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Publication

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.

Cell | 2018

CNS injury often severs axons. Scar tissue that forms locally at the lesion site is thought to block axonal regeneration, resulting in permanent functional deficits. We report that inhibiting the generation of progeny by a subclass of pericytes led to decreased fibrosis and extracellular matrix deposition after spinal cord injury in mice. Regeneration of raphespinal and corticospinal tract axons was enhanced and sensorimotor function recovery improved following spinal cord injury in animals with attenuated pericyte-derived scarring. Using optogenetic stimulation, we demonstrate that regenerated corticospinal tract axons integrated into the local spinal cord circuitry below the lesion site. The number of regenerated axons correlated with improved sensorimotor function recovery. In conclusion, attenuation of pericyte-derived fibrosis represents a promising therapeutic approach to facilitate recovery following CNS injury.

Pubmed ID: 29502968 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

Antibodies used in this publication

Associated grants

None

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This is a list of tools and resources that we have found mentioned in this publication.

Jackson Laboratory (tool)

RRID:SCR_004633

An independent, nonprofit organization focused on mammalian genetics research to advance human health. Their mission is to discover the genetic basis for preventing, treating, and curing human disease, and to enable research for the global biomedical community. Jackson Laboratory breeds and manages colonies of mice as resources for other research institutions and laboratories, along with providing software and techniques. Jackson Lab also conducts genetic research and provides educational material for various educational levels.

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QIAGEN (tool)

RRID:SCR_008539

A commercial organization which provides assay technologies to isolate DNA, RNA, and proteins from any biological sample. Assay technologies are then used to make specific target biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.

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Ingenuity Pathways Knowledge Base (tool)

RRID:SCR_008117

A horizontally and vertically structured database that pulls scientific and medical information and describes it consistently using the Ingenuity Ontology. The Knowledge Base pulls information from journals, public molecular content databases, and textbooks. Data is curated and and integrated into the Knowledge Base .

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BD Biosciences (tool)

RRID:SCR_013311

An Antibody supplier

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Synaptic Systems (tool)

RRID:SCR_013612

An Antibody supplier

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PRISM (tool)

RRID:SCR_005375

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.

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Adobe Illustrator (tool)

RRID:SCR_010279

Vector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.

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Agilent Technologies (tool)

RRID:SCR_013575

Company provides laboratories worldwide with analytical instruments and supplies, clinical and diagnostic testing services, consumables, applications and expertise in life sciences and applied chemical markets.

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Adobe Photoshop (tool)

RRID:SCR_014199

Software for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Rat IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Shp Sr Prot) (antibody)

RRID:AB_2340669

This unknown targets Rat IgG (H+L)

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Rabbit Anti-Collagen VI Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_305585

This polyclonal targets Collagen VI

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Goat Anti-GFP (Green Fluorescent Protein) Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_305643

This polyclonal targets GFP

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S100 (antibody)

RRID:AB_10013383

This polyclonal targets S100 isolated from cow brain.

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Myelin Protein Zero antibody (antibody)

RRID:AB_2144668

This polyclonal targets Mpz

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Ctip2 antibody [25B6] - ChIP Grade (antibody)

RRID:AB_2064130

This monoclonal targets Ctip2

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Peroxidase-AffiniPure F(ab')2 Fragment Donkey Anti-Goat IgG (H+L) (min X Ck,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat Sr Prot) (antibody)

RRID:AB_2340392

This unknown targets Goat IgG (H+L)

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Peroxidase-AffiniPure F(ab')2 Fragment Donkey Anti-Rabbit IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340590

This unknown targets Rabbit IgG (H+L)

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Peroxidase-AffiniPure F(ab')2 Fragment Donkey Anti-Mouse IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340774

This unknown targets Mouse IgG (H+L)

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S100A4 antibody (antibody)

RRID:AB_2183775

This polyclonal targets S100A4 antibody

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Rabbit Anti-Periostin Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_2299859

This polyclonal targets Periostin

View all literature mentions

PDGF Receptor beta (28E1) Rabbit mAb (antibody)

RRID:AB_2162497

This recombinant monoclonal targets PDGFRB

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PDIA2 polyclonal antibody (antibody)

RRID:AB_10556016

This polyclonal targets PDIA2 polyclonal antibody

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anti SERPINH1 / HSP47 (antibody)

