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Vascular endothelial growth factor (VEGF) is a major driver of blood vessel formation. However, the signal transduction pathways culminating in the biological consequences of VEGF signaling are only partially understood. Here, we show that the Hippo pathway effectors YAP and TAZ work as crucial signal transducers to mediate VEGF-VEGFR2 signaling during angiogenesis. We demonstrate that YAP/TAZ are essential for vascular development as endothelium-specific deletion of YAP/TAZ leads to impaired vascularization and embryonic lethality. Mechanistically, we show that VEGF activates YAP/TAZ via its effects on actin cytoskeleton and that activated YAP/TAZ induce a transcriptional program to further control cytoskeleton dynamics and thus establish a feedforward loop that ensures a proper angiogenic response. Lack of YAP/TAZ also results in altered cellular distribution of VEGFR2 due to trafficking defects from the Golgi apparatus to the plasma membrane. Altogether, our study identifies YAP/TAZ as central mediators of VEGF signaling and therefore as important regulators of angiogenesis.
Pubmed ID: 28867486 RIS Download
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Ultrafast and memory efficient tool for aligning sequencing reads to long reference sequences. Supports gapped, local, and paired end alignment modes. More suited to finding longer, gapped alignments in comparison with original Bowtie method.
View all literature mentionsSoftware ultrafast memory efficient tool for aligning sequencing reads. Bowtie is short read aligner.
View all literature mentionsThis monoclonal targets Phospho-VEGF Receptor 2 (Tyr1175)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
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View all literature mentionsThis monoclonal targets TGN38
View all literature mentionsThis polyclonal targets Phospho-Histone H3 (Ser10)
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis polyclonal targets Mouse/Rat Tie-2 Affinity Purified Ab
View all literature mentionsThis polyclonal targets Human TGN46
View all literature mentionsThis monoclonal targets VEGFR-2
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal secondary targets Rat IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets NRP1
View all literature mentionsThis unknown targets Phospho-p38 MAPK (Thr180, Tyr182)
View all literature mentionsThis monoclonal targets p38 MAPK (L53F8) Mouse mAb
View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb
View all literature mentionsThis polyclonal targets p44/42 MAPK (Erk1/2)
View all literature mentionsThis monoclonal targets Phospho-Akt (Ser473)
View all literature mentionsThis monoclonal targets Phospho-LATS1 (Thr1079) (D57D3) Rabbit mAb
View all literature mentionsThis polyclonal targets Phospho-LATS1 (Ser909)
View all literature mentionsThis monoclonal targets LATS1
View all literature mentionsThis monoclonal targets synthetic peptide corresponding to residues near the carboxy terminus of human Src.
View all literature mentionsThis polyclonal targets Src, phospho (Tyr418)
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View all literature mentionsThis polyclonal targets beta Tubulin (H-235)
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets VEGF Receptor 2 (55B11) Rabbit mAb
View all literature mentionsThis monoclonal targets Phospho-VEGF Receptor 2 (Tyr1059)
View all literature mentionsThis monoclonal targets VEGF Receptor 2, phospho (Tyr1212)
View all literature mentionsThis monoclonal targets VEGF Receptor 2, phospho (Tyr951)
View all literature mentionsThis polyclonal targets p-TAZ (Ser 89)
View all literature mentionsThis polyclonal targets YAP1
View all literature mentionsThis monoclonal targets TGN38 (B-6)
View all literature mentionsThis monoclonal targets Mouse Endoglin / CD105
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets Mouse TER-119 Erythroid Antigen MAb (Clone TER-119)
View all literature mentionsThis monoclonal targets Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp362 of human TAZ protein
View all literature mentionsThis monoclonal targets Phospho-VEGF Receptor 2 (Tyr1175)
View all literature mentionsCell line NIH 3T3 is a Spontaneously immortalized cell line with a species of origin Mus musculus
View all literature mentionsCell line CT26.WT is a Cancer cell line with a species of origin Mus musculus
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
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View all literature mentionsSoftware platform for complex network analysis and visualization. Used for visualization of molecular interaction networks and biological pathways and integrating these networks with annotations, gene expression profiles and other state data.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
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