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We generated a knockout mouse for the neuronal-specific β-tubulin isoform Tubb3 to investigate its role in nervous system formation and maintenance. Tubb3-/- mice have no detectable neurobehavioral or neuropathological deficits, and upregulation of mRNA and protein of the remaining β-tubulin isotypes results in equivalent total β-tubulin levels in Tubb3-/- and wild-type mice. Despite similar levels of total β-tubulin, adult dorsal root ganglia lacking TUBB3 have decreased growth cone microtubule dynamics and a decreased neurite outgrowth rate of 22% in vitro and in vivo. The effect of the 22% slower growth rate is exacerbated for sensory recovery, where fibers must reinnervate the full volume of the skin to recover touch function. Overall, these data reveal that, while TUBB3 is not required for formation of the nervous system, it has a specific role in the rate of peripheral axon regeneration that cannot be replaced by other β-tubulins.
Pubmed ID: 30110642 RIS Download
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This monoclonal targets Kinesin, Heavy Chain
View all literature mentionsThis unknown targets Tubulin, delta 2
View all literature mentionsThis polyclonal targets Neurofilament, Heavy
View all literature mentionsThis unknown targets Chicken IgY (IgG) (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets GAPDH
View all literature mentionsThis unknown targets Tubulin, Detyrosinated
View all literature mentionsThis monoclonal targets Tubulin
View all literature mentionsThis monoclonal targets derived from the hybridoma 6-11B-1 produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with acetylated tubulin from the outer arm of Strongylocentrotus purpuratus (sea urchin).
View all literature mentionsThis monoclonal targets Tubulin, beta
View all literature mentionsThis monoclonal targets Dynein 74 kDa Intermediate chains cytoplasmic clone 74.1
View all literature mentionsThis polyclonal targets beta III Tubulin
View all literature mentionsThis monoclonal targets alpha-Tubulin
View all literature mentionsThis polyclonal secondary targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis monoclonal targets neurofilament (NF-M)
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name 129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(Isl1-EGFP*)1Slp/J from IMSR.
View all literature mentionsMus musculus with name 129S6/SvEvTac from IMSR.
View all literature mentionsMus musculus with name B6.FVB-Tg(EIIa-cre)C5379Lmgd/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc17a6tm2(cre)Lowl/J from IMSR.
View all literature mentionsMus musculus with name B6.FVB-Tg(EIIa-cre)C5379Lmgd/J from IMSR.
View all literature mentionsMus musculus with name 129S1/SvImJ from IMSR.
View all literature mentionsThis unknown targets Chicken IgY (IgG) (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets GAPDH
View all literature mentionsThis monoclonal targets Tubulin
View all literature mentionsThis monoclonal targets derived from the hybridoma 6-11B-1 produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with acetylated tubulin from the outer arm of Strongylocentrotus purpuratus (sea urchin).
View all literature mentionsThis monoclonal targets Tubulin, beta
View all literature mentionsThis monoclonal targets Dynein 74 kDa Intermediate chains cytoplasmic clone 74.1
View all literature mentionsThis polyclonal targets beta III Tubulin
View all literature mentionsThis monoclonal targets alpha-Tubulin
View all literature mentionsThis polyclonal secondary targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis monoclonal targets neurofilament (NF-M)
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Neurofilament, Heavy
View all literature mentionsThis unknown targets Tubulin, delta 2
View all literature mentionsThis unknown targets Tubulin, Detyrosinated
View all literature mentionsThis monoclonal targets Kinesin, Heavy Chain
View all literature mentionsThis monoclonal targets Kinesin, Heavy Chain
View all literature mentionsMus musculus with name STOCK Tg(Isl1-EGFP*)1Slp/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc17a6tm2(cre)Lowl/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name 129S1/SvImJ from IMSR.
View all literature mentionsMus musculus with name 129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(Isl1-EGFP*)1Slp/J from IMSR.
View all literature mentionsThis unknown targets Tubulin, delta 2
View all literature mentionsThis unknown targets Tubulin, Detyrosinated
View all literature mentionsThis unknown targets Tubulin, delta 2
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name 129S1/SvImJ from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name 129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc17a6tm2(cre)Lowl/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(Isl1-EGFP*)1Slp/J from IMSR.
View all literature mentionsMus musculus with name 129S4/SvJaeSor-Gt(ROSA)26Sortm1(FLP1)Dym/J from IMSR.
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