RRID:AB_1954041

This unknown targets anti SERPINH1 / HSP47

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Anti-Glyceraldehyde-3-Phosphate Dehydrogenase Antibody, clone 6C5 (antibody)

RRID:AB_2107445

This monoclonal targets Glyceraldehyde-3-PDH (GAPDH)

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Alexa Fluor 647-AffiniPure F(ab')2 Fragment Donkey Anti-Guinea Pig IgG (H+L) (min X Bov,Ck,Gt,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340477

This unknown targets Guinea Pig IgG (H+L)

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Guinea Pig IgG (H+L) (min X Bov,Ck,Gt,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340461

This unknown targets Guinea Pig IgG (H+L)

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Alexa Fluor 488-AffiniPure F(ab')2 Fragment Donkey Anti-Guinea Pig IgG (H+L) (min X Bov,Ck,Gt,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340473

This unknown targets Guinea Pig IgG (H+L)

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DyLight 405-AffiniPure F(ab')2 Fragment Donkey Anti-Guinea Pig IgG (H+L) (min X Bov,Ck,Gt,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2632564

This unknown targets

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Alexa Fluor 488-AffiniPure F(ab')2 Fragment Donkey Anti-Rat IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Shp Sr Prot) (antibody)

RRID:AB_2340686

This unknown targets Rat IgG (H+L)

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Alexa Fluor 647-AffiniPure F(ab')2 Fragment Donkey Anti-Chicken IgY (IgG) (H+L) (min X Bov,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340380

This unknown targets Chicken IgY (IgG) (H+L)

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Chicken IgY (IgG) (H+L) (min X Bov,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340364

This unknown targets Chicken IgY (IgG) (H+L)

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Alexa Fluor 488-AffiniPure F(ab')2 Fragment Donkey Anti-Chicken IgY (IgG) (H+L) (min X Bov,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340376

This unknown targets Chicken IgY (IgG) (H+L)

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DyLight 405-AffiniPure F(ab')2 Fragment Donkey Anti-Chicken IgY (IgG) (H+L) (min X Bov,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2632562

This unknown targets

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Alexa Fluor 647-AffiniPure F(ab')2 Fragment Donkey Anti-Goat IgG (H+L) (min X Ck,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat Sr Prot) (antibody)

RRID:AB_2340438

This unknown targets Goat IgG (H+L)

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Goat IgG (H+L) (min X Ck,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat Sr Prot) (antibody)

RRID:AB_2340413

This unknown targets Goat IgG (H+L)

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Alexa Fluor 488-AffiniPure F(ab')2 Fragment Donkey Anti-Goat IgG (H+L) (min X Ck,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat Sr Prot) (antibody)

RRID:AB_2340430

This unknown targets Goat IgG (H+L)

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Alexa Fluor 647 AffiniPure F(ab')₂ Fragment Donkey Anti-Rabbit IgG (H+L) (antibody)

RRID:AB_2340625

This polyclonal targets IgG (H+L)

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Cy3-AffiniPure Donkey Anti-Rabbit IgG (H+L) (antibody)

RRID:AB_2313568

This polyclonal targets

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Alexa Fluor® 488 AffiniPure F(ab')₂ Fragment Donkey Anti-Rabbit IgG (H+L) (antibody)

RRID:AB_2340619

This polyclonal secondary targets IgG (H+L)

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DyLight 405-AffiniPure F(ab')2 Fragment Donkey Anti-Rabbit IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rat,Shp Sr Prot) (antibody)

RRID:AB_2632566

This unknown targets

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Alexa Fluor 647-AffiniPure F(ab')2 Fragment Donkey Anti-Mouse IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340866

This unknown targets Mouse IgG (H+L)

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Mouse IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340817

This unknown targets Mouse IgG (H+L)

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Alexa Fluor 488 donkey anti-mouse (antibody)

RRID:AB_2340850

This polyclonal targets

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Alexa Fluor 647-AffiniPure F(ab')2 Fragment Donkey Anti-Rat IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Shp Sr Prot) (antibody)

RRID:AB_2340696

This unknown targets Rat IgG (H+L)

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Alexa Fluor 594-AffiniPure F(ab')2 Fragment Donkey Anti-Rat IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Shp Sr Prot) (antibody)

RRID:AB_2340691

This unknown targets Rat IgG (H+L)

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Biotin-SP-AffiniPure F(ab')2 Fragment Donkey Anti-Rabbit IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340594

