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Hypoglycaemic effects of glimepiride in sulfonylurea receptor 1 deficient rat.

British journal of pharmacology | 2019

Sulfonylureas (SUs) have been suggested to have an insulin-independent blood glucose-decreasing activity due to an extrapancreatic effect. However, a lack of adequate in vivo evidence makes this statement controversial. Here, we aimed to evaluate whether glimepiride has extrapancreatic blood glucose-lowering activity in vivo.

Pubmed ID: 30471094 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

None found

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


Phospho-Glycogen Synthase (Ser641) Antibody (antibody)

RRID:AB_2116390

This polyclonal targets Glycogen Synthase, phospho (Ser641)

View all literature mentions

Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (antibody)

RRID:AB_331253

This monoclonal targets Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb

View all literature mentions

Akt (pan) (C67E7) Rabbit mAb (antibody)

RRID:AB_915783

This monoclonal targets Akt (pan) (C67E7) Rabbit mAb

View all literature mentions

Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (antibody)

RRID:AB_2315049

This monoclonal targets Phospho-Akt (Ser473)

View all literature mentions

Phospho-GSK-3alpha/beta (Ser21/9) Antibody (antibody)

RRID:AB_329830

This polyclonal targets Phospho-GSK-3alpha/beta (Ser21/9)

View all literature mentions

IRS-1 Antibody (antibody)

RRID:AB_330333

This polyclonal targets IRS-1

View all literature mentions

GSK-3alpha/beta (D75D3) XP Rabbit mAb (antibody)

RRID:AB_10547140

This monoclonal targets GSK-3alpha/beta

View all literature mentions

AMPK alpha (D5A2) Rabbit mAb (antibody)

RRID:AB_10622186

This monoclonal targets AMPK alpha

View all literature mentions

Insulin Receptor β (4B8) Rabbit mAb (antibody)

RRID:AB_2280448

This recombinant monoclonal targets Insulin Receptor beta

View all literature mentions

Glycogen Synthase Antibody (antibody)

RRID:AB_2279563

This polyclonal targets Glycogen Synthase

View all literature mentions

glucose-6-phosphatase, catalytic subunit antibody (antibody)

RRID:AB_1860503

This polyclonal targets glucose-6-phosphatase, catalytic subunit

View all literature mentions

anti-PPAR gamma antibody (antibody)

RRID:AB_2751013

This monoclonal targets PPAR

View all literature mentions

PCK1 antibody (antibody)

RRID:AB_2160031

This polyclonal targets PCK1

View all literature mentions

Anti-rabbit IgG, HRP-linked Antibody (antibody)

RRID:AB_2099233

This polyclonal secondary targets IgG

View all literature mentions

Beta Actin antibody (antibody)

RRID:AB_2289225

This monoclonal targets Beta Actin

View all literature mentions

Crl:CD(SD) (organism)

RRID:RGD_734476

Rattus norvegicus with name Crl:CD(SD) from RGD.

View all literature mentions

Entrez Gene (data or information resource)

RRID:SCR_002473

Database for genomes that have been completely sequenced, have active research community to contribute gene-specific information, or that are scheduled for intense sequence analysis. Includes nomenclature, map location, gene products and their attributes, markers, phenotypes, and links to citations, sequences, variation details, maps, expression, homologs, protein domains and external databases. All entries follow NCBI's format for data collections. Content of Entrez Gene represents result of curation and automated integration of data from NCBI's Reference Sequence project (RefSeq), from collaborating model organism databases, and from many other databases available from NCBI. Records are assigned unique, stable and tracked integers as identifiers. Content is updated as new information becomes available.

View all literature mentions

SPSS (software resource)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

View all literature mentions

Entrez Gene (data or information resource)

RRID:SCR_002473

Database for genomes that have been completely sequenced, have active research community to contribute gene-specific information, or that are scheduled for intense sequence analysis. Includes nomenclature, map location, gene products and their attributes, markers, phenotypes, and links to citations, sequences, variation details, maps, expression, homologs, protein domains and external databases. All entries follow NCBI's format for data collections. Content of Entrez Gene represents result of curation and automated integration of data from NCBI's Reference Sequence project (RefSeq), from collaborating model organism databases, and from many other databases available from NCBI. Records are assigned unique, stable and tracked integers as identifiers. Content is updated as new information becomes available.

View all literature mentions

GSK-3alpha/beta (D75D3) XP Rabbit mAb (antibody)

RRID:AB_10547140

This monoclonal targets GSK-3alpha/beta

View all literature mentions

Crl:CD(SD) (organism)

RRID:RGD_734476

Rattus norvegicus with name Crl:CD(SD) from RGD.

