In mammals, neurons in the peripheral nervous system (PNS) have regenerative capacity following injury, but it is generally absent in the CNS. This difference is attributed, at least in part, to the intrinsic ability of PNS neurons to activate a unique regenerative transcriptional program following injury. Here, we profiled gene expression following sciatic nerve crush in mice and identified long noncoding RNAs (lncRNAs) that act in the regenerating neurons and which are typically not expressed in other contexts. We show that two of these lncRNAs regulate the extent of neuronal outgrowth. We then focus on one of these, Silc1, and show that it regulates neuroregeneration in cultured cells and in vivo, through cis-acting activation of the transcription factor Sox11.
Pubmed ID: 30401432 RIS Download
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View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsThis polyclonal targets Full-length recombinant denatured and non-denatured TagRFP comprising 6XHis tag
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View all literature mentionsThis polyclonal targets NEFH
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsCell line Neuro-2a is a Cancer cell line with a species of origin Mus musculus
View all literature mentionsCell line B16-F0 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line B16-F0 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line Neuro-2a is a Cancer cell line with a species of origin Mus musculus
View all literature mentionsThis polyclonal targets NEFH
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis unknown targets
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