This unknown targets Rabbit IgG (H+L)

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Biotin-SP-AffiniPure F(ab')2 Fragment Donkey Anti-Mouse IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340788

This unknown targets Mouse IgG (H+L)

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NOT AN ANTIBODY Alexa Fluor 594-Streptavidin (antibody)

RRID:AB_2337250

This unknown targets Biotin

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Cy3-Streptavidin antibody (antibody)

RRID:AB_2337244

This polyclonal targets Cy3-Streptavidin

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PGP9.5 antibody - Neuronal Marker (antibody)

RRID:AB_297150

This polyclonal targets PGP9.5 - Neuronal Marker

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Rabbit Anti-PGP9.5 Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_297145

This polyclonal targets PGP9.5 - Neuronal Marker

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Synaptophysin antibody [SY38] (antibody)

RRID:AB_2198854

This monoclonal targets Syp

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Rabbit Anti-Synapsin I Polyclonal antibody, Unconjugated (antibody)

RRID:AB_90757

This polyclonal targets Synapsin I

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Anti-Synapsin 1 (antibody)

RRID:AB_2619772

This monoclonal targets Synapsin 1

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Mouse Podocalyxin Affinity Purified Polyclonal Ab (antibody)

RRID:AB_354858

This polyclonal targets Mouse Podocalyxin Affinity Purified Ab

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Recombinant Anti-PDGFR beta antibody [Y92] - C-terminal (antibody)

RRID:AB_777165

This recombinant monoclonal targets PDGF Receptor beta

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Mouse PDGF R alpha Antibody (antibody)

RRID:AB_2236897

This polyclonal targets Mouse PDGF R alpha

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Anti-NG2 Chondroitin Sulfate Proteoglycan (antibody)

RRID:AB_91789

This polyclonal targets NG2 Chondroitin Sulfate Proteoglycan

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Anti-NeuN (antibody)

RRID:AB_11205592

This polyclonal targets NeuN

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Anti-NeuN (antibody)

RRID:AB_2298772

This monoclonal targets NeuN

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Guinea pig Anti-VGLUT2, Unconjugated (antibody)

RRID:AB_1587626

This polyclonal targets VGLUT2

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Guinea pig Anti-Vesicular Glutamate Transporter 1 (VGLUT1) Polyclonal antibody, Unconjugated (antibody)

RRID:AB_2301751

This polyclonal targets VGLUT1

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Anti-Glutamate Receptor 2 & 3 (antibody)

RRID:AB_90710

This polyclonal targets Glutamate Receptor 2 & 3

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Anti-Green Fluorescent Protein Antibody (antibody)

RRID:AB_10000240

This polyclonal targets Green Fluorescent Protein (GFP)

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Goat Anti-GFP (Green Fluorescent Protein) Polyclonal Antibody, Fluorescein Conjugated (antibody)

RRID:AB_305635

This polyclonal targets GFP (FITC)

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Anti-GFAP (antibody)

RRID:AB_10641162

This polyclonal targets GFAP

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Anti-Glial Fibrillary Acidic Protein (antibody)

RRID:AB_177521

This polyclonal targets Glial Fibrillary Acidic Protein

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Mouse Anti-Glial Fibrillary Acidic Protein (GFAP) Monoclonal Antibody, Cy3 Conjugated, Clone G-A-5 (antibody)

RRID:AB_476889

This monoclonal targets Glial Fibrillary Acidic Protein (GFAP)

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Anti-Fibronectin antibody produced in rabbit (antibody)

RRID:AB_476976

This unknown targets Fibronectin

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ER81 (H-70) (antibody)

RRID:AB_2100826

This polyclonal targets ETV1

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CDP (M-222) (antibody)

RRID:AB_2261231

This polyclonal targets CUX1

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mu Crystallin antibody (antibody)

RRID:AB_943673

This monoclonal targets mu Crystallin antibody

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Anti-Type VI Collagen-UNLB (antibody)

RRID:AB_2721908

This polyclonal targets Type VI Collagen

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Anti-Type IV Collagen-UNLB (antibody)

RRID:AB_2721907

This polyclonal targets type IV collagen

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RABBIT ANTI MOUSE COLLAGEN IV (antibody)

RRID:AB_2082660

This polyclonal targets Col4a3

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Rabbit Anti-Collagen III Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_306066

This polyclonal targets Collagen III

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Collagen I antibody (antibody)

