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Planar polarity, the coordinated polarization of cells in the plane of a tissue, is important for normal tissue development and function. Proteins of the core planar polarity pathway become asymmetrically localized at the junctions between cells to form intercellular complexes that coordinate planar polarity between cell neighbors. Here, we combine tools to rapidly disrupt the activity of the core planar polarity protein Dishevelled, with quantitative measurements of protein dynamics and levels, and mosaic analysis, to investigate Dishevelled function in maintenance of planar polarity. We provide mechanistic insight into the hierarchical relationship of Dishevelled with other members of the core planar polarity complex. Notably, we show that removal of Dishevelled in one cell causes rapid release of Prickle into the cytoplasm in the neighboring cell. This release of Prickle generates a self-propagating wave of planar polarity complex destabilization across the tissue. Thus, Dishevelled actively maintains complex integrity across intercellular junctions.
Pubmed ID: 30403998 RIS Download
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View all literature mentionsAn Antibody supplier and subset of ThermoFisher Scientific which provides fluorescence reagents for various experiments and methods.
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View all literature mentionsThis monoclonal targets HA
View all literature mentionsThis monoclonal targets Actin
View all literature mentionsThis monoclonal targets Flamingo (starry night)
View all literature mentionsDiscontinued
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}1, w[1118]; Adv[1]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1] dsh[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] shi[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] P{w[+mC]=Ubx-FLP}1 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}20; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=Act5C-GAL4}25FO1/CyO, y[+] from BDSC.
View all literature mentionsThis monoclonal targets Actin
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsDrosophila melanogaster with name w[1] dsh[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=Act5C-GAL4}25FO1/CyO, y[+] from BDSC.
View all literature mentionsDiscontinued
View all literature mentionsDrosophila melanogaster with name w[1118] shi[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] P{w[+mC]=Ubx-FLP}1 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}20; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsThis monoclonal targets HA
View all literature mentionsThis monoclonal targets Flamingo (starry night)
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}1, w[1118]; Adv[1]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] P{w[+mC]=Ubx-FLP}1 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}1, w[1118]; Adv[1]/CyO from BDSC.
View all literature mentionsDiscontinued
View all literature mentionsDrosophila melanogaster with name w[1118] shi[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1] dsh[1] from BDSC.
View all literature mentionsThis monoclonal targets Flamingo (starry night)
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}20; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=Act5C-GAL4}25FO1/CyO, y[+] from BDSC.
View all literature mentionsThis monoclonal targets HA
View all literature mentionsThis monoclonal targets Actin
View all literature mentionsThis polyclonal targets GFP
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