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In response to environmental, developmental, and pathological stressors, cells engage homeostatic pathways to maintain their function. Among these pathways, the Unfolded Protein Response protects cells from the accumulation of misfolded proteins in the ER. Depending on ER stress levels, the ER-resident Fic protein catalyzes AMPylation or de-AMPylation of BiP, the major ER chaperone and regulator of the Unfolded Protein Response. This work elucidates the importance of the reversible AMPylation of BiP in maintaining the Drosophila visual system in response to stress. After 72 hr of constant light, photoreceptors of fic-null and AMPylation-resistant BiPT366A mutants, but not wild-type flies, display loss of synaptic function, disintegration of rhabdomeres, and excessive activation of ER stress reporters. Strikingly, this phenotype is reversible: photoreceptors regain their structure and function within 72 hr once returned to a standard light:dark cycle. These findings show that Fic-mediated AMPylation of BiP is required for neurons to adapt to transient stress demands.
Pubmed ID: 30015618 RIS Download
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An Antibody supplier and subset of ThermoFisher Scientific which provides fluorescence reagents for various experiments and methods.
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View all literature mentionsWe provide high quality Drosophila transgenic service to both research institutions and companies. We offer you partial to full service ranging from DNA preparation, embryo microinjection, screening for white+, yellow+, and/or GFP/RFP phenotypes, to balancing crosses. Most importantly, the cost of our Drosophila embryo injection services is more reasonable compared to that of others. With a large number of facilities and the highly experienced staff, we are able to initiate the process immediately upon receiving your sample. Our friendly web-based database allows you to track your sample status, service history and more.
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View all literature mentionsCollects, maintains and distributes Drosophila melanogaster strains for research. Emphasis is placed on genetic tools that are useful to a broad range of investigations. These include basic stocks of flies used in genetic analysis such as marker, balancer, mapping, and transposon-tagging strains; mutant alleles of identified genes, including a large set of transposable element insertion alleles; defined sets of deficiencies and a variety of other chromosomal aberrations; engineered lines for somatic and germline clonal analysis; GAL4 and UAS lines for targeted gene expression; enhancer trap and lacZ-reporter strains with defined expression patterns for marking tissues; and a collection of transposon-induced lethal mutations.
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View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Xbp1.EGFP.HG}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[67c23] P{w[+mC]=lacW}Hsc70-3[G0102]/FM7c from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; wg[Sp-1]/CyO; P{w[+mC]=longGMR-GAL4}3/TM2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mW.hs]=GAL4-da.G32}UH1, Sb[1]/TM6B, Tb[1] from BDSC.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Xbp1.EGFP.HG}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[67c23] P{w[+mC]=lacW}Hsc70-3[G0102]/FM7c from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; wg[Sp-1]/CyO; P{w[+mC]=longGMR-GAL4}3/TM2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mW.hs]=GAL4-da.G32}UH1, Sb[1]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[67c23] P{w[+mC]=lacW}Hsc70-3[G0102]/FM7c from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; wg[Sp-1]/CyO; P{w[+mC]=longGMR-GAL4}3/TM2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mW.hs]=GAL4-da.G32}UH1, Sb[1]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Xbp1.EGFP.HG}3 from BDSC.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsThis monoclonal targets Actin
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis unknown targets GFP
View all literature mentionsThis polyclonal targets RFP
View all literature mentionsThis polyclonal targets Hsc70-3
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Xbp1.EGFP.HG}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[67c23] P{w[+mC]=lacW}Hsc70-3[G0102]/FM7c from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; wg[Sp-1]/CyO; P{w[+mC]=longGMR-GAL4}3/TM2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mW.hs]=GAL4-da.G32}UH1, Sb[1]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Xbp1.EGFP.HG}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[67c23] P{w[+mC]=lacW}Hsc70-3[G0102]/FM7c from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; wg[Sp-1]/CyO; P{w[+mC]=longGMR-GAL4}3/TM2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mW.hs]=GAL4-da.G32}UH1, Sb[1]/TM6B, Tb[1] from BDSC.
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