RRID:AB_446161

This polyclonal targets Collagen I

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Rabbit Anti-Human IGFBP-5 (123-145) (Insulin-like Growth Factor Binding Protein-5) Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_207951

This polyclonal targets Human IGFBP-5 (123-145) (Insulin-like Growth Factor Binding Protein-5)

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Rat Anti-Mouse CD68 Monoclonal antibody, Unconjugated, Clone FA-11 (antibody)

RRID:AB_324217

This monoclonal targets Mouse CD68

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CD31 (antibody)

RRID:AB_393571

This monoclonal targets CD31

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CaMKII-α (6G9) Mouse (antibody)

RRID:AB_2721906

This monoclonal targets CaMKII-α

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Anti-Serotonin, clone YC5/45 (antibody)

RRID:AB_11213564

This monoclonal targets Serotonin clone YC5/45

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5-HT (Serotonin) Goat Antibody (antibody)

RRID:AB_572262

This polyclonal targets Serotonin

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B6.129X1-Gt(ROSA)26Sor^tm1(EYFP)Cos/J (organism)

RRID:IMSR_JAX:006148

Mus musculus with name B6.129X1-Gt(ROSA)26Sor^tm1(EYFP)Cos/J from IMSR.

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HTSeq (software resource)

RRID:SCR_005514

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Software Python package that provides infrastructure to process data from high-throughput sequencing assays. While the main purpose of HTSeq is to allow you to write your own analysis scripts, customized to your needs, there are also a couple of stand-alone scripts for common tasks that can be used without any Python knowledge.

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Cufflinks (software resource)

RRID:SCR_014597

Software tool for transcriptome assembly and differential expression analysis for RNA-Seq. Includes script called cuffmerge that can be used to merge together several Cufflinks assemblies. It also handles running Cuffcompare as well as automatically filtering a number of transfrags that are likely to be artifacts. If the researcher has a reference GTF file, the researcher can provide it to the script to more effectively merge novel isoforms and maximize overall assembly quality.

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TopHat (software resource)

RRID:SCR_013035

Software tool for fast and high throughput alignment of shotgun cDNA sequencing reads generated by transcriptomics technologies. Fast splice junction mapper for RNA-Seq reads. Aligns RNA-Seq reads to mammalian-sized genomes using ultra high-throughput short read aligner Bowtie, and then analyzes mapping results to identify splice junctions between exons.TopHat2 is accurate alignment of transcriptomes in presence of insertions, deletions and gene fusions.

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Picard (software toolkit)

RRID:SCR_006525

Java toolset for working with next generation sequencing data in the BAM format.

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DAVID (software resource)

RRID:SCR_001881

Bioinformatics resource system including web server and web service for functional annotation and enrichment analyses of gene lists. Consists of comprehensive knowledgebase and set of functional analysis tools. Includes gene centered database integrating heterogeneous gene annotation resources to facilitate high throughput gene functional analysis.

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Fiji (software resource)

RRID:SCR_002285

Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.

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GraphPad Prism (software resource)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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Peroxidase-AffiniPure F(ab')2 Fragment Donkey Anti-Goat IgG (H+L) (min X Ck,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat Sr Prot) (antibody)

RRID:AB_2340392

This unknown targets Goat IgG (H+L)

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Peroxidase-AffiniPure F(ab')2 Fragment Donkey Anti-Rabbit IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340590

This unknown targets Rabbit IgG (H+L)

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Peroxidase-AffiniPure F(ab')2 Fragment Donkey Anti-Mouse IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340774

This unknown targets Mouse IgG (H+L)

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S100A4 antibody (antibody)

RRID:AB_2183775

This polyclonal targets S100A4 antibody

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Rabbit Anti-Periostin Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_2299859

This polyclonal targets Periostin

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PDGF Receptor beta (28E1) Rabbit mAb (antibody)

RRID:AB_2162497

This recombinant monoclonal targets PDGFRB

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PDIA2 polyclonal antibody (antibody)

RRID:AB_10556016

This polyclonal targets PDIA2 polyclonal antibody

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anti SERPINH1 / HSP47 (antibody)

RRID:AB_1954041

This unknown targets anti SERPINH1 / HSP47

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Goat Anti-GFP (Green Fluorescent Protein) Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_305643

This polyclonal targets GFP

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Anti-Glyceraldehyde-3-Phosphate Dehydrogenase Antibody, clone 6C5 (antibody)

