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Natural killer (NK) cells are innate lymphocytes that possess adaptive features, including antigen-specific clonal expansion and long-lived memory responses. Although previous work demonstrated that type I interferon (IFN) signaling is crucial for NK cell expansion and memory cell formation following mouse cytomegalovirus (MCMV) infection, the global transcriptional mechanisms underlying type I IFN-mediated responses remained to be determined. Here, we demonstrate that among the suite of transcripts induced in activated NK cells, IFN-α is necessary and sufficient to promote expression of its downstream transcription factors STAT1, STAT2, and IRF9, via an auto-regulatory, feedforward loop. Similar to STAT1 deficiency, we show that STAT2- or IRF9-deficient NK cells are defective in their ability to expand following MCMV infection, in part because of diminished survival rather than an inability to proliferate. Thus, our findings demonstrate that individual ISGF3 components are crucial cell-autonomous and non-redundant regulators of the NK cell response to viral infection.
Pubmed ID: 30134157 RIS Download
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A powerful toolset for genome arithmetic allowing one to address common genomics tasks such as finding feature overlaps and computing coverage. Bedtools allows one to intersect, merge, count, complement, and shuffle genomic intervals from multiple files in widely-used genomic file formats such as BAM, BED, GFF/GTF, VCF. While each individual tool is designed to do a relatively simple task (e.g., intersect two interval files), quite sophisticated analyses can be conducted by combining multiple bedtools operations on the UNIX command line.
View all literature mentionsUltrafast and memory efficient tool for aligning sequencing reads to long reference sequences. Supports gapped, local, and paired end alignment modes. More suited to finding longer, gapped alignments in comparison with original Bowtie method.
View all literature mentionsSoftware ultrafast memory efficient tool for aligning sequencing reads. Bowtie is short read aligner.
View all literature mentionsThis polyclonal targets STAT1
View all literature mentionsThis polyclonal targets IRF9
View all literature mentionsThis monoclonal targets Ter-119
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD8α
View all literature mentionsThis monoclonal targets CD107a
View all literature mentionsThis monoclonal targets IFN gamma
View all literature mentionsThis monoclonal targets Granzyme B
View all literature mentionsThis monoclonal targets CD69
View all literature mentionsThis monoclonal targets Ly-49C, Ly-49I
View all literature mentionsThis monoclonal targets Ly-49A
View all literature mentionsThis monoclonal targets Ly49D
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets CD27
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD49b
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets Mouse Ly-49H (Ly49H)
View all literature mentionsThis monoclonal targets CD335
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets TCR beta chain
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsMus musculus with name B6.129-Stat2tm1Shnd/J from IMSR.
View all literature mentions
Mus musculus with name C;129S4-Rag2tm1.1Flv Il2rg
Mus musculus with name B6(Cg)-Ifnar1tm1.2Ees/J from IMSR.
View all literature mentionsMus musculus with name B6.129P2-Gt(ROSA)26Sortm1(DTA)Lky/J from IMSR.
View all literature mentions
Mus musculus with name B6.SJL-Ptprca Pepc
Mus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name B6.129-Stat2tm1Shnd/J from IMSR.
View all literature mentions
Mus musculus with name C;129S4-Rag2tm1.1Flv Il2rg
Mus musculus with name B6(Cg)-Ifnar1tm1.2Ees/J from IMSR.
View all literature mentionsMus musculus with name B6.129P2-Gt(ROSA)26Sortm1(DTA)Lky/J from IMSR.
View all literature mentions
Mus musculus with name B6.SJL-Ptprca Pepc
Mus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis polyclonal targets STAT1
View all literature mentionsThis polyclonal targets IRF9
View all literature mentionsThis monoclonal targets Ter-119
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD8α
View all literature mentionsThis monoclonal targets CD107a
View all literature mentionsThis monoclonal targets IFN gamma
View all literature mentionsThis monoclonal targets Granzyme B
View all literature mentionsThis monoclonal targets CD69
View all literature mentionsThis monoclonal targets Ly-49C, Ly-49I
View all literature mentionsThis monoclonal targets Ly-49A
View all literature mentionsThis monoclonal targets Ly49D
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets CD27
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD49b
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets Mouse Ly-49H (Ly49H)
View all literature mentionsThis monoclonal targets CD335
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets TCR beta chain
View all literature mentionsThis monoclonal targets CD3
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