicated in cell cycle control is altered in TFEB/TFE3 DKOs, revealing a previously unrecognized role of TFEB and TFE3 in the regulation of cell cycle checkpoints in response to stress.
Pubmed ID: 30520728 RIS Download
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A contract research organization providing drug development and animal testing services. Under the name Covance Research Products Inc., based in Denver, Pennsylvania, the company also deals in the import, breeding and sale of laboratory animals. It breeds dogs, rabbits, guinea pigs, non-human primates, and pigs, and runs the largest non-human primate laboratory in Germany. (Wikipedia)
View all literature mentionsGlobal nonprofit biological resource center (BRC) and research organization that provides biological products, technical services and educational programs to private industry, government and academic organizations. Its mission is to acquire, authenticate, preserve, develop and distribute biological materials, information, technology, intellectual property and standards for the advancement and application of scientific knowledge. The primary purpose of ATCC is to use its resources and experience as a BRC to become the world leader in standard biological reference materials management, intellectual property resource management and translational research as applied to biomaterial development, standardization and certification. ATCC characterizes cell lines, bacteria, viruses, fungi and protozoa, as well as develops and evaluates assays and techniques for validating research resources and preserving and distributing biological materials to the public and private sector research communities.
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View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
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View all literature mentionsCell line RAW 264.7 is a Cancer cell line with a species of origin Mus musculus
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets rat IgG HRP-linked
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal targets cdc2, Cyclin-dependent kinase 1
View all literature mentionsThis unknown targets NPM
View all literature mentionsThis monoclonal targets Phospho-cdc2 (Tyr15)
View all literature mentionsThis unknown targets NPM, phospho (Thr199)
View all literature mentionsThis monoclonal targets Chek1
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets Phospho-Rb (Ser807/811) (D20B12) XP Rabbit mAb
View all literature mentionsThis monoclonal targets CDK4
View all literature mentionsThis unknown targets Phospho-p130 (Ser639)
View all literature mentionsThis polyclonal targets Caspase-3
View all literature mentionsThis monoclonal targets Chk1, phospho (Ser345)
View all literature mentionsThis polyclonal targets Phospho-p53 (Ser15)
View all literature mentionsThis monoclonal targets 4E-BP1, phospho (Thr37 / Thr46)
View all literature mentionsThis polyclonal targets Phospho-p53 (Ser392)
View all literature mentionsThis monoclonal targets 4E-BP1 (53H11) Rabbit mAb
View all literature mentionsThis polyclonal targets Acetyl-p53 (Lys379)
View all literature mentionsThis polyclonal targets MDM2
View all literature mentionsThis monoclonal targets p70 S6 Kinase
View all literature mentionsThis monoclonal targets LAMP-1 (mouse)
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Phospho-p70 S6 Kinase (Thr389)
View all literature mentionsThis unknown targets Human TFE3
View all literature mentionsCell line HeLa is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line ARPE-19 is a Spontaneously immortalized cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis unknown targets
View all literature mentionsCell line ARPE-19 is a Spontaneously immortalized cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HeLa is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsThis unknown targets Human TFE3
View all literature mentionsThis monoclonal targets p70 S6 Kinase
View all literature mentionsThis monoclonal targets 4E-BP1 (53H11) Rabbit mAb
View all literature mentionsThis monoclonal targets LAMP-1 (mouse)
View all literature mentionsThis polyclonal targets Phospho-p70 S6 Kinase (Thr389)
View all literature mentionsThis polyclonal targets Acetyl-p53 (Lys379)
View all literature mentionsThis polyclonal targets Phospho-p53 (Ser15)
View all literature mentionsThis polyclonal targets Caspase-3
View all literature mentionsThis polyclonal targets Phospho-p53 (Ser392)
View all literature mentionsThis polyclonal targets MDM2
View all literature mentionsThis monoclonal targets CDK4
View all literature mentionsThis monoclonal targets 4E-BP1, phospho (Thr37 / Thr46)
View all literature mentionsThis unknown targets NPM
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis monoclonal targets Chek1
View all literature mentionsThis monoclonal targets Phospho-Rb (Ser807/811) (D20B12) XP Rabbit mAb
View all literature mentionsThis monoclonal targets Chk1, phospho (Ser345)
View all literature mentionsThis unknown targets Phospho-p130 (Ser639)
View all literature mentionsThis monoclonal targets Phospho-cdc2 (Tyr15)
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets NPM, phospho (Thr199)
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis polyclonal targets cdc2, Cyclin-dependent kinase 1
View all literature mentionsThis polyclonal targets rat IgG HRP-linked
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
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