It has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted to the brain in unmixed, feature-specific channels. To faithfully convey feature-specific information from retina to cortex, thalamic relay cells must receive inputs from only a small number of functionally similar retinal ganglion cells. However, recent studies challenged this by revealing substantial levels of retinal convergence onto relay cells. Here, we sought to identify mechanisms responsible for the assembly of such convergence. Using an unbiased transcriptomics approach and targeted mutant mice, we discovered a critical role for the synaptic adhesion molecule Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) in the emergence of retinothalamic convergence. Importantly, LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of retinothalamic convergence in vision.
Pubmed ID: 29424692 RIS Download
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View all literature mentionsMus musculus with name STOCK Tg(Crh-cre)KN282Gsat/Mmucd from MMRRC.
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View all literature mentionsThis polyclonal targets Human LRRTM1 Affinity Purified Ab
View all literature mentionsThis polyclonal targets VGLUT 2
View all literature mentionsThis polyclonal targets Iba1
View all literature mentionsThis monoclonal targets actin
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View all literature mentionsMus musculus with name B6;FVB-Nrn1tm1.2Ndiv/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(Aldh1l1-EGFP)OFC789Gsat/Mmucd from MMRRC.
View all literature mentionsMus musculus with name B6J.129-Atoh7tm1Gla/Mmucd from MMRRC.
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View all literature mentionsMus musculus with name STOCK Tg(Crh-cre)KN282Gsat/Mmucd from MMRRC.
View all literature mentionsThis polyclonal targets mouse mGluR1a, 945-1127 aa (NM_016976)
View all literature mentionsThis polyclonal targets mouse mGluR1a, 945-1127 aa (NM_016976)
View all literature mentions