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KIF1Bβ is a kinesin-3 family anterograde motor protein essential for neuronal development, viability, and function. KIF1Bβ mutations have previously been reported in a limited number of pedigrees of Charcot-Marie-Tooth disease type 2A (CMT2A) neuropathy. However, the gene responsible for CMT2A is still controversial, and the mechanism of pathogenesis remains elusive. In this study, we show that the receptor tyrosine kinase IGF1R is a new direct binding partner of KIF1Bβ, and its binding and transport is specifically impaired by the Y1087C mutation of KIF1Bβ, which we detected in hereditary neuropathic patients. The axonal outgrowth and IGF-I signaling of Kif1b-/- neurons were significantly impaired, consistent with decreased surface IGF1R expression. The complementary capacity of KIF1Bβ-Y1087C of these phenotypes was significantly impaired, but the binding capacity to synaptic vesicle precursors was not affected. These data have supported the relevance of KIF1Bβ in IGF1R transport, which may give new clue to the neuropathic pathogenesis.
Pubmed ID: 30126838 RIS Download
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Software tool for automated microscope acquisition, device control, and image analysis. Used for integrating dissimilar fluorescent microscope hardware and peripherals into a single custom workstation, while providing all the tools needed to perform analysis of acquired images. Offers user friendly application modules for analysis such as cell signaling, cell counting, and protein expression.
View all literature mentionsCollection of curated, non-redundant genomic DNA, transcript RNA, and protein sequences produced by NCBI. Provides a reference for genome annotation, gene identification and characterization, mutation and polymorphism analysis, expression studies, and comparative analyses. Accessed through the Nucleotide and Protein databases.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
View all literature mentionsAntibody and density gradient media supplier.
View all literature mentionslaboratory mouse with name C57BL/6N from MGI.
View all literature mentionsCell line HEK293-A is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis polyclonal targets KIF1Balpha
View all literature mentionsThis polyclonal targets KIF1Bbeta
View all literature mentionsThis monoclonal targets slightly modified β-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH
View all literature mentionsThis polyclonal targets Erk1/2
View all literature mentionsThis monoclonal targets
View all literature mentionsThis monoclonal targets anti-DDDDK-tag
View all literature mentionsThis monoclonal targets Synaptophysin
View all literature mentionsThis monoclonal targets
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets α-Tubulin
View all literature mentionsThis monoclonal targets beta-Tubulin Isotype III antibody produced in mouse
View all literature mentionsThis polyclonal targets Igf1r
View all literature mentionsThis monoclonal targets IGF-IRalpha (G-5)
View all literature mentionsThis polyclonal targets KIF1Balpha
View all literature mentionsThis polyclonal targets KIF1Bbeta
View all literature mentionsThis monoclonal targets slightly modified β-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH
View all literature mentionsThis polyclonal targets Erk1/2
View all literature mentionsThis monoclonal targets
View all literature mentionsThis monoclonal targets anti-DDDDK-tag
View all literature mentionsThis monoclonal targets Synaptophysin
View all literature mentionsThis monoclonal targets
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets α-Tubulin
View all literature mentionsThis monoclonal targets beta-Tubulin Isotype III antibody produced in mouse
View all literature mentionsThis polyclonal targets Igf1r
View all literature mentionsThis monoclonal targets IGF-IRalpha (G-5)
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