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Publication

CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.

Cell stem cell | 2018

A crucial player in immune regulation, FoxP3+ regulatory T cells (Tregs) are drawing attention for their heterogeneity and noncanonical functions. Here, we describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment. These Tregs highly expressed an HSC marker, CD150, and localized within the HSC niche in the bone marrow (BM). Specific reduction of BM Tregs achieved by conditional deletion of CXCR4 in Tregs increased HSC numbers in the BM. Adenosine generated via the CD39 cell surface ectoenzyme on niche Tregs protected HSCs from oxidative stress and maintained HSC quiescence. In transplantation settings, niche Tregs prevented allogeneic (allo-) HSC rejection through adenosine and facilitated allo-HSC engraftment. Furthermore, transfer of niche Tregs promoted allo-HSC engraftment to a much greater extent than transfer of other Tregs. These results identify a unique niche-associated Treg subset and adenosine as regulators of HSC quiescence, abundance, and engraftment, further highlighting their therapeutic utility.

Pubmed ID: 29456159 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

None found

Antibodies used in this publication

Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL132074
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL069438
  • Agency: NCI NIH HHS, United States
    Id: P30 CA013696
  • Agency: NIH HHS, United States
    Id: S10 OD020056
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL129506
  • Agency: NCRR NIH HHS, United States
    Id: S10 RR027050

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

InVivoPlus anti-mouse CD154 (CD40L) (antibody)

RRID:AB_1107601

This monoclonal targets CD40L (CD154)

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anti-mouse CD8α (antibody)

RRID:AB_1125541

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APC/Cyanine7 anti-mouse TCR beta chain (antibody)

RRID:AB_893624

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APC anti-mouse/human CD11b (antibody)

RRID:AB_312795

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Pacific Blue(TM) anti-mouse/human CD11b (antibody)

RRID:AB_755986

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PE/Cyanine7 anti-mouse Ly-6G/Ly-6C (Gr-1) (antibody)

RRID:AB_313381

This monoclonal targets Ly-6G Ly-6C

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Brilliant Violet 510(TM) anti-mouse CD45.2 (antibody)

RRID:AB_2650900

This monoclonal targets CD45.2

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PE anti-mouse CD45.1 (antibody)

RRID:AB_313497

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PE anti-mouse H-2Dd (antibody)

RRID:AB_313489

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APC anti-mouse H-2Kb (antibody)

RRID:AB_10564404

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Alexa Fluor(R) 647 anti-mouse CD144 (VE-cadherin) (antibody)

RRID:AB_10569114

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Alexa Fluor(R) 647 anti-mouse CD31 (antibody)

RRID:AB_2161029

This monoclonal targets CD31

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Brilliant Violet 605(TM) anti-mouse Ly-6A/E (Sca-1) (antibody)

RRID:AB_2650926

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APC anti-mouse CD304 (Neuropilin-1) (antibody)

RRID:AB_2562031

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PE/Cyanine7 anti-mouse CD150 (SLAM) (antibody)

RRID:AB_439797

This monoclonal targets CD150

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PE anti-mouse CD150 (SLAM) (antibody)

RRID:AB_313683

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Brilliant Violet 605(TM) anti-mouse CD73 (antibody)

RRID:AB_2561528

This monoclonal targets CD73

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APC anti-mouse CD73 (antibody)

RRID:AB_11218786

This monoclonal targets CD73

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PerCP/Cyanine5.5 anti-mouse CD73 (antibody)

RRID:AB_11219403

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Alexa Fluor(R) 700 anti-mouse/human CD44 (antibody)

RRID:AB_493713

This monoclonal targets CD44

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Pacific Blue(TM) anti-mouse/human CD44 (antibody)

RRID:AB_493683

This monoclonal targets CD44

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Brilliant Violet 785(TM) anti-mouse CD62L (antibody)

RRID:AB_2629685

This monoclonal targets CD62L

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APC anti-mouse CD62L (antibody)

RRID:AB_313099

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PerCP/Cyanine5.5 anti-mouse CD62L (antibody)

RRID:AB_2285839

This monoclonal targets CD62L

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Pacific Blue(TM) anti-mouse CD48 (antibody)

RRID:AB_756140

This monoclonal targets CD48

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Alexa Fluor(R) 700 anti-mouse CD48 (antibody)

RRID:AB_10612755

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Brilliant Violet 605(TM) anti-mouse CD4 (antibody)

RRID:AB_2564591

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PE/Cyanine7 anti-mouse CD4 (antibody)

RRID:AB_312707

This monoclonal targets CD4

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APC/Cyanine7 anti-mouse CD4 (antibody)

RRID:AB_312699

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APC anti-mouse CD4 (antibody)

RRID:AB_312697

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APC/Fire(TM) 750 anti-mouse CD3 (antibody)

RRID:AB_2572118

This monoclonal targets CD3

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Alexa Fluor(R) 700 anti-mouse CD3 (antibody)

RRID:AB_493697

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Brilliant Violet 510(TM) anti-mouse CD3 (antibody)

RRID:AB_2562555

This monoclonal targets CD3

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APC/Cyanine7 anti-mouse NK-1.1 (antibody)

RRID:AB_830871

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PerCP/Cyanine5.5 anti-mouse CD357 (GITR) (antibody)

RRID:AB_2563383

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HELIOS Monoclonal Antibody (22F6), PE, eBioscience™ (antibody)

