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Sirtuin 1 represses PKC-ζ activity through regulating interplay of acetylation and phosphorylation in cardiac hypertrophy.

British journal of pharmacology | 2019

Activation of PKC-ζ is closely linked to the pathogenesis of cardiac hypertrophy. PKC-ζ can be activated by certain lipid metabolites such as phosphatidylinositol (3,4,5)-trisphosphate and ceramide. However, its endogenous negative regulators are not well defined. Here, the role of the sirtuin1-PKC-ζ signalling axis and the underlying molecular mechanisms were investigated in cardiac hypertrophy.

Pubmed ID: 30414383 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

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This is a list of tools and resources that we have found mentioned in this publication.


PKC zeta (H-1) (antibody)

RRID:AB_628148

This monoclonal targets PRKCZ

View all literature mentions

PDK1 Antibody (antibody)

RRID:AB_2236832

This unknown targets PDK1

View all literature mentions

Phospho-PDK1 (Ser241) Antibody (antibody)

RRID:AB_2161919

This unknown targets PDK1, phospho (Ser241)

View all literature mentions

SirT1 (1F3) (antibody)

RRID:AB_10999470

This monoclonal targets SirT1

View all literature mentions

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (antibody)

RRID:AB_2315112

This monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)

View all literature mentions

Acetylated-Lysine Antibody (antibody)

RRID:AB_331805

This polyclonal targets Acetylated-Lysine

View all literature mentions

p44/42 MAPK (Erk1/2) Antibody (antibody)

RRID:AB_330744

This polyclonal targets p44/42 MAPK (Erk1/2)

View all literature mentions

Anti-mouse IgG (H+L), F(ab')2 Fragment (Alexa Fluor 555 Conjugate) (antibody)

RRID:AB_1904022

This unknown targets mouse IgG (H+L) F(ab')2 Fragment (Alexa Fluor 555 Conjugate)

View all literature mentions

phospho-PKC ζ (pThr410) (antibody)

RRID:AB_2750603

This polyclonal targets phospho-PKC ζ (pThr410)

View all literature mentions

Monoclonal Anti-Myosin (Skeletal, Slow) antibody produced in mouse (antibody)

RRID:AB_477248

This monoclonal targets Myosin (Skeletal Slow) antibody produced in mouse

View all literature mentions

ERK5 antibody [EP791Y] (antibody)

RRID:AB_732214

This monoclonal targets ERK5 antibody [EP791Y]

View all literature mentions

Vevo 2100 (software resource)

RRID:SCR_015816

Imaging software for high-frequency processing and analysis. Some of its features include modes for blood flow quantification, single line acquisition, 3D-Mode imaging & volume analysis, nonlinear contrast imaging, and other image processing functions.

View all literature mentions

SD (organism)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

View all literature mentions

Quantity One 1-D Analysis Software (software resource)

RRID:SCR_016622

Software used for Bio-Rad imaging systems to acquire, quantitate, and analyze a variety of data. The software allows automatic configuration of imaging systems with appropriate filters, lasers, LEDs, and other illumination sources. It also contains tools for automated analysis of tests and assays such as 1-D electrophoretic gels, western blots, and colony counts.

View all literature mentions

ERK5 antibody [EP791Y] (antibody)

RRID:AB_732214

This monoclonal targets ERK5 antibody [EP791Y]

View all literature mentions

Monoclonal Anti-Myosin (Skeletal, Slow) antibody produced in mouse (antibody)

RRID:AB_477248

This monoclonal targets Myosin (Skeletal Slow) antibody produced in mouse

View all literature mentions

phospho-PKC ζ (pThr410) (antibody)

RRID:AB_2750603

This polyclonal targets phospho-PKC ζ (pThr410)

View all literature mentions

Phospho-PDK1 (Ser241) Antibody (antibody)

RRID:AB_2161919

This unknown targets PDK1, phospho (Ser241)

View all literature mentions

Acetylated-Lysine Antibody (antibody)

RRID:AB_331805

This polyclonal targets Acetylated-Lysine

View all literature mentions

p44/42 MAPK (Erk1/2) Antibody (antibody)

RRID:AB_330744

This polyclonal targets p44/42 MAPK (Erk1/2)

View all literature mentions

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (antibody)

RRID:AB_2315112

This monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)

View all literature mentions

Quantity One 1-D Analysis Software (software resource)

RRID:SCR_016622

Software used for Bio-Rad imaging systems to acquire, quantitate, and analyze a variety of data. The software allows automatic configuration of imaging systems with appropriate filters, lasers, LEDs, and other illumination sources. It also contains tools for automated analysis of tests and assays such as 1-D electrophoretic gels, western blots, and colony counts.

View all literature mentions

SirT1 (1F3) (antibody)

RRID:AB_10999470

This monoclonal targets SirT1

View all literature mentions

Anti-mouse IgG (H+L), F(ab')2 Fragment (Alexa Fluor 555 Conjugate) (antibody)

RRID:AB_1904022

This unknown targets mouse IgG (H+L) F(ab')2 Fragment (Alexa Fluor 555 Conjugate)

View all literature mentions

PKC zeta (H-1) (antibody)

RRID:AB_628148

This monoclonal targets PRKCZ

View all literature mentions

PDK1 Antibody (antibody)

RRID:AB_2236832

This unknown targets PDK1

View all literature mentions

Vevo 2100 (software resource)

RRID:SCR_015816

Imaging software for high-frequency processing and analysis. Some of its features include modes for blood flow quantification, single line acquisition, 3D-Mode imaging & volume analysis, nonlinear contrast imaging, and other image processing functions.

View all literature mentions

SD (organism)

RRID:RGD_70508

Rattus norvegicus with name SD from RGD.

View all literature mentions