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Publication

Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation.

Alice Valentin-Torres | Carine Savarin | Joslyn Barnett | Cornelia C Bergmann

Journal of neuroinflammation | 2018

Tumor necrosis factor (TNF) is associated with several neurodegenerative disorders including multiple sclerosis (MS). Although TNF-targeted therapies have been largely unsuccessful in MS, recent preclinical data suggests selective soluble TNF inhibition can promote remyelination. This has renewed interest in regulation of TNF signaling in demyelinating disease, especially given the limited treatment options for progressive MS. Using a mouse model of progressive MS, this study evaluates the effects of sustained TNF on oligodendrocyte (OLG) apoptosis and OLG precursor cell (OPC) differentiation.

Pubmed ID: 29690885 RIS Download

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Associated grants

Agency: NCI NIH HHS, United States
Id: P30 CA014089
Agency: NCRR NIH HHS, United States
Id: S10 RR026820

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FlowJo (tool)

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Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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