Although chronic gastrointestinal dysmotility syndromes are a common worldwide health problem, underlying causes for these disorders are poorly understood. We show that flavivirus infection of enteric neurons leads to acute neuronal injury and cell death, inflammation, bowel dilation, and slowing of intestinal transit in mice. Flavivirus-primed CD8+ T cells promote these phenotypes, as their absence diminished enteric neuron injury and intestinal transit delays, and their adoptive transfer reestablished dysmotility after flavivirus infection. Remarkably, mice surviving acute flavivirus infection developed chronic gastrointestinal dysmotility that was exacerbated by immunization with an unrelated alphavirus vaccine or exposure to a non-infectious inflammatory stimulus. This model of chronic post-infectious gastrointestinal dysmotility in mice suggests that viral infections with tropism for enteric neurons and the ensuing immune response might contribute to the development of bowel motility disorders in humans. These results suggest an opportunity for unique approaches to diagnosis and therapy of gastrointestinal dysmotility syndromes.
Pubmed ID: 30293866 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Commercial supplier and developer of in vivo antibodies. Provides antibodies and antibody production services.
View all literature mentionsThis monoclonal targets CD16/32
View all literature mentionsThis monoclonal targets CD64
View all literature mentionsThis monoclonal targets CX3CR1
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets I-A/I-E
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis isotype control targets Unknown Specificify
View all literature mentionsThis monoclonal targets IFNAR1
View all literature mentionsThis polyclonal targets Cleaved Caspase-3 (Asp175)
View all literature mentionsThis polyclonal targets CD3
View all literature mentionsThis unknown targets Human /MousePHOX2B Affinity Purified Ab
View all literature mentionsThis polyclonal targets Mouse GFAP
View all literature mentionsThis polyclonal targets beta-Tubulin III antibody produced in rabbit
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsMus musculus with name B6.129S2-Cd8atm1Mak/J from IMSR.
View all literature mentions
Mus musculus with name B6.129P2-Tcrbtm1Mom Tcrd
Mus musculus with name B6.129S7-Rag1tm1Mom/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsCell line BHK-21 clone 13 is a Spontaneously immortalized cell line with a species of origin Mesocricetus auratus
View all literature mentions