RRID:AB_2572757

This monoclonal targets HELIOS

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FOXP3 Monoclonal Antibody (FJK-16s), APC, eBioscience (antibody)

RRID:AB_469457

This monoclonal targets FOXP3

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FOXP3 Monoclonal Antibody (FJK-16s), FITC, eBioscience (antibody)

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This monoclonal targets FOXP3

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CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), eFluor™ 450, eBioscience (antibody)

RRID:AB_1944394

This monoclonal targets CD357 (AITR/GITR)

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Ki-67 Monoclonal Antibody (SolA15), PE, eBioscience (antibody)

RRID:AB_11150954

This monoclonal targets Ki-67

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CD152 (CTLA-4) Monoclonal Antibody (UC10-4B9), PE, eBioscience (antibody)

RRID:AB_465879

This monoclonal targets CD152 (CTLA-4)

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CD200 Monoclonal Antibody (OX90), eFluor™ 660, eBioscience (antibody)

RRID:AB_11149877

This monoclonal targets CD200

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CD200 Monoclonal Antibody (OX90), PE, eBioscience (antibody)

RRID:AB_1907362

This monoclonal targets CD200

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KLRG1 Monoclonal Antibody (2F1), PE-eFluor™ 610, eBioscience (antibody)

RRID:AB_2574630

This monoclonal targets KLRG1

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CD279 (PD-1) Monoclonal Antibody (RMP1-30), eFluor™ 450, eBioscience (antibody)

RRID:AB_11150068

This monoclonal targets CD279 (PD-1)

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CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), APC, eBioscience (antibody)

RRID:AB_2688092

This monoclonal targets CD274 (PD-L1, B7-H1)

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CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), PE, eBioscience (antibody)

RRID:AB_466089

This monoclonal targets CD274 (PD-L1, B7-H1)

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CD39 Monoclonal Antibody (24DMS1), eFluor™ 660, eBioscience (antibody)

RRID:AB_11149300

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CD39 Monoclonal Antibody (24DMS1), PE-Cyanine7, eBioscience (antibody)

RRID:AB_1210766

This monoclonal targets CD39

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CD117 (c-Kit) Monoclonal Antibody (ACK2), APC-eFluor™ 780, eBioscience (antibody)

RRID:AB_1582226

This monoclonal targets CD117 (c-Kit)

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TER-119 Monoclonal Antibody (TER-119), FITC, eBioscience (antibody)

RRID:AB_465311

This monoclonal targets TER-119

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CD19 Monoclonal Antibody (eBio1D3 (1D3)), FITC, eBioscience (antibody)

RRID:AB_657666

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CD4 Monoclonal Antibody (GK1.5), FITC, eBioscience (antibody)

RRID:AB_464893

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CD8a Monoclonal Antibody (53-6.7), FITC, eBioscience (antibody)

RRID:AB_464916

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CD3e Monoclonal Antibody (145-2C11), FITC, eBioscience (antibody)

RRID:AB_464883

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CD2 Monoclonal Antibody (RM2-5), FITC, eBioscience (antibody)

RRID:AB_464874

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Ly-6G/Ly-6C Monoclonal Antibody (RB6-8C5), FITC, eBioscience (antibody)

RRID:AB_465315

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CD11b Monoclonal Antibody (M1/70), FITC, eBioscience (antibody)

RRID:AB_11042156

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CD45R (B220) Monoclonal Antibody (RA3-6B2), FITC, eBioscience (antibody)

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C;129S-Adora2atm1Jfc/J (organism)

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Mus musculus with name C;129S-Adora2atm1Jfc/J from IMSR.

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STOCK Cxcl12tm2.1Sjm/J (organism)

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Mus musculus with name STOCK Cxcl12tm2.1Sjm/J from IMSR.

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B6.129(Cg)-Leprtm2(cre)Rck/J (organism)

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Mus musculus with name B6.129(Cg)-Leprtm2(cre)Rck/J from IMSR.

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STOCK Cxcl12tm1.1Sjm/J (organism)

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B6.129P2-Cxcr4tm2Yzo/J (organism)

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Mus musculus with name B6.129P2-Cxcr4tm2Yzo/J from IMSR.

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B6.Cg-Foxp3tm2Tch/J (organism)

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B6.129(Cg)-Foxp3tm4(YFP/icre)Ayr/J (organism)

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Mus musculus with name B6.129(Cg)-Foxp3tm4(YFP/icre)Ayr/J from IMSR.

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B6.129S1-Nt5etm1Lft/J (organism)

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B6.Cg-Tg(CAG-DsRed*MST)1Nagy/J (organism)

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Mus musculus with name B6.Cg-Tg(CAG-DsRed*MST)1Nagy/J from IMSR.

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C57BL/6-Tg(UBC-GFP)30Scha/J (organism)

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Mus musculus with name C57BL/6-Tg(UBC-GFP)30Scha/J from IMSR.

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B10.A-H2a H2-T18/SgSnJ (organism)

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Mus musculus with name B10.A-H2a H2-T18/SgSnJ from IMSR.

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B6.SJL-Ptprca Pepc/BoyJ (organism)

RRID:IMSR_JAX:002014

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BALB/cJ (organism)

RRID:IMSR_JAX:000651

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C57BL/6J (organism)

RRID:IMSR_JAX:000664

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