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Oligodendrocytes (OLs), the myelin-forming CNS glia, are highly vulnerable to cellular stresses, and a severe myelin loss underlies numerous CNS disorders. Expedited OL regeneration may prevent further axonal damage and facilitate functional CNS repair. Although adult OL progenitors (OPCs) are the primary players for OL regeneration, targetable OPC-specific intracellular signaling mechanisms for facilitated OL regeneration remain elusive. Here, we report that OPC-targeted PTEN inactivation in the mouse, in contrast to OL-specific manipulations, markedly promotes OL differentiation and regeneration in the mature CNS. Unexpectedly, an additional deletion of mTOR did not reverse the enhanced OL development from PTEN-deficient OPCs. Instead, ablation of GSK3β, another downstream signaling molecule that is negatively regulated by PTEN-Akt, enhanced OL development. Our results suggest that PTEN persistently suppresses OL development in an mTOR-independent manner, and at least in part, via controlling GSK3β activity. OPC-targeted PTEN-GSK3β inactivation may benefit facilitated OL regeneration and myelin repair.
Pubmed ID: 29461205 RIS Download
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An independent, nonprofit organization focused on mammalian genetics research to advance human health. Their mission is to discover the genetic basis for preventing, treating, and curing human disease, and to enable research for the global biomedical community. Jackson Laboratory breeds and manages colonies of mice as resources for other research institutions and laboratories, along with providing software and techniques. Jackson Lab also conducts genetic research and provides educational material for various educational levels.
View all literature mentionsCommercial instrument and chemical vendor. Developer and manufacturer of specialized technological products for life science research and clinical diagnostics markets.
View all literature mentionsA contract research organization providing drug development and animal testing services. Under the name Covance Research Products Inc., based in Denver, Pennsylvania, the company also deals in the import, breeding and sale of laboratory animals. It breeds dogs, rabbits, guinea pigs, non-human primates, and pigs, and runs the largest non-human primate laboratory in Germany. (Wikipedia)
View all literature mentionsDigital image processing system where microscope settings and processing steps may be adjusted in single user interface. Can acquire images from variety of cameras. Includes software package for capturing, archiving and preparing images for publication. Allows users to visualize and present images in several dimensions. Functionality of imaging toolbox expands constantly with wide range of different modules that are tailored to specific applications or microscope accessories. This resource is duplicated by SCR_018376
View all literature mentionsGene expression data and maps of mouse central nervous system. Gene expression atlas of developing adult central nervous system in mouse, using in situ hybridization and transgenic mouse techniques. Collection of pictorial gene expression maps of brain and spinal cord of mouse. Provides tools to catalog, map, and electrophysiologically record individual cells. Application of Cre recombinase technologies allows for cell-specific gene manipulation. Transgenic mice created by this project are available to scientific community.
View all literature mentionsPrivately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related reagents used to study cell signaling pathways that impact human health.
View all literature mentionsAn Organization portal, Antibody supplier, Service resource,
View all literature mentionsProteintech Europe Ltd is an ISO 9001:2008 certified company
View all literature mentionsA commercial antibody vendor, specializing in secondary antibodies.
View all literature mentionsNational public repository system for mutant mice. Archives and distributes scientifically valuable spontaneous and induced mutant mouse strains and ES cell lines for use by biomedical research community. Includes breeding/distribution facilities and information coordinating center. Mice strains are cryopreserved, unless live colony must be established. Live mice are supplied from production colony, from colony recovered from cryopreservation, or via micro-injection of cell line into host blastocysts. MMRRC member facilities also develop technologies to improve handling of mutant mice, including advances in assisted reproductive techniques, cryobiology, genetic analysis, phenotyping and infectious disease diagnostics.
View all literature mentionsCenter that imports, archives, maintains, and distributes mutant mouse alleles as live mice, frozen germplasm, stem cells, and molecular vectors for use in biomedical research. The MMRRC Davis receives transgenics, knockouts, and other kinds of mutant mouse lines at no cost to the donor, and after re-derivation and cryopreservation, distributes breeding stock, germplasm, cells, or tissues of genetically-defined and pathogen-free mice for a small fee to requesting investigators.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis monoclonal targets CD140a
View all literature mentionsThis polyclonal targets green fluorescent protein (YP_002302326)
View all literature mentionsThis monoclonal targets Akt (pan) (C67E7) Rabbit mAb
View all literature mentionsThis monoclonal targets Human CD28
View all literature mentionsThis monoclonal targets Myelin Basic Protein (SMI 99) Purified
View all literature mentionsThis monoclonal targets Phospho-GSK-3beta (Ser9)
View all literature mentionsThis monoclonal targets Chemical BrdU
View all literature mentionsThis polyclonal targets Oligodendrocute transcription factor 2
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis polyclonal targets CNP (2,3-cyclic nucleotide-3-phosphodiesterase)
View all literature mentionsThis polyclonal targets green fluorescent protein (YP_002302326)
View all literature mentionsThis monoclonal targets MAG (A-11)
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets Myelin Proteolipid Protein (PLP), C-terminus
View all literature mentionsThis polyclonal targets GFP tag
View all literature mentionsThis polyclonal targets Ki67 antibody - Proliferation Marker
View all literature mentionsThis monoclonal targets Mog
View all literature mentionsThis monoclonal targets APC
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis unknown targets Guinea Pig IgG (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets goat IgG
View all literature mentionsMus musculus with name B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J from IMSR.
View all literature mentionsMus musculus with name B6.129S4-Ptentm1Hwu/J from IMSR.
View all literature mentionsMus musculus with name STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato.-EGFP)Luo/J from IMSR.