RRID:AB_2107445

This monoclonal targets Glyceraldehyde-3-PDH (GAPDH)

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Alexa Fluor 647-AffiniPure F(ab')2 Fragment Donkey Anti-Guinea Pig IgG (H+L) (min X Bov,Ck,Gt,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340477

This unknown targets Guinea Pig IgG (H+L)

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Guinea Pig IgG (H+L) (min X Bov,Ck,Gt,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340461

This unknown targets Guinea Pig IgG (H+L)

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Alexa Fluor 488-AffiniPure F(ab')2 Fragment Donkey Anti-Guinea Pig IgG (H+L) (min X Bov,Ck,Gt,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340473

This unknown targets Guinea Pig IgG (H+L)

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DyLight 405-AffiniPure F(ab')2 Fragment Donkey Anti-Guinea Pig IgG (H+L) (min X Bov,Ck,Gt,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2632564

This unknown targets

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Alexa Fluor 488-AffiniPure F(ab')2 Fragment Donkey Anti-Rat IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Shp Sr Prot) (antibody)

RRID:AB_2340686

This unknown targets Rat IgG (H+L)

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Alexa Fluor 647-AffiniPure F(ab')2 Fragment Donkey Anti-Chicken IgY (IgG) (H+L) (min X Bov,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340380

This unknown targets Chicken IgY (IgG) (H+L)

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Chicken IgY (IgG) (H+L) (min X Bov,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340364

This unknown targets Chicken IgY (IgG) (H+L)

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Alexa Fluor 488-AffiniPure F(ab')2 Fragment Donkey Anti-Chicken IgY (IgG) (H+L) (min X Bov,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340376

This unknown targets Chicken IgY (IgG) (H+L)

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DyLight 405-AffiniPure F(ab')2 Fragment Donkey Anti-Chicken IgY (IgG) (H+L) (min X Bov,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2632562

This unknown targets

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Alexa Fluor 647-AffiniPure F(ab')2 Fragment Donkey Anti-Goat IgG (H+L) (min X Ck,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat Sr Prot) (antibody)

RRID:AB_2340438

This unknown targets Goat IgG (H+L)

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Goat IgG (H+L) (min X Ck,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat Sr Prot) (antibody)

RRID:AB_2340413

This unknown targets Goat IgG (H+L)

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Alexa Fluor 488-AffiniPure F(ab')2 Fragment Donkey Anti-Goat IgG (H+L) (min X Ck,GP,Sy Hms,Hrs,Hu,Ms,Rb,Rat Sr Prot) (antibody)

RRID:AB_2340430

This unknown targets Goat IgG (H+L)

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Alexa Fluor 647 AffiniPure F(ab')₂ Fragment Donkey Anti-Rabbit IgG (H+L) (antibody)

RRID:AB_2340625

This polyclonal targets IgG (H+L)

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Cy3-AffiniPure Donkey Anti-Rabbit IgG (H+L) (antibody)

RRID:AB_2313568

This polyclonal targets

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Alexa Fluor® 488 AffiniPure F(ab')₂ Fragment Donkey Anti-Rabbit IgG (H+L) (antibody)

RRID:AB_2340619

This polyclonal secondary targets IgG (H+L)

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DyLight 405-AffiniPure F(ab')2 Fragment Donkey Anti-Rabbit IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rat,Shp Sr Prot) (antibody)

RRID:AB_2632566

This unknown targets

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Alexa Fluor 647-AffiniPure F(ab')2 Fragment Donkey Anti-Mouse IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340866

This unknown targets Mouse IgG (H+L)

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Mouse IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340817

This unknown targets Mouse IgG (H+L)

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Alexa Fluor 488 donkey anti-mouse (antibody)

RRID:AB_2340850

This polyclonal targets

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Alexa Fluor 647-AffiniPure F(ab')2 Fragment Donkey Anti-Rat IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Shp Sr Prot) (antibody)

RRID:AB_2340696

This unknown targets Rat IgG (H+L)

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Alexa Fluor 594-AffiniPure F(ab')2 Fragment Donkey Anti-Rat IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Shp Sr Prot) (antibody)

RRID:AB_2340691

This unknown targets Rat IgG (H+L)

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Biotin-SP-AffiniPure F(ab')2 Fragment Donkey Anti-Rabbit IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340594

This unknown targets Rabbit IgG (H+L)

