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Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3+ regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4+ T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction. Specifically, Ragulator-interacting protein C17orf59, which limits mTORC1 activity, was upregulated in CD4+ T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction. By loss- and gain-of-function studies, including Treg depletion and transfers in vivo, we demonstrated that a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 stimulation with Foxp3+ Treg induction and adipose tissue function. Our findings offer a new mechanistic model in which tissue-specific Tregs maintain adipose tissue function.
Pubmed ID: 28877454 RIS Download
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Software package for differential gene expression analysis based on the negative binomial distribution. Used for analyzing RNA-seq data for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates.
View all literature mentionsCenter that produces knockout mice and carries out high-throughput phenotyping of each line in order to determine function of every gene in mouse genome. These mice will be preserved in repositories and made available to scientific community representing valuable resource for basic scientific research as well as generating new models for human diseases.
View all literature mentionsThis monoclonal targets Mouse CD14
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets IL-2
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal targets CD90/CD90.1
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets CD107b
View all literature mentionsThis monoclonal targets CD90.2
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD25 (IL-2Rα)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets CD16 / CD32
View all literature mentionsThis monoclonal targets CD62L (L-Selectin)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets mTOR
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Stat6, phospho (Tyr641)
View all literature mentionsThis monoclonal targets CD28
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal targets Phospho-Stat6 (Tyr641)
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsMus musculus with name C57BL/6-Tg(Foxp3-HBEGF/EGFP)23.2Spar/Mmjax from MMRRC.
View all literature mentionsMus musculus with name BALB/cByJ from IMSR.
View all literature mentionsMus musculus with name CBy.PL(B6)-Thy1a/ScrJ from IMSR.
View all literature mentionsMus musculus with name C.129S2-Stat6tm1Gru/J from IMSR.
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsScript distributed with the HT-Seq Python framework for processing RNA-seq or DNA-seq data.
View all literature mentionsQuality control software that perform checks on raw sequence data coming from high throughput sequencing pipelines. This software also provides a modular set of analyses which can give a quick impression of the quality of the data prior to further analysis.
View all literature mentionsOriginal SAMTOOLS package has been split into three separate repositories including Samtools, BCFtools and HTSlib. Samtools for manipulating next generation sequencing data used for reading, writing, editing, indexing,viewing nucleotide alignments in SAM,BAM,CRAM format. BCFtools used for reading, writing BCF2,VCF, gVCF files and calling, filtering, summarising SNP and short indel sequence variants. HTSlib used for reading, writing high throughput sequencing data.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 30,2023. Software for differential gene expression analysis based on the negative binomial distribution. It estimates variance-mean dependence in count data from high-throughput sequencing assays and tests for differential expression.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsA collection of tools for flow cytometer and application setup, data acquisition, and data analysis that help streamline flow cytometry workflows. It provides features to help users integrate flow systems into new application areas, including index sorting for stem cell and single-cell applications, as well as automation protocols for high-throughput and robotic laboratories.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsMus musculus with name C57BL/6-Tg(Foxp3-HBEGF/EGFP)23.2Spar/Mmjax from MMRRC.
View all literature mentionsgene symbol note: BLOC-1 related complex subunit 6; mutant strain: targeted mutation 1.1, Velocigene This is a legacy resource.
View all literature mentionsMus musculus with name C.129S2-Stat6tm1Gru/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Foxp3tm2Tch/J from IMSR.
View all literature mentionsMus musculus with name C.Cg-Foxp3tm2Tch/J from IMSR.
View all literature mentionsMus musculus with name BALB/cByJ from IMSR.
View all literature mentionsMus musculus with name CBy.PL(B6)-Thy1a/ScrJ from IMSR.
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets mTOR
View all literature mentionsThis monoclonal targets CD107b
View all literature mentionsThis monoclonal targets IL-2
View all literature mentionsThis polyclonal targets Phospho-Stat6 (Tyr641)
View all literature mentionsThis monoclonal targets Stat6, phospho (Tyr641)
View all literature mentionsThis monoclonal targets CD28
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD16 / CD32
View all literature mentionsThis monoclonal targets CD25 (IL-2Rα)
View all literature mentionsThis monoclonal targets CD90.2
View all literature mentionsThis monoclonal targets CD90/CD90.1
View all literature mentionsThis monoclonal targets Mouse CD14
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis monoclonal targets CD62L (L-Selectin)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsMus musculus with name B6.Cg-Foxp3tm2Tch/J from IMSR.
View all literature mentionsMus musculus with name C.Cg-Foxp3tm2Tch/J from IMSR.
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsMus musculus with name B6.Cg-Foxp3tm2Tch/J from IMSR.
View all literature mentionsMus musculus with name C.129S2-Stat6tm1Gru/J from IMSR.
View all literature mentionsMus musculus with name C.Cg-Foxp3tm2Tch/J from IMSR.
View all literature mentionsMus musculus with name CBy.PL(B6)-Thy1a/ScrJ from IMSR.
View all literature mentionsMus musculus with name BALB/cByJ from IMSR.
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsMus musculus with name C57BL/6-Tg(Foxp3-HBEGF/EGFP)23.2Spar/Mmjax from MMRRC.
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD62L (L-Selectin)
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets Mouse CD14
View all literature mentionsThis monoclonal targets CD90/CD90.1
View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis monoclonal targets CD90.2
View all literature mentionsThis monoclonal targets CD28
View all literature mentionsThis monoclonal targets Stat6, phospho (Tyr641)
View all literature mentionsThis monoclonal targets CD25 (IL-2Rα)
View all literature mentionsThis monoclonal targets CD16 / CD32
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets mTOR
View all literature mentionsThis monoclonal targets CD107b
View all literature mentionsThis monoclonal targets IL-2
View all literature mentionsThis polyclonal targets Phospho-Stat6 (Tyr641)
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