Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-protein, high-carbohydrate (LPHC) diets also extend lifespan, but it is not known whether they are beneficial for brain health. We compared hippocampus biology and memory in mice subjected to 20% CR or provided ad libitum access to one of three LPHC diets or to a control diet. Patterns of RNA expression in the hippocampus of 15-month-old mice were similar between mice fed CR and LPHC diets when we looked at genes associated with longevity, cytokines, and dendrite morphogenesis. Nutrient-sensing proteins, including SIRT1, mTOR, and PGC1α, were also influenced by diet; however, the effects varied by sex. CR and LPHC diets were associated with increased dendritic spines in dentate gyrus neurons. Mice fed CR and LPHC diets had modest improvements in the Barnes maze and novel object recognition. LPHC diets recapitulate some of the benefits of CR on brain aging.
Pubmed ID: 30463018 RIS Download
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Collection of annotated and manually curated data of genes related to aging divided into genes related to longevity and/or aging in model organisms (yeast, worms, flies, mice, etc.) and aging related human genes.
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View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets The initial immunization was performed with a preparation of full length human recombinant GFAP expressed in bacteria and highly purified
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis polyclonal targets PGC1 alpha
View all literature mentionsThis polyclonal targets GAPDH
View all literature mentionsThis monoclonal targets mTOR
View all literature mentionsThis polyclonal targets Drebrin antibody
View all literature mentionsThis monoclonal targets beta-Actin
View all literature mentionsThis monoclonal targets
View all literature mentionsThis monoclonal targets mTOR
View all literature mentionsThis monoclonal targets beta-Actin
View all literature mentionsThis polyclonal targets GAPDH
View all literature mentionsThis polyclonal targets Drebrin antibody
View all literature mentionsThis monoclonal targets
View all literature mentionsThis polyclonal targets PGC1 alpha
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis unknown targets The initial immunization was performed with a preparation of full length human recombinant GFAP expressed in bacteria and highly purified
View all literature mentions