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Biotin-SP-AffiniPure F(ab')2 Fragment Donkey Anti-Mouse IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Rb,Rat,Shp Sr Prot) (antibody)

RRID:AB_2340788

This unknown targets Mouse IgG (H+L)

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NOT AN ANTIBODY Alexa Fluor 594-Streptavidin (antibody)

RRID:AB_2337250

This unknown targets Biotin

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Cy3-Streptavidin antibody (antibody)

RRID:AB_2337244

This polyclonal targets Cy3-Streptavidin

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PGP9.5 antibody - Neuronal Marker (antibody)

RRID:AB_297150

This polyclonal targets PGP9.5 - Neuronal Marker

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Rabbit Anti-PGP9.5 Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_297145

This polyclonal targets PGP9.5 - Neuronal Marker

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Synaptophysin antibody [SY38] (antibody)

RRID:AB_2198854

This monoclonal targets Syp

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Rabbit Anti-Synapsin I Polyclonal antibody, Unconjugated (antibody)

RRID:AB_90757

This polyclonal targets Synapsin I

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Anti-Synapsin 1 (antibody)

RRID:AB_2619772

This monoclonal targets Synapsin 1

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S100 (antibody)

RRID:AB_10013383

This polyclonal targets S100 isolated from cow brain.

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Mouse Podocalyxin Affinity Purified Polyclonal Ab (antibody)

RRID:AB_354858

This polyclonal targets Mouse Podocalyxin Affinity Purified Ab

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Recombinant Anti-PDGFR beta antibody [Y92] - C-terminal (antibody)

RRID:AB_777165

This recombinant monoclonal targets PDGF Receptor beta

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Mouse PDGF R alpha Antibody (antibody)

RRID:AB_2236897

This polyclonal targets Mouse PDGF R alpha

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Myelin Protein Zero antibody (antibody)

RRID:AB_2144668

This polyclonal targets Mpz

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Anti-NG2 Chondroitin Sulfate Proteoglycan (antibody)

RRID:AB_91789

This polyclonal targets NG2 Chondroitin Sulfate Proteoglycan

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Anti-NeuN (antibody)

RRID:AB_11205592

This polyclonal targets NeuN

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Anti-NeuN (antibody)

RRID:AB_2298772

This monoclonal targets NeuN

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Guinea pig Anti-VGLUT2, Unconjugated (antibody)

RRID:AB_1587626

This polyclonal targets VGLUT2

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Guinea pig Anti-Vesicular Glutamate Transporter 1 (VGLUT1) Polyclonal antibody, Unconjugated (antibody)

RRID:AB_2301751

This polyclonal targets VGLUT1

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Anti-Glutamate Receptor 2 & 3 (antibody)

RRID:AB_90710

This polyclonal targets Glutamate Receptor 2 & 3

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Anti-Green Fluorescent Protein Antibody (antibody)

RRID:AB_10000240

This polyclonal targets Green Fluorescent Protein (GFP)

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Goat Anti-GFP (Green Fluorescent Protein) Polyclonal Antibody, Fluorescein Conjugated (antibody)

RRID:AB_305635

This polyclonal targets GFP (FITC)

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Anti-GFAP (antibody)

RRID:AB_10641162

This polyclonal targets GFAP

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Anti-Glial Fibrillary Acidic Protein (antibody)

RRID:AB_177521

This polyclonal targets Glial Fibrillary Acidic Protein

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Mouse Anti-Glial Fibrillary Acidic Protein (GFAP) Monoclonal Antibody, Cy3 Conjugated, Clone G-A-5 (antibody)

RRID:AB_476889

This monoclonal targets Glial Fibrillary Acidic Protein (GFAP)

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Anti-Fibronectin antibody produced in rabbit (antibody)

RRID:AB_476976

This unknown targets Fibronectin

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ER81 (H-70) (antibody)

RRID:AB_2100826

This polyclonal targets ETV1

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CDP (M-222) (antibody)

RRID:AB_2261231

This polyclonal targets CUX1

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Ctip2 antibody [25B6] - ChIP Grade (antibody)

RRID:AB_2064130

This monoclonal targets Ctip2

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mu Crystallin antibody (antibody)

RRID:AB_943673

This monoclonal targets mu Crystallin antibody

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Rabbit Anti-Collagen VI Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_305585

This polyclonal targets Collagen VI

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Anti-Type VI Collagen-UNLB (antibody)