View all literature mentions

Phospho-GSK-3alpha/beta (Ser21/9) Antibody (antibody)

RRID:AB_329830

This polyclonal targets Phospho-GSK-3alpha/beta (Ser21/9)

View all literature mentions

IRS-1 Antibody (antibody)

RRID:AB_330333

This polyclonal targets IRS-1

View all literature mentions

Beta Actin antibody (antibody)

RRID:AB_2289225

This monoclonal targets Beta Actin

View all literature mentions

Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (antibody)

RRID:AB_2315049

This monoclonal targets Phospho-Akt (Ser473)

View all literature mentions

Insulin Receptor β (4B8) Rabbit mAb (antibody)

RRID:AB_2280448

This recombinant monoclonal targets Insulin Receptor beta

View all literature mentions

Phospho-Glycogen Synthase (Ser641) Antibody (antibody)

RRID:AB_2116390

This polyclonal targets Glycogen Synthase, phospho (Ser641)

View all literature mentions

Glycogen Synthase Antibody (antibody)

RRID:AB_2279563

This polyclonal targets Glycogen Synthase

View all literature mentions

Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (antibody)

RRID:AB_331253

This monoclonal targets Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb

View all literature mentions

Anti-rabbit IgG, HRP-linked Antibody (antibody)

RRID:AB_2099233

This polyclonal secondary targets IgG

View all literature mentions

glucose-6-phosphatase, catalytic subunit antibody (antibody)

RRID:AB_1860503

This polyclonal targets glucose-6-phosphatase, catalytic subunit

View all literature mentions

PCK1 antibody (antibody)

RRID:AB_2160031

This polyclonal targets PCK1

View all literature mentions

anti-PPAR gamma antibody (antibody)

RRID:AB_2751013

This monoclonal targets PPAR

View all literature mentions

Akt (pan) (C67E7) Rabbit mAb (antibody)

RRID:AB_915783

This monoclonal targets Akt (pan) (C67E7) Rabbit mAb

View all literature mentions

AMPK alpha (D5A2) Rabbit mAb (antibody)

RRID:AB_10622186

This monoclonal targets AMPK alpha

View all literature mentions

SPSS (software resource)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

View all literature mentions

anti-PPAR gamma antibody (antibody)

RRID:AB_2751013

This monoclonal targets PPAR

View all literature mentions

AMPK alpha (D5A2) Rabbit mAb (antibody)

RRID:AB_10622186

This monoclonal targets AMPK alpha

View all literature mentions

Akt (pan) (C67E7) Rabbit mAb (antibody)

RRID:AB_915783

This monoclonal targets Akt (pan) (C67E7) Rabbit mAb

View all literature mentions

SPSS (software resource)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

View all literature mentions

Anti-rabbit IgG, HRP-linked Antibody (antibody)

RRID:AB_2099233

This polyclonal secondary targets IgG

View all literature mentions

Beta Actin antibody (antibody)

RRID:AB_2289225

This monoclonal targets Beta Actin

View all literature mentions

PCK1 antibody (antibody)

RRID:AB_2160031

This polyclonal targets PCK1

View all literature mentions

glucose-6-phosphatase, catalytic subunit antibody (antibody)

RRID:AB_1860503

This polyclonal targets glucose-6-phosphatase, catalytic subunit

View all literature mentions

IRS-1 Antibody (antibody)

RRID:AB_330333

This polyclonal targets IRS-1

View all literature mentions

Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb (antibody)

RRID:AB_331253

This monoclonal targets Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb

View all literature mentions

Insulin Receptor β (4B8) Rabbit mAb (antibody)

RRID:AB_2280448

This recombinant monoclonal targets Insulin Receptor beta

View all literature mentions

Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (antibody)

RRID:AB_2315049

This monoclonal targets Phospho-Akt (Ser473)

View all literature mentions

Phospho-Glycogen Synthase (Ser641) Antibody (antibody)

RRID:AB_2116390

This polyclonal targets Glycogen Synthase, phospho (Ser641)

View all literature mentions

Glycogen Synthase Antibody (antibody)

RRID:AB_2279563

This polyclonal targets Glycogen Synthase

View all literature mentions

Phospho-GSK-3alpha/beta (Ser21/9) Antibody (antibody)

RRID:AB_329830

This polyclonal targets Phospho-GSK-3alpha/beta (Ser21/9)

View all literature mentions

GSK-3alpha/beta (D75D3) XP Rabbit mAb (antibody)

RRID:AB_10547140

This monoclonal targets GSK-3alpha/beta

View all literature mentions

Crl:CD(SD) (organism)

RRID:RGD_734476

Rattus norvegicus with name Crl:CD(SD) from RGD.

View all literature mentions

Entrez Gene (data or information resource)

RRID:SCR_002473

Database for genomes that have been completely sequenced, have active research community to contribute gene-specific information, or that are scheduled for intense sequence analysis. Includes nomenclature, map location, gene products and their attributes, markers, phenotypes, and links to citations, sequences, variation details, maps, expression, homologs, protein domains and external databases. All entries follow NCBI's format for data collections. Content of Entrez Gene represents result of curation and automated integration of data from NCBI's Reference Sequence project (RefSeq), from collaborating model organism databases, and from many other databases available from NCBI. Records are assigned unique, stable and tracked integers as identifiers. Content is updated as new information becomes available.

View all literature mentions