View all literature mentionsMus musculus with name B6N.Cg-Tg(Pdgfra-cre/ERT)467Dbe/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(Mobp-EGFP)IN1Gsat/Mmucd from MMRRC.
View all literature mentionsMus musculus with name B6.129S4-Mtortm1.2Koz/J from IMSR.
View all literature mentionsMus musculus with name B6;129S4-Olig1tm1(cre)Rth/J from IMSR.
View all literature mentionsMus musculus with name B6.129(Cg)-Gsk3btm2Jrw/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tsc1tm1Djk/J from IMSR.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 12,2023. Matlab code for two-factor (location and year) analysis-of-variance model for the calculation of climate anomalies, in which the reference interval is specified as the full length of the dataset. This scheme avoids the affects of shorter (e.g. 1961-1990) reference intervals on the temporal evolution of the spatial standard deviation of climate anomalies. Data files provided.
View all literature mentionsImage analysis software that acquires, analyzes, and archives research data without altering raw findings. It integrates data and changes how pixels are mapped to the screen for clearer display, rather than altering the pixels of the image data itself.
View all literature mentionsA software program for the Applied Biosystems StepOne and StepOnePlus Real-Time PCR Systems. StepOne software allows the user to open and analyze experiments generated from either the StepOne or the StepOnePlus system. Users can set up experiments, send experiments to the instrument, control the instrument settings, and collect and analyze data.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsThis polyclonal targets Oligodendrocute transcription factor 2
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis monoclonal targets Akt (pan) (C67E7) Rabbit mAb
View all literature mentionsThis monoclonal targets Phospho-GSK-3beta (Ser9)
View all literature mentionsThis monoclonal targets Mog
View all literature mentionsThis monoclonal targets MAG (A-11)
View all literature mentionsThis polyclonal targets CNP (2,3-cyclic nucleotide-3-phosphodiesterase)
View all literature mentionsThis monoclonal targets Myelin Proteolipid Protein (PLP), C-terminus
View all literature mentionsThis monoclonal targets CD140a
View all literature mentionsThis monoclonal targets Myelin Basic Protein (SMI 99) Purified
View all literature mentionsThis monoclonal targets APC
View all literature mentionsThis polyclonal targets green fluorescent protein (YP_002302326)
View all literature mentionsMus musculus with name B6.129(Cg)-Gsk3btm2Jrw/J from IMSR.
View all literature mentionsMus musculus with name B6;129S4-Olig1tm1(cre)Rth/J from IMSR.
View all literature mentionsMus musculus with name STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato.-EGFP)Luo/J from IMSR.
View all literature mentionsMus musculus with name B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J from IMSR.
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets Human CD28
View all literature mentionsThis polyclonal targets Ki67 antibody - Proliferation Marker
View all literature mentionsThis polyclonal targets Oligodendrocute transcription factor 2
View all literature mentionsThis monoclonal targets Chemical BrdU
View all literature mentionsThis polyclonal targets GFP tag
View all literature mentionsThis polyclonal targets green fluorescent protein (YP_002302326)
View all literature mentionsMus musculus with name STOCK Tg(Mobp-EGFP)IN1Gsat/Mmucd from MMRRC.
View all literature mentionsMus musculus with name B6N.Cg-Tg(Pdgfra-cre/ERT)467Dbe/J from IMSR.
View all literature mentionsThis monoclonal targets Myelin Basic Protein (SMI 99) Purified
View all literature mentionsMus musculus with name B6.129S4-Mtortm1.2Koz/J from IMSR.
View all literature mentionsMus musculus with name B6.129S4-Ptentm1Hwu/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tsc1tm1Djk/J from IMSR.
View all literature mentionsThis polyclonal targets GFP tag
View all literature mentionsThis polyclonal targets green fluorescent protein (YP_002302326)
View all literature mentionsThis polyclonal targets green fluorescent protein (YP_002302326)
View all literature mentionsThis monoclonal targets Human CD28
View all literature mentionsMus musculus with name B6.129S4-Ptentm1Hwu/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tsc1tm1Djk/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(Mobp-EGFP)IN1Gsat/Mmucd from MMRRC.
View all literature mentionsMus musculus with name STOCK Gt(ROSA)26Sortm4(ACTB-tdTomato.-EGFP)Luo/J from IMSR.
View all literature mentionsMus musculus with name B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J from IMSR.
View all literature mentionsMus musculus with name B6;129S4-Olig1tm1(cre)Rth/J from IMSR.
View all literature mentionsMus musculus with name B6N.Cg-Tg(Pdgfra-cre/ERT)467Dbe/J from IMSR.
View all literature mentionsThis monoclonal targets Myelin Proteolipid Protein (PLP), C-terminus
View all literature mentionsThis monoclonal targets CD140a
View all literature mentionsThis polyclonal targets Oligodendrocute transcription factor 2
View all literature mentionsThis monoclonal targets Mog
View all literature mentionsThis polyclonal targets CNP (2,3-cyclic nucleotide-3-phosphodiesterase)
View all literature mentionsThis monoclonal targets APC
View all literature mentionsThis monoclonal targets Chemical BrdU
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis monoclonal targets Akt (pan) (C67E7) Rabbit mAb
View all literature mentionsMus musculus with name B6.129(Cg)-Gsk3btm2Jrw/J from IMSR.
View all literature mentionsMus musculus with name B6.129S4-Mtortm1.2Koz/J from IMSR.
View all literature mentionsThis monoclonal targets MAG (A-11)
View all literature mentionsThis polyclonal targets Ki67 antibody - Proliferation Marker
View all literature mentionsThis monoclonal targets Phospho-GSK-3beta (Ser9)
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