Searching across hundreds of databases
Heterogeneity between different macrophage populations has become a defining feature of this lineage. However, the conserved factors defining macrophages remain largely unknown. The transcription factor ZEB2 is best described for its role in epithelial to mesenchymal transition; however, its role within the immune system is only now being elucidated. We show here that Zeb2 expression is a conserved feature of macrophages. Using Clec4f-cre, Itgax-cre, and Fcgr1-cre mice to target five different macrophage populations, we found that loss of ZEB2 resulted in macrophage disappearance from the tissues, coupled with their subsequent replenishment from bone-marrow precursors in open niches. Mechanistically, we found that ZEB2 functioned to maintain the tissue-specific identities of macrophages. In Kupffer cells, ZEB2 achieved this by regulating expression of the transcription factor LXRα, removal of which recapitulated the loss of Kupffer cell identity and disappearance. Thus, ZEB2 expression is required in macrophages to preserve their tissue-specific identities.
Pubmed ID: 30076102 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
A commercial organization which provides assay technologies to isolate DNA, RNA, and proteins from any biological sample. Assay technologies are then used to make specific target biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.
View all literature mentionsA next-generation web-based application that aims to provide an integrated solution for both visualization and analysis of deep-sequencing data, along with simple access to public datasets.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsSoftware package for the analysis of gene expression microarray data, especially the use of linear models for analyzing designed experiments and the assessment of differential expression.
View all literature mentionsSoftware Java pipeline for trimming tasks for Illumina paired end and single ended data. Flexible Trimmer for Illumina Sequence Data. Pair aware preprocessing tool optimized for Illumina next generation sequencing data. Includes several processing steps for read trimming and filtering. Operating systems Unix/Linux, Mac OS, Windows.
View all literature mentionsQuality control software that perform checks on raw sequence data coming from high throughput sequencing pipelines. This software also provides a modular set of analyses which can give a quick impression of the quality of the data prior to further analysis.
View all literature mentionsSoftware toolkit for doing various analyses of single-cell RNA-seq gene expression data, with a focus on quality control. This package facilitates pre-processing, quality control, normalization and visualization of scRNA-seq data.
View all literature mentionslaboratory mouse with name C57BL/6N from MGI.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentions
Mus musculus with name B6.SJL-Ptprca Pepc
This unknown targets
View all literature mentionsThis monoclonal targets CD55
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets Mouse F4/80 ANTIGEN
View all literature mentionsThis polyclonal targets RFP
View all literature mentionsThis monoclonal targets CD326
View all literature mentionsThis monoclonal targets CD101
View all literature mentionsThis monoclonal targets CD20
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets TIM-4
View all literature mentionsThis monoclonal targets Tim-4
View all literature mentionsThis monoclonal targets TIM-4
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD26
View all literature mentionsThis monoclonal targets Mouse Ly-6G
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Siglec-F
View all literature mentionsThis monoclonal targets Siglec-F
View all literature mentionsThis polyclonal targets Mouse CLECSF13 / CLEC4F
View all literature mentionsThis monoclonal targets CD11b (Mac-1)
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD64
View all literature mentionsThis monoclonal targets CD55
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets Mouse F4/80 ANTIGEN
View all literature mentionsThis polyclonal targets RFP
View all literature mentionsThis monoclonal targets CD326
View all literature mentionsThis monoclonal targets CD101
View all literature mentionsThis monoclonal targets CD20
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets TIM-4
View all literature mentionsThis monoclonal targets Tim-4
View all literature mentionsThis monoclonal targets TIM-4
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD26
View all literature mentionsThis monoclonal targets Mouse Ly-6G
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Siglec-F
View all literature mentionsThis monoclonal targets Siglec-F
View all literature mentionsThis polyclonal targets Mouse CLECSF13 / CLEC4F
View all literature mentionsThis monoclonal targets CD11b (Mac-1)
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD64
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