RRID:AB_2721908

This polyclonal targets Type VI Collagen

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Anti-Type IV Collagen-UNLB (antibody)

RRID:AB_2721907

This polyclonal targets type IV collagen

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RABBIT ANTI MOUSE COLLAGEN IV (antibody)

RRID:AB_2082660

This polyclonal targets Col4a3

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Rabbit Anti-Collagen III Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_306066

This polyclonal targets Collagen III

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Collagen I antibody (antibody)

RRID:AB_446161

This polyclonal targets Collagen I

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Rabbit Anti-Human IGFBP-5 (123-145) (Insulin-like Growth Factor Binding Protein-5) Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_207951

This polyclonal targets Human IGFBP-5 (123-145) (Insulin-like Growth Factor Binding Protein-5)

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Rat Anti-Mouse CD68 Monoclonal antibody, Unconjugated, Clone FA-11 (antibody)

RRID:AB_324217

This monoclonal targets Mouse CD68

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CD31 (antibody)

RRID:AB_393571

This monoclonal targets CD31

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CaMKII-α (6G9) Mouse (antibody)

RRID:AB_2721906

This monoclonal targets CaMKII-α

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Anti-Serotonin, clone YC5/45 (antibody)

RRID:AB_11213564

This monoclonal targets Serotonin clone YC5/45

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5-HT (Serotonin) Goat Antibody (antibody)

RRID:AB_572262

This polyclonal targets Serotonin

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Rat IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Shp Sr Prot) (antibody)

RRID:AB_2340669

This unknown targets Rat IgG (H+L)

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Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Rat IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Shp Sr Prot) (antibody)

RRID:AB_2340669

This unknown targets Rat IgG (H+L)

View all literature mentions

Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Rat IgG (H+L) (min X Bov,Ck,Gt,GP,Sy Hms,Hrs,Hu,Ms,Rb,Shp Sr Prot) (antibody)

RRID:AB_2340669

This unknown targets Rat IgG (H+L)

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B6.129X1-Gt(ROSA)26Sor^tm1(EYFP)Cos/J (organism)

RRID:IMSR_JAX:006148

Mus musculus with name B6.129X1-Gt(ROSA)26Sor^tm1(EYFP)Cos/J from IMSR.

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Rabbit Anti-Collagen VI Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_305585

This polyclonal targets Collagen VI

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Publication

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.

Research resources used in this publication

Additional research tools detected in this publication

Antibodies used in this publication

Associated grants

This is a list of tools and resources that we have found mentioned in this publication.

RRID:SCR_004633

RRID:SCR_008539

RRID:SCR_008117

RRID:SCR_013311

RRID:SCR_013612

RRID:SCR_005375

RRID:SCR_010279

RRID:SCR_013575

RRID:SCR_014199

RRID:IMSR_JAX:000664

RRID:AB_2340669

RRID:AB_305585

RRID:AB_305643

RRID:AB_10013383

RRID:AB_2144668

RRID:AB_2064130

RRID:AB_2340392

RRID:AB_2340590

RRID:AB_2340774

RRID:AB_2183775

RRID:AB_2299859

RRID:AB_2162497

RRID:AB_10556016

RRID:AB_1954041

RRID:AB_2107445

RRID:AB_2340477

RRID:AB_2340461

RRID:AB_2340473

RRID:AB_2632564

RRID:AB_2340686

RRID:AB_2340380

RRID:AB_2340364

RRID:AB_2340376

RRID:AB_2632562

RRID:AB_2340438

RRID:AB_2340413

RRID:AB_2340430

RRID:AB_2340625

RRID:AB_2313568

RRID:AB_2340619

RRID:AB_2632566

RRID:AB_2340866

RRID:AB_2340817

RRID:AB_2340850

RRID:AB_2340696

RRID:AB_2340691

RRID:AB_2340594

RRID:AB_2340788

RRID:AB_2337250

RRID:AB_2337244

RRID:AB_297150

RRID:AB_297145

RRID:AB_2198854

RRID:AB_90757

RRID:AB_2619772

RRID:AB_354858

RRID:AB_777165

RRID:AB_2236897

RRID:AB_91789

RRID:AB_11205592

RRID:AB_2298772

RRID:AB_1587626

RRID:AB_2301751

RRID:AB_90710

RRID:AB_10000240

RRID:AB_305635

RRID:AB_10641162

RRID:AB_177521

RRID:AB_476889