Searching across hundreds of databases
Dietary fiber protects against chronic inflammatory diseases by dampening immune responses through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in viral infection, where the anti-inflammatory properties of SCFAs in principle could prevent protective immunity. Instead, we found that fermentable dietary fiber increased survival of influenza-infected mice through two complementary mechanisms. High-fiber diet (HFD)-fed mice exhibited altered bone marrow hematopoiesis, characterized by enhanced generation of Ly6c- patrolling monocytes, which led to increased numbers of alternatively activated macrophages with a limited capacity to produce the chemokine CXCL1 in the airways. Blunted CXCL1 production reduced neutrophil recruitment to the airways, thus limiting tissue immunopathology during infection. In parallel, diet-derived SCFAs boosted CD8+ T cell effector function by enhancing cellular metabolism. Hence, dietary fermentable fiber and SCFAs set an immune equilibrium, balancing innate and adaptive immunity so as to promote the resolution of influenza infection while preventing immune-associated pathology.
Pubmed ID: 29768180 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Software environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
View all literature mentionsThis monoclonal targets CD28
View all literature mentionsThis monoclonal targets CD3ε
View all literature mentionsThis monoclonal targets Pacific Blue anti-mouse Lineage Cocktail
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD135
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis monoclonal targets CD16/32
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets Ly-6A/E
View all literature mentionsThis monoclonal targets TNF-alpha
View all literature mentionsThis monoclonal targets IFN-gamma
View all literature mentionsThis monoclonal targets Granzyme B
View all literature mentionsThis monoclonal targets CD107a
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis polyclonal targets Rabbit IgG
View all literature mentionsThis monoclonal targets CD86
View all literature mentionsThis monoclonal targets CD273
View all literature mentionsThis monoclonal targets CD206
View all literature mentionsThis monoclonal targets CD70
View all literature mentionsThis monoclonal targets CD40
View all literature mentionsThis monoclonal targets CX3CR1
View all literature mentionsThis monoclonal targets CD192
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets I-A/I-E
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis isotype control targets Trinitrophenol
View all literature mentionsThis monoclonal targets Ly6G
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
