The oral mucosa is one of the most rapidly dividing tissues in the body and serves as a barrier to physical and chemical insults from mastication, food, and microorganisms. Breakdown of this barrier can lead to significant morbidity and potentially life-threatening infections for patients. Determining the identity and organization of oral epithelial progenitor cells (OEPCs) is therefore paramount to understanding their roles in homeostasis and disease. Using lineage tracing and label retention experiments, we show that rapidly dividing OEPCs are located broadly within the basal layer of the mucosa throughout the oral cavity. Quantitative clonal analysis demonstrated that OEPCs undergo population-asymmetrical divisions following neutral drift dynamics and that they respond to chemotherapy-induced damage by altering daughter cell fates. Finally, using single-cell RNA-seq, we establish the basal layer population structure and propose a model that defines the organization of cells within the basal layer.
Pubmed ID: 30472156 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Imaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsThis monoclonal targets Bmi1 (D42B3) Rabbit mAb
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal targets CD104
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets KLH
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsThis unknown targets Keratin 14
View all literature mentionsThis monoclonal targets CD104
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets p53
View all literature mentionsThis monoclonal targets Ki67
View all literature mentionsThis polyclonal targets Rabbit IgG (H+L)
View all literature mentionsMus musculus with name STOCK Lrig1tm1.1(cre/ERT2)Rjc/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name B6;129-Bmi1tm1(cre/ERT)Mrc/J from IMSR.
View all literature mentionsVector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.
View all literature mentionsMus musculus with name STOCK Tg(KRT14-cre/ERT)20Efu/J from IMSR.
View all literature mentionsMus musculus with name STOCK Gli1tm3(cre/ERT2)Alj/J from IMSR.
View all literature mentionsProgramming language for all operating systems that lets users work more quickly and integrate their systems more effectively. Often compared to Tcl, Perl, Ruby, Scheme or Java. Some of its key distinguishing features include very clear and readable syntax, strong introspection capabilities, intuitive object orientation, natural expression of procedural code, full modularity, exception-based error handling, high level dynamic data types, extensive standard libraries and third party modules for virtually every task, extensions and modules easily written in C, C (or Java for Python, or .NET languages for IronPython), and embeddable within applications as a scripting interface.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J from IMSR.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsMus musculus with name B6;129S-Sox2tm1(cre/ERT2)Hoch/J from IMSR.
View all literature mentionsProgramming language for all operating systems that lets users work more quickly and integrate their systems more effectively. Often compared to Tcl, Perl, Ruby, Scheme or Java. Some of its key distinguishing features include very clear and readable syntax, strong introspection capabilities, intuitive object orientation, natural expression of procedural code, full modularity, exception-based error handling, high level dynamic data types, extensive standard libraries and third party modules for virtually every task, extensions and modules easily written in C, C (or Java for Python, or .NET languages for IronPython), and embeddable within applications as a scripting interface.
View all literature mentionsVector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsMus musculus with name STOCK Tg(tetO-HIST1H2BJ/GFP)47Efu/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(KRT14-cre/ERT)20Efu/J from IMSR.
View all literature mentionsMus musculus with name STOCK Lrig1tm1.1(cre/ERT2)Rjc/J from IMSR.
View all literature mentionsMus musculus with name STOCK Gli1tm3(cre/ERT2)Alj/J from IMSR.
View all literature mentionsMus musculus with name B6;129S-Sox2tm1(cre/ERT2)Hoch/J from IMSR.
View all literature mentionsMus musculus with name B6;129-Bmi1tm1(cre/ERT)Mrc/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis monoclonal targets p53
View all literature mentionsThis monoclonal targets Bmi1 (D42B3) Rabbit mAb
View all literature mentionsThis monoclonal targets CD104
View all literature mentionsThis monoclonal targets Ki67
View all literature mentionsThis monoclonal targets CD104
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis monoclonal targets KLH
View all literature mentionsThis polyclonal targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets BrdU
View all literature mentionsThis unknown targets Keratin 14
View all literature mentionsThis monoclonal targets BrdU
View all literature mentions