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The mammalian imprinted Dlk1-Dio3 locus produces multiple long non-coding RNAs (lncRNAs) from the maternally inherited allele, including Meg3 (i.e., Gtl2) in the mammalian genome. Although this locus has well-characterized functions in stem cell and tumor contexts, its role during neural development is unknown. By profiling cell types at each stage of embryonic stem cell-derived motor neurons (ESC~MNs) that recapitulate spinal cord development, we uncovered that lncRNAs expressed from the Dlk1-Dio3 locus are predominantly and gradually enriched in rostral motor neurons (MNs). Mechanistically, Meg3 and other Dlk1-Dio3 locus-derived lncRNAs facilitate Ezh2/Jarid2 interactions. Loss of these lncRNAs compromises the H3K27me3 landscape, leading to aberrant expression of progenitor and caudal Hox genes in postmitotic MNs. Our data thus illustrate that these lncRNAs in the Dlk1-Dio3 locus, particularly Meg3, play a critical role in maintaining postmitotic MN cell fate by repressing progenitor genes and they shape MN subtype identity by regulating Hox genes.
Pubmed ID: 30311912 RIS Download
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Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsCommercial antibody vendor which supplies antibodies and other products to life science researchers.
View all literature mentionsA next-generation web-based application that aims to provide an integrated solution for both visualization and analysis of deep-sequencing data, along with simple access to public datasets.
View all literature mentionsHuman and mouse genome annotation project which aims to identify all gene features in the human genome using computational analysis, manual annotation, and experimental validation.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis polyclonal targets Pea3
View all literature mentionsThis unknown targets JARID2
View all literature mentionsThis polyclonal targets FOXP1
View all literature mentionsThis polyclonal targets SUZ12 - ChIP Grade
View all literature mentionsThis polyclonal targets Scip
View all literature mentionsThis monoclonal targets Islet-1 & Islet-2 homeobox
View all literature mentionsThis polyclonal targets HOXC8
View all literature mentionsThis monoclonal targets Histone H3 (tri methyl K27) antibody [mAbcam 6002] - ChIP Grade
View all literature mentionsThis polyclonal targets LHX3 antibody
View all literature mentionsThis monoclonal targets EZH2
View all literature mentionsThis unknown targets GREEN FLUORESCENT PROTEIN
View all literature mentionsThis polyclonal targets Oligodendrocute transcription factor 2
View all literature mentionsThis monoclonal targets MNR2/HB9/Mnx1
View all literature mentionsThis monoclonal targets Histone H3 antibody [mAbcam 24834]
View all literature mentionsThis monoclonal targets Nkx2.2 transcription factor
View all literature mentionsThis monoclonal targets Homeobox C8
View all literature mentionsThis polyclonal targets Pax-6
View all literature mentionsThis polyclonal targets chicken HoxC9, cross reacts with mouse HoxC9
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsThis monoclonal targets Nkx2.2 transcription factor
View all literature mentionsThis monoclonal targets Nkx2.2 transcription factor
View all literature mentionsThis monoclonal targets Histone H3 antibody [mAbcam 24834]
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsThis monoclonal targets Histone H3 (tri methyl K27) antibody [mAbcam 6002] - ChIP Grade
View all literature mentionsThis polyclonal targets chicken HoxC9, cross reacts with mouse HoxC9
View all literature mentionsThis polyclonal targets Oligodendrocute transcription factor 2
View all literature mentionsThis monoclonal targets Nkx2.2 transcription factor
View all literature mentionsThis monoclonal targets MNR2/HB9/Mnx1
View all literature mentionsThis monoclonal targets Homeobox C8
View all literature mentionsThis monoclonal targets Islet-1 & Islet-2 homeobox
View all literature mentionsThis polyclonal targets FOXP1
View all literature mentionsThis polyclonal targets Pax-6
View all literature mentionsThis unknown targets GREEN FLUORESCENT PROTEIN
View all literature mentionsThis polyclonal targets Scip
View all literature mentionsThis polyclonal targets Pea3
View all literature mentionsThis polyclonal targets HOXC8
View all literature mentionsThis polyclonal targets LHX3 antibody
View all literature mentionsThis polyclonal targets SUZ12 - ChIP Grade
View all literature mentionsThis unknown targets JARID2
View all literature mentionsThis monoclonal targets EZH2
View all literature mentionsThis polyclonal targets Pea3
View all literature mentionsThis polyclonal targets LHX3 antibody
View all literature mentionsThis polyclonal targets FOXP1
View all literature mentionsThis monoclonal targets MNR2/HB9/Mnx1
View all literature mentionsThis unknown targets GREEN FLUORESCENT PROTEIN
View all literature mentionsThis polyclonal targets Pax-6
View all literature mentionsThis polyclonal targets Scip
View all literature mentionsThis polyclonal targets HOXC8
View all literature mentionsThis monoclonal targets Islet-1 & Islet-2 homeobox
View all literature mentionsThis monoclonal targets Homeobox C8
View all literature mentionsThis monoclonal targets Histone H3 (tri methyl K27) antibody [mAbcam 6002] - ChIP Grade
View all literature mentionsThis polyclonal targets SUZ12 - ChIP Grade
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsThis polyclonal targets chicken HoxC9, cross reacts with mouse HoxC9
View all literature mentionsThis monoclonal targets EZH2
View all literature mentionsThis polyclonal targets Oligodendrocute transcription factor 2
View all literature mentionsThis unknown targets JARID2
View all literature mentionsThis monoclonal targets Histone H3 antibody [mAbcam 24834]
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