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Publication

Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets.

Cell metabolism | 2018

Visceral adipose tissue (VAT) has multiple roles in orchestrating whole-body energy homeostasis. In addition, VAT is now considered an immune site harboring an array of innate and adaptive immune cells with a direct role in immune surveillance and host defense. We report that conventional dendritic cells (cDCs) in VAT acquire a tolerogenic phenotype through upregulation of pathways involved in adipocyte differentiation. While activation of the Wnt/β-catenin pathway in cDC1 DCs induces IL-10 production, upregulation of the PPARγ pathway in cDC2 DCs directly suppresses their activation. Combined, they promote an anti-inflammatory milieu in vivo delaying the onset of obesity-induced chronic inflammation and insulin resistance. Under long-term over-nutrition, changes in adipocyte biology curtail β-catenin and PPARγ activation, contributing to VAT inflammation.

Pubmed ID: 29514067 RIS Download

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Associated grants

Agency: British Heart Foundation, United Kingdom
Id: RG/14/2/30616
Agency: Medical Research Council, United Kingdom
Id: MR/L002345/2
Agency: British Heart Foundation, United Kingdom
Id: PG/16/79/32419
Agency: Medical Research Council, United Kingdom
Id: MR/L002345/1
Agency: British Heart Foundation, United Kingdom
Id: FS/14/66/31293
Agency: British Heart Foundation, United Kingdom
Id: FS/13/